CXCL9

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Chemokine (C-X-C motif) ligand 9
标识
代号 CXCL9; CMK; Humig; MIG; SCYB9; crg-10
扩展标识 遗传学601704 鼠基因1352449 同源基因1813 GeneCards: CXCL9 Gene
RNA表达模式
PBB GE CXCL9 203915 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 4283 17329
Ensembl ENSG00000138755 ENSMUSG00000029417
UniProt Q07325 P18340
mRNA序列 NM_002416 NM_008599
蛋白序列 NP_002407 NP_032625
基因位置 Chr 4:
76.92 – 76.93 Mb
Chr 5:
92.32 – 92.33 Mb
PubMed查询 [1] [2]

CXCL9英语:Chemokine (C-X-C motif) ligand 9)是一小分子的细胞因子属于CXC趋化因子家族,又被称作“干扰素伽玛诱导的单核细胞因子”(Monokine induced by gamma interferon, MIG)[1] 。CXCL9是T细胞趋化因子[1]干扰素伽玛诱导CXCL9的表达。人类的CXCL9与CXCL10CXCL11的基因相邻聚集在第四染色体上[2] 。CXCL9,CXCL10, CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[3][4]

参见[编辑]

参考文献[编辑]

  1. ^ 1.0 1.1 Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.
  2. ^ Lee HH, Farber JM. Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster". Cytogenet Cell Genet. 1996;74(4):255-8.
  3. ^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  4. ^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

外部链接[编辑]