CXCL7

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Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PDB rendering based on 1f9p.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 PPBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
扩展标识 遗传学121010 鼠基因1888712 同源基因48122 GeneCards: PPBP Gene
RNA表达模式
PBB GE PPBP 214146 s at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 5473 57349
Ensembl ENSG00000163736 ENSMUSG00000029372
UniProt P02775 Q9EQI5
mRNA序列 NM_002704 NM_023785
蛋白序列 NP_002695 NP_076274
基因位置 Chr 4:
74.85 – 74.85 Mb
Chr 5:
90.77 – 90.77 Mb
PubMed查询 [1] [2]

趋化因子CXCL7英语:Chemokine (C-X-C motif) ligand 7,CXCL7)是一个人类基因[1]。其编码的蛋白质为趋化因子(C-X-C基序)配体7 Chemokine (C-X-C motif) ligand,是一种CXC趋化因子细胞因子,其蛋白异型体为β-血小板球蛋白或原血小板碱性蛋白(英语:Pro-Platelet basic protein,PPBP)[2]

这种蛋白在血小板活化时被大量释放[3] ,能刺激多种过程,包括有丝分裂细胞外基质的合成、糖代谢英语glucose metabolism纤溶酶原激活物的合成[4][5]

参考文献[编辑]

  1. ^ Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7). 
  2. ^ Hristov M, Zernecke A, Bidzhekov K; 等. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ. Res. March 2007, 100 (4): 590–7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68. 
  3. ^ Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem. 1991, 266 (9): 5785–9. PMID 1826003. 
  4. ^ Castor C, Miller J, Walz D. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA. 1983, 80 (3): 765–9. PMC 393460. PMID 6572368. doi:10.1073/pnas.80.3.765. 
  5. ^ Castor C, Furlong A, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029. 

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