促甲状腺激素受体

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Thyroid stimulating hormone receptor
促甲状腺激素受体
Rendering based on PDB 1XUM.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 TSHR; CHNG1; LGR3; hTSHR-I
扩展标识 遗传学603372 鼠基因98849 同源基因315 IUPHAR:  TSH ChEMBL英语ChEMBL: 1963 GeneCards英语GeneCards: TSHR Gene
RNA表达模式
PBB GE TSHR 210055 at tn.png
PBB GE TSHR 215442 s at tn.png
PBB GE TSHR 215443 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez英语Entrez 7253 22095
Ensembl ENSG00000165409 ENSMUSG00000020963
UniProt P16473 P47750
mRNA序列 NM_000369 NM_001113404
蛋白序列 NP_000360 NP_001106875
基因位置 Chr 14:
81.42 – 81.61 Mb
Chr 12:
91.4 – 91.54 Mb
PubMed查询 [1] [2]

促甲状腺激素受体英语:thyrotropin receptorTSH receptorTSHR)是一种接受促甲状腺激素(thyrotropin)信号,刺激细胞生成甲状腺激素(T4)和三碘甲状腺激素(T3)的跨膜受体。TSHR是膜内在蛋白英语Integral membrane proteinG蛋白偶联受体超家族的一员[1],与Gs蛋白英语Gs alpha subunit相连接[2]

该受体主要出现在甲状腺上皮细胞英语thyroid epithelial cell的表面。

功能[编辑]

Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.

另见[编辑]

参考文献[编辑]

  1. ^ Farid NR, Szkudlinski MW. Minireview: structural and functional evolution of the thyrotropin receptor. Endocrinology. 2004, 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707. 
  2. ^ Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. J. Mol. Endocrinol. July 2010, 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719. 

延伸阅读[编辑]

  • Führer D, Wonerow P, Willgerodt H, Paschke R. Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.. J. Clin. Endocrinol. Metab. 1998, 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746. 
  • Farid NR, Kascur V, Balazs C. The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.. Eur. J. Endocrinol. 2000, 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027. 
  • Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.. Physiol. Rev. 2002, 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095. 
  • Tonacchera M, Vitti P, De Servi M; 等. Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.. J. Endocrinol. Invest. 2004, 26 (2 Suppl): 2–6. PMID 12762632. 
  • Arturi F, Scarpelli D, Coco A; 等. Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.. Thyroid. 2004, 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102. 
  • Vaidya B, Campbell V, Tripp JH; 等. Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.. Clin. Endocrinol. (Oxf). 2004, 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335. 
  • Takeshita A, Nagayama Y, Fujiyama K; 等. Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.. Biochem. Biophys. Res. Commun. 1992, 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355. 
  • Graves PN, Tomer Y, Davies TF. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.. Biochem. Biophys. Res. Commun. 1992, 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609. 
  • Loosfelt H, Pichon C, Jolivet A; 等. Two-subunit structure of the human thyrotropin receptor. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295. 
  • Nagayama Y, Russo D, Wadsworth HL; 等. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314. 
  • Murakami M, Mori M. Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease. Biochem. Biophys. Res. Commun. 1990, 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467. 
  • Heldin NE, Gustavsson B, Westermark K, Westermark B. A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. J. Clin. Endocrinol. Metab. 1992, 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520. 
  • Libert F, Passage E, Lefort A; 等. Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization. Cytogenet. Cell Genet. 1991, 54 (1–2): 82–3. doi:10.1159/000132964. PMID 2249482. 
  • Frazier AL, Robbins LS, Stork PJ; 等. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030. 
  • Misrahi M, Loosfelt H, Atger M; 等. Cloning, sequencing and expression of human TSH receptor. Biochem. Biophys. Res. Commun. 1990, 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212. 
  • Nagayama Y, Kaufman KD, Seto P, Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651. 
  • Libert F, Lefort A, Gerard C; 等. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690. 
  • Cuddihy RM, Bryant WP, Bahn RS. Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor. Thyroid. 1996, 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864. 
  • Bahn RS, Dutton CM, Heufelder AE, Sarkar G. A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy. J. Clin. Endocrinol. Metab. 1994, 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946. 
  • Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S. Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. N. Engl. J. Med. 1995, 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344. 

外部链接[编辑]