载脂蛋白B

载脂蛋白B
识别号
别名	APOB；, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B, FCHL2
外部ID	OMIM：107730 MGI：88052 HomoloGene：328 GeneCards：APOB
相关疾病
	代谢疾病、心血管疾病、血脂异常、familial hypobetalipoproteinemia 1、hypercholesterolemia, autosomal dominant, type b、家族性高胆固醇血症、hypobetalipoproteinemia
基因位置（人类）
染色体	2号染色体
终止	21,044,073 bp
基因位置（小鼠）
染色体	小鼠12号染色体
终止	8,066,835 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 血浆蛋白结合; • lipid binding; • lipid transporter activity; • cholesterol transfer activity; • lipase binding; • low-density lipoprotein particle receptor binding; • phospholipid binding; • heparin binding; • signaling receptor binding;
细胞组分	• 早期内吞体; • chylomicron remnant; • vesicle lumen; • 内质网; • endosome membrane; • mature chylomicron; • endoplasmic reticulum lumen; • vesicle membrane; • endosome lumen; • intermediate-density lipoprotein particle; • clathrin-coated endocytic vesicle membrane; • endoplasmic reticulum membrane; • 外排体; • endocytic vesicle lumen; • soma; • 细胞质; • 乳糜微粒; • very-low-density lipoprotein particle; • low-density lipoprotein particle; • endoplasmic reticulum exit site; • 细胞外空间; • smooth endoplasmic reticulum; • 细胞质基质; • 细胞膜; • lysosomal lumen; • 细胞内膜结合细胞器; • 细胞外区域; • high-density lipoprotein particle;
生物学过程	• artery morphogenesis; • in utero embryonic development; • 受精; • 受体介导的内吞作用; • positive regulation of cholesterol storage; • 脂质代谢; • cholesterol metabolic process; • cholesterol transport; • regulation of cholesterol biosynthetic process; • lipid transport; • 神经系统的发育; • leukocyte migration; • response to carbohydrate; • retinoid metabolic process; • steroid metabolic process; • triglyceride mobilization; • lipid catabolic process; • response to lipopolysaccharide; • positive regulation of macrophage derived foam cell differentiation; • cellular response to prostaglandin stimulus; • response to virus; • positive regulation of lipid storage; • cellular response to tumor necrosis factor; • response to selenium ion; • flagellated sperm motility; • positive regulation of gene expression; • response to organic substance; • cholesterol homeostasis; • 精子发生; • triglyceride catabolic process; • cholesterol efflux; • post-embryonic development; • lipoprotein transport; • toll-like receptor signaling pathway; • response to estradiol; • membrane organization; • chylomicron remodeling; • low-density lipoprotein particle remodeling; • chylomicron assembly; • very-low-density lipoprotein particle assembly; • chylomicron remnant clearance; • low-density lipoprotein particle clearance; • very-low-density lipoprotein particle clearance; • lipoprotein metabolic process; • lipoprotein biosynthetic process; • lipoprotein catabolic process; • 翻译后修饰; • transport;
	Sources:Amigo / QuickGO
直系同源
	338
	238055
	ENSG00000084674
	ENSMUSG00000020609
	P04114
	E9Q414
	NM_000384
	NM_009693
	NP_000375
	NP_033823
	维基数据
查看/编辑人类	查看/编辑小鼠

载脂蛋白B（英语：Apolipoprotein B，缩写ApoB，也称为脂蛋白B100 英语：Apolipoprotein B100）是乳糜微粒、极低密度脂蛋白、中密度脂蛋白（英语：intermediate-density lipoprotein）、低密度脂蛋白上的主要载脂蛋白^[6]^[7]，其由人类APOB基因编码。

参考文献

^ 與载脂蛋白B相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000084674 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020609 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR. Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. Journal of Clinical Lipidology. 2011, 5 (4): 264–272. PMID 21784371. doi:10.1016/j.jacl.2011.05.004.
^ Jacobson TA. Opening a new lipid "apo-thecary": incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular risk. Mayo Clinic Proceedings. 2011, 86 (8): 762–780. PMC 3146376 . PMID 21803958. doi:10.4065/mcp.2011.0128.

外部链接

Database of RNA editing (DARNED) （页面存档备份，存于互联网档案馆）.
Applied Research on Apolipoprotein-B （页面存档备份，存于互联网档案馆）
Human APOB genome location and APOB gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 與载脂蛋白B相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000084674 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020609 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR. Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. Journal of Clinical Lipidology. 2011, 5 (4): 264–272. PMID 21784371. doi:10.1016/j.jacl.2011.05.004.

[7] Jacobson TA. Opening a new lipid "apo-thecary": incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular risk. Mayo Clinic Proceedings. 2011, 86 (8): 762–780. PMC 3146376 . PMID 21803958. doi:10.4065/mcp.2011.0128.

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