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In 1966, the U.S. Army released the harmless ''[[Bacillus globigii]]'' into the tunnels of the [[New York subway system]] as part of a field study called ''A Study of the Vulnerability of Subway Passengers in New York City to Covert Attack with Biological Agents''.<ref name="rogue-state-150-151" /><ref>Moreno, 2001: [http://books.google.com/books?id=ZhMiN64D96cC&pg=PA234 p. 234]</ref><ref>Cina & Perper, 2010: [http://books.google.com/books?id=eHhtsODHWf0C&pg=PA95 p. 95]</ref><ref>{{Cite book|authors=Wheelis, Mark;Rózsa, Lajos; Dando, Malcolm|title=Deadly cultures: biological weapons since 1945|publisher=Harvard University Press|year=2006|isbn=9780674016996|pages=27–28|url=http://books.google.com/books?id=Usskez9NfEYC&pg=PA27}}</ref><ref>[http://www.democracynow.org/2005/7/13/how_the_u_s_government_exposed How the U.S. Government Exposed Thousands of Americans to Lethal Bacteria to Test Biological Warfare]</ref> The Chicago subway system was also subject to a similar experiment by the Army.<ref name="rogue-state-150-151" />
In 1966, the U.S. Army released the harmless ''[[Bacillus globigii]]'' into the tunnels of the [[New York subway system]] as part of a field study called ''A Study of the Vulnerability of Subway Passengers in New York City to Covert Attack with Biological Agents''.<ref name="rogue-state-150-151" /><ref>Moreno, 2001: [http://books.google.com/books?id=ZhMiN64D96cC&pg=PA234 p. 234]</ref><ref>Cina & Perper, 2010: [http://books.google.com/books?id=eHhtsODHWf0C&pg=PA95 p. 95]</ref><ref>{{Cite book|authors=Wheelis, Mark;Rózsa, Lajos; Dando, Malcolm|title=Deadly cultures: biological weapons since 1945|publisher=Harvard University Press|year=2006|isbn=9780674016996|pages=27–28|url=http://books.google.com/books?id=Usskez9NfEYC&pg=PA27}}</ref><ref>[http://www.democracynow.org/2005/7/13/how_the_u_s_government_exposed How the U.S. Government Exposed Thousands of Americans to Lethal Bacteria to Test Biological Warfare]</ref> The Chicago subway system was also subject to a similar experiment by the Army.<ref name="rogue-state-150-151" />

==Human radiation experiments==
Researchers in the United States have performed thousands of [[human radiation experiments]] to determine the effects of [[atomic radiation]] and [[radioactive contamination]] on the human body, generally on people who were poor, sick, or powerless.<ref name="textbook-research-ethics-19-23">Loue, 2000: [http://books.google.com/?id=Hizb9k7W57MC&pg=PA19 pp. 19–23]</ref> Most of these tests were performed, funded, or supervised by the [[United States military]], [[United States Atomic Energy Commission|Atomic Energy Commission]], or various other [[US federal government]] agencies.

The experiments included a wide array of studies, involving things like feeding radioactive food to mentally disabled children or [[conscientious objectors]], inserting [[radium]] rods into the noses of soldiers, deliberately releasing radioactive chemicals over U.S. and Canadian cities, measuring the health effects of radioactive fallout from nuclear bomb tests, injecting pregnant women and babies with radioactive chemicals, and irradiating the testicles of prison inmates, amongst other things.

Ultimately, public outcry over the experiments led to the 1994 [[Advisory Committee on Human Radiation Experiments]].

