莫克雌醇

莫克雌醇
臨床資料
商品名（英語：Drug nomenclature）	Surestryl
其他名稱	R-2858, RU-2858, NSC-118191; 11β-Methoxy-17α-ethynylestradiol; 11β-MeO-EE 11β-Methoxy-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol
懷孕分級	X (Contraindicated);
給藥途徑	口服
藥物類別（英語：Drug class）	Estrogen; Estrogen ether
ATC碼	G03CB04 (WHO) ;
法律規範狀態
法律規範	處方藥（℞-only）;
藥物動力學數據
生物利用度	33%
血漿蛋白結合率	Minimal
藥物代謝	Liver
生物半衰期	8.2 hours
識別資訊
	IUPAC命名法 (8S,9S,11S,13S,14S,17R)-17-ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol; ;
CAS號	34816-55-2
PubChem CID	11954041;
ChemSpider	10128336;
UNII	6923NT44OW;
KEGG	C14757;
ChEBI	CHEBI:34857;
ChEMBL	ChEMBL1628161;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID8022375 ;
化學資訊
化學式	C21H26O3
摩爾質量	326.44 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CC12CC(C3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O)OC;
	InChI InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1; Key:MTMZZIPTQITGCY-OLGWUGKESA-N;

莫克雌醇（英語：Moxestrol）是一種雌激素類藥物，商品名Surestryl，化學名為11β-甲氧基乙炔雌二醇，與RU-16117是11β-差向異構體，用於治療更年期綜合症和月經失調，在歐洲有上市銷售^[3]^[4]^[2]^[5]^[6]。

參考資料

^ ^1.0 ^1.1 ^1.2 Salmon, J.; Coussediere, D.; Cousty, C.; Raynaud, J.P. Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry. 1983, 19 (2): 1223–1234. ISSN 0022-4731. PMID 6887930. doi:10.1016/0022-4731(83)90421-1.
^ ^2.0 ^2.1 Jonathan J. Li; Satyabrata Nandi; Sara A. Li. Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer Science & Business Media. 6 December 2012: 184– [2021-11-30]. ISBN 978-1-4613-9208-8. （原始內容存檔於2021-11-30）.
^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 841– [2021-11-30]. ISBN 978-1-4757-2085-3. （原始內容存檔於2021-11-30）.
^ Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 186– [2021-11-30]. ISBN 978-0-7514-0499-9. （原始內容存檔於2021-11-30）.
^ Adrain D. Nunn. Radiopharmaceuticals: Chemistry and Pharmacology. CRC Press. 19 June 1992: 342– [2021-11-30]. ISBN 978-0-8247-8624-3. （原始內容存檔於2021-11-30）.
^ William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. The Extra Pharmacopoeia. Pharmaceutical Press. 1993: 1188 [2021-11-30]. ISBN 978-0-85369-300-0. （原始內容存檔於2021-11-30）. Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 µg weekly for long-term therapy to 25 to 250 µg daily for short-term use.

[SalmonCoussediere1983-1] 1.0 ^1.1 ^1.2 Salmon, J.; Coussediere, D.; Cousty, C.; Raynaud, J.P. Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry. 1983, 19 (2): 1223–1234. ISSN 0022-4731. PMID 6887930. doi:10.1016/0022-4731(83)90421-1.

[LiNandi2012-2] 2.0 ^2.1 Jonathan J. Li; Satyabrata Nandi; Sara A. Li. Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer Science & Business Media. 6 December 2012: 184– [2021-11-30]. ISBN 978-1-4613-9208-8. （原始內容存檔於2021-11-30）.

[Elks2014-3] J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 841– [2021-11-30]. ISBN 978-1-4757-2085-3. （原始內容存檔於2021-11-30）.

[MortonHall1999-4] Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 186– [2021-11-30]. ISBN 978-0-7514-0499-9. （原始內容存檔於2021-11-30）.

[Nunn1992-5] Adrain D. Nunn. Radiopharmaceuticals: Chemistry and Pharmacology. CRC Press. 19 June 1992: 342– [2021-11-30]. ISBN 978-0-8247-8624-3. （原始內容存檔於2021-11-30）.

[MartindaleSciences1993-6] William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. The Extra Pharmacopoeia. Pharmaceutical Press. 1993: 1188 [2021-11-30]. ISBN 978-0-85369-300-0. （原始內容存檔於2021-11-30）. Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 µg weekly for long-term therapy to 25 to 250 µg daily for short-term use.

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