味覺感受器，類型2，成員50，TAS2R50 是一個人類基因組中TAS2R50 基因編碼的蛋白質，是苦味味覺感受器的一員。[1] [2] [3] [4]
參考文獻 [ 編輯 ]
^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855 doi:10.1038/ng1014 ^ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet Genome Res. Feb 2003, 98 (1): 45–53. PMID 12584440 doi:10.1159/000068546 ^ Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of Four Gene Variants Associated with Myocardial Infarction . Am J Hum Genet. Sep 2005, 77 (4): 596–605. PMC 1275608 PMID 16175505 doi:10.1086/491674 ^ Entrez Gene: TAS2R50 taste receptor, type 2, member 50 .
進一步閱讀 [ 編輯 ]
Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554 doi:10.1074/jbc.R100054200 Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982 doi:10.1016/S0959-4388(02)00345-8 Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 PMID 12477932 doi:10.1073/pnas.242603899 Zhang Y; Hoon MA; Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell. 2003, 112 (3): 293–301. PMID 12581520 doi:10.1016/S0092-8674(03)00071-0 Gerhard DS; Wagner L; Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 PMID 15489334 doi:10.1101/gr.2596504 Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes . Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549 doi:10.1093/molbev/msi027 Go Y, Satta Y, Takenaka O, Takahata N. Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates . Genetics. 2006, 170 (1): 313–26. PMC 1449719 PMID 15744053 doi:10.1534/genetics.104.037523
. PMID 16175505. doi:10.1086/491674.