===Radioactive iodine experiments===
In 1953, the [[U.S. Atomic Energy Commission]] (AEC) ran several studies on the health effects of radioactive iodine in newborns and pregnant women at the [[University of Iowa]]. In one study, researchers gave pregnant women from 100 to 200 microcuries of iodine-131, in order to study the women's [[miscarriage|aborted embryos]] in an attempt to discover at what stage, and to what extent, radioactive iodine crosses the [[placental]] barrier. In another study, they gave 25 newborn babies (who were under 36 hours old and weighed from 5.5 to 8.5&nbsp;lbs) iodine-131, either by oral administration or through an injection, so that they could measure the amount of iodine in their thyroid glands.<ref name="goliszek-132-134" />

In another AEC study, researchers at the [[University of Nebraska College of Medicine]] fed iodine-131 to 28 healthy infants through a gastric tube to test the concentration of iodine in the infants' thyroid glands.<ref name="goliszek-132-134">Goliszek, 2003: pp. 132-134</ref>

In a 1949 operation called the "[[Green Run]]," the AEC released iodine-131 and [[xenon-133]] to the atmosphere which contaminated an {{convert|500000|acre|km2|adj=on}} area containing three small towns near the [[Hanford site]] in Washington.<ref name="goliszek-130-131">Goliszek, 2003: pp. 130-131</ref>

In 1953, the AEC sponsored a study to discover if radioactive iodine affected [[premature birth|premature]] babies differently from full-term babies. In the experiment, researchers from Harper Hospital in [[Detroit]] orally administered iodine-131 to 65 premature and full-term infants who weighed from 2.1 to {{convert|5.5|lb|abbr=on}}.<ref name="goliszek-132-134" />

In 1962, the Hanford site again released I-131, stationing test subjects along its path to record its effect on them. The AEC also recruited Hanford volunteers to ingest milk contaminated with I-131 during this time.<ref name="goliszek-132-134" />

===Uranium experiments===
Between 1946 and 1947, researchers at the [[University of Rochester]] injected [[uranium-234]] and [[uranium-235]] in dosages ranging from 6.4 to 70.7 [[micrograms]] per [[kilogram]] of [[body weight]] into six people to study how much uranium their kidneys could tolerate before becoming damaged.<ref name="goliszek-136-137">Goliszek, 2003: pp. 136-137</ref>

Between 1953 and 1957, at the [[Massachusetts General Hospital]], Dr. William Sweet injected eleven terminally ill, comatose and semi-comatose patients with uranium in an experiment to determine, among other things, its viability as a [[chemotherapy]] treatment against [[brain tumors]], which all but one of the patients had (one being a mis-diagnosis). Dr. Sweet, who died in 2001, maintained that consent had been obtained from the patients and next of kin.<ref name="undue-risk-132">Moreno, 2001: [http://books.google.com/?id=ZhMiN64D96cC&pg=PA132 p. 132]</ref><ref name="lebaron-109-111">{{Cite book|last=LeBaron|first=Wayne D.|title=America's nuclear legacy|publisher=Nova Publishers|year=1998|pages=109–111|isbn=9781560725565|url=http://books.google.com/?id=cr81ZHY-6H0C&pg=PA109&dq=massachusetts+general+hospital+uranium&cd=16#v=onepage&q=massachusetts%20general%20hospital%20uranium}}</ref>

===Plutonium experiments===
<!--Please expand this section -- I recommend using Welsome, Eileen "The Plutonium Files" -- Jrtayloriv -->

In 1945, as part of the [[Manhattan Project]], three patients at Billings Hospital at the [[University of Chicago]] were injected with plutonium.<ref name="pfiles-146-148">{{Cite book|title=The Plutonium Files: America's Secret Medical Experiments in the Cold War|author=Eileen Welsome|publisher=Dial Press|location=New York|year=1999|isbn=0-385-31402-7|pages=146–148}}</ref>

In 1946, six employees of a Chicago [[metallurgical]] lab were given water that was contaminated with [[plutonium-239]], so that researchers could study how plutonium is absorbed into the [[digestive tract]].<ref name="goliszek-136-137" />

===Experiments involving other radioactive materials===
Immediately after World War II, researchers at [[Vanderbilt University]] gave 829 pregnant mothers in Tennessee what they were told were "vitamin drinks" that would improve the health of their babies, but were, in fact, mixtures containing radioactive iron, to determine how fast the radioisotope crossed into the [[placenta]]. At least three children are known to have died from the experiments, from cancers and leukemias.<ref name="lebaron-97-98" /><ref>Pacchioli, David, (March 1996) [http://www.rps.psu.edu/mar96/science.html "Subjected to Science"], ''Research/Penn State'', Vol. 17, no. 1</ref> Four of the women's babies died from cancers as a result of the experiments, and the women experienced rashes, bruises, anemia, hair/tooth loss, and cancer.<ref name="textbook-research-ethics-19-23" />

From 1946 to 1953, at the [[Walter E. Fernald State School]] in Massachusetts, in an experiment sponsored by the U.S. Atomic Energy Commission and the [[Quaker Oats]] corporation, 73 mentally disabled children were fed [[oatmeal]] containing radioactive [[calcium]] and other [[radionuclide|radioisotope]]s, in order to track "how nutrients were digested". The children were not told that they were being fed radioactive chemicals and were told by hospital staff and researchers that they were joining a "science club".<ref name="lebaron-97-98">{{Cite book|last=LeBaron|first=Wayne D.|title=America's nuclear legacy|publisher=Nova Publishers|year=1998|pages=97–98|isbn=9781560725565|url=http://books.google.com/?id=cr81ZHY-6H0C&pg=PA97&dq=human+radiation+experiments&cd=2#v=onepage&q=human%20radiation%20experiments}}</ref><ref name="goliszek-139">Goliszek, 2003: p. 139</ref><ref>{{cite news | url = http://www.cbsnews.com/stories/2004/04/29/60minutes/main614728.shtml | accessdate = February 18, 2010 | work=CBS News | title=America's Deep, Dark Secret | date=April 29, 2004}}</ref><ref name=" Task Force Reports on Fernald Studies">{{Cite book|title=The Tech online edition |author= Abhilash R. Vaishnav| publisher=The Tech |year=1994 |url=http://tech.mit.edu/V114/N28/fernald.28n.html}}</ref>

In the 1950s, researchers at the Medical College of Virginia performed experiments on severe burn victims, most of them poor and black, without their knowledge or consent, with funding from the Army and in collaboration with the AEC. In the experiments, the subjects were exposed to additional burning, experimental antibiotic treatment, and injections of radioactive isotopes. The amount of radioactive [[phosphorus-32]] injected into some of the patients, 500 microcuries, was 50 times the "acceptable" dose for a ''healthy'' individual; for people with severe burns, this likely led to significantly increased death rates.<ref>[http://www.gwu.edu/~nsarchiv/radiation/dir/mstreet/commeet/meet11/trnsc11a.txt "Transcript - February 15, 1995"], ''Eleventh Meeting, February 19–20, 1995 - Washington D.C.'', [[Advisory Committee on Human Radiation Experiments]] (accessed: 02/19/2010) – see testimony of Honicker</ref><ref name="man-med-state-263">Eckart, 2006: [http://books.google.com/?id=VIEDR5XLrWsC&pg=PA263&lpg=PA263 p. 263]</ref>

Between 1948 and 1954, funded by the federal government, researchers at the [[Johns Hopkins Hospital]] inserted radium rods into the noses of 582 [[Baltimore, Maryland]] schoolchildren as an alternative to [[adenoidectomy]].<ref name="health-fallout">Cherbonnier, Alice (October 1, 1997) [http://www.baltimorechronicle.com/rupnose.html "Nasal Radium Irradiation of Children Has Health Fallout"], ''Baltimore Chronicle and Sentinel'' (accessed: 02/19/2010)</ref><ref>{{cite journal|title=The Verdict: No harm, no foul|author=Danielle Gordon|work=Bulletin of the Atomic Scientists|volume=52|issue=1|date=January 1996|url=http://books.google.com/books?id=ywwAAAAAMBAJ&pg=PA32}}</ref><ref>{{cite web|title=Nasal Radium Irradiation: Bad Science, Bad Medicine, Bad Ethics|author=Stewart A. Farber|work=Testimony to U.S. Senate Committee on Governmental Affairs (ACHRE hearings)|date=March 12, 1996|url=http://books.google.com/books?id=smhFRTC3jqEC&pg=PA75}}</ref> Similar experiments were performed on over 7,000 U.S. Army and Navy personnel during World War II.<ref name="health-fallout" /> It went on to become a standard medical treatment and was used in over two and a half million Americans.<ref name="health-fallout" />

In another study at the Walter E. Fernald State School, in 1956, researchers gave mentally disabled children radioactive calcium orally and intravenously. They also injected radioactive chemicals into malnourished babies and then pushed needles through their skulls, into their brains, through their necks, and into their spines to collect [[cerebrospinal fluid]] for analysis.<ref name=" Task Force Reports on Fernald Studies" /><ref name="goliszek-253">Goliszek, 2003: p. 253</ref>

An eighteen-year-old woman at an upstate New York hospital, expecting to be treated for a [[pituitary gland]] disorder, was injected with [[plutonium]].<ref>[http://www.democracynow.org/2004/5/5/plutonium_files_how_the_u_s "Plutonium Files: How the U.S. Secretly Fed Radioactivity to Thousands of Americans"], ''Democracy Now!'', May 5, 2004</ref>

In 1961 and 1962, ten Utah State Prison inmates had blood samples taken which were then mixed with radioactive chemicals and reinjected back into their bodies.<ref name="lebaron-105">{{Cite book|last=LeBaron|first=Wayne D.|title=America's nuclear legacy|publisher=Nova Publishers|year=1998|page=105|isbn=9781560725565|url=http://books.google.com/?id=cr81ZHY-6H0C&pg=PA105&dq=human+radiation+experiments&cd=2#v=onepage&q=human%20radiation%20experiments}}</ref>

In a 1967 study that was published in the ''Journal of Clinical Investigation'', pregnant women were injected with radioactive [[cortisol]] to see if it would cross the placental barrier and affect the [[fetuses]].<ref name="goliszek-223-225" />

===Fallout research===
[[File:Project 4.1 final report cover.png|thumb|right|200px|Cover of the final report of [[Project 4.1]], which examined the effects of [[radioactive fallout]] on the natives of the [[Marshall Islands]]]]
In 1954, American scientists conducted [[Nuclear fallout|fallout]] exposure research on the citizens of the [[Marshall Islands]] after they were inadvertently irradiated<ref>{{cite web|title=Operation Castle|url=http://nuclearweaponarchive.org/Usa/Tests/Castle.html|work=Operation Castle|accessdate=6/11/2011}}</ref> by the [[Castle Bravo]] [[nuclear test]] in [[Project 4.1]]. The Bravo test was detonated upwind of [[Rongelap Atoll]] and the residents were exposed to serious radiation levels, up to 180 rads. Of the 236 Marshallese exposed, some developed severe [[radiation sickness]] and one died, and long term effects included birth defects, "jellyfish" babies, and thyroid problems.<ref>[http://www.rmiembassyus.org/Nuclear%20Issues.htm Nuclear Issues]</ref>

In 1957, atmospheric nuclear explosions in Nevada, which were part of [[Operation Plumbbob]] were later determined to have released enough radiation to have caused from 11,000 to 212,000 excess cases of [[thyroid cancer]] amongst U.S. citizens who were exposed to [[fallout]] from the explosions, leading to between 1,100 and 21,000 deaths.<ref name="plumbbob-thyroid-cancer-nci">{{Cite book|title=Exposure of the American people to Iodine-131 from Nevada nuclear-bomb tests: review of the National Cancer Institute report and public health implications|editor=Institute of Medicine (U.S.). Committee on Thyroid Screening Related to I-131 Exposure, National Research Council (U.S.). Committee on Exposure of the American People to I-131 from the Nevada Atomic Bomb Tests|publisher=National Academies Press|year=1999|pages=113–114|isbn=9780309061759|url=http://books.google.com/?id=vGtce6RjjM0C&pg=PA114}} – deaths taken from 90% survival rate, applied to # of cases</ref>

Early in the [[Cold War]], in studies known as [[Project GABRIEL]] and [[Project SUNSHINE]], researchers in the United States, the [[United Kingdom]], and [[Australia]] attempted to determine just how much nuclear fallout would be required to make the Earth uninhabitable.<ref>[http://www.hss.energy.gov/healthsafety/ohre/roadmap/achre/intro_7.html ''ACHRE Report:New Ethical Questions for Medical Researchers'']<br>"In 1949, the AEC undertook [[Project Gabriel]], a secret effort to study the question of whether the tests could threaten the viability of life on earth. In 1953, Gabriel led to Project Sunshine..."</ref><ref>[[U.S. Department of Energy]], ''[http://www.hss.energy.gov/HealthSafety/IHS/marshall/collection/data/ihp1b/5674_.pdf "Report on Project Gabriel"]'', July 1954</ref> They realized that atmospheric [[nuclear testing]] had provided them an opportunity to investigate this. Such tests had dispersed [[radioactive contamination]] worldwide, and examination of human bodies could reveal how readily it was taken up and hence how much damage it caused. Of particular interest was [[strontium]]-90 in the bones. Infants were the primary focus, as they would have had a full opportunity to absorb the new contaminants.<ref>{{cite news | url = http://www.guardian.co.uk/Archive/Article/0,4273,4197264,00.html | location=London | work=The Guardian | first=Eddie | last=Goncalves | title=Britain snatched babies' bodies for nuclear labs | date=June 3, 2001}}</ref>

As a result of this conclusion, researchers began a program to collect human bodies and bones from all over the world, with a particular focus on infants. The bones were cremated and the ashes analyzed for radioisotopes. This project was kept secret primarily because it would be a [[public relations]] disaster; as a result parents and family were not told what was being done with the body parts of their relatives.<ref>[http://www.sehd.scot.nhs.uk/scotorgrev/Documents/Project%20Sunshine%20%20slippery%20slope.pdf Dundee University Medical School; PDF]</ref>

===Irradiation experiments===
Between 1960 and 1971, the Department of Defense funded non-consensual [[whole body radiation]] experiments on poor, black cancer patients, who were not told what was being done to them. Patients were told that they were receiving a "treatment" that might cure their cancer, but in reality the Pentagon was attempting to determine the effects of high levels of radiation on the human body. One of the doctors involved in the experiments, Robert Stone, was worried about [[litigation]] by the patients, so he only referred to them by their initials on the medical reports. He did this so that, in his words, "there will be no means by which the patients can ever connect themselves up with the report", in order to prevent "either adverse publicity or litigation".<ref name="lebaron-99-100">{{Cite book|last=LeBaron|first=Wayne D.|title=America's nuclear legacy|publisher=Nova Publishers|year=1998|pages=99–100|isbn=9781560725565|url=http://books.google.com/?id=cr81ZHY-6H0C&pg=PA99&dq=human+radiation+experiments&cd=2#v=onepage&q=human%20radiation%20experiments}}</ref>

From 1960 to 1971, [[Dr. Eugene Saenger]], funded by the Defense Atomic Support Agency, performed whole body radiation experiments on more than 90 poor, black, terminally ill cancer patients with inoperable tumors at the University of Cincinnati Medical Center. He forged consent forms, and did not inform them of the risks of irradiation. The patients were given 100 or more rads of whole-body radiation, which in many caused intense pain and vomiting. Critics have questioned the medical rationale for this study, and contend that the main purpose of the research was to study the acute effects of radiation exposure.<ref name="saenger">Thomas H. Maugh II, [http://articles.latimes.com/2007/oct/06/local/me-saenger6 "Eugene Saenger, 90; physician conducted pivotal studies on effects of radiation exposure"], ''Los Angeles Times'', October 06, 2007 (accessed: February 18, 2010)</ref><ref>[http://www.netti.fi/~makako/mind/radkill.htm Human Experiments]</ref>

From 1963 to 1973, a leading [[endocrinologist]], Dr. Carl Heller, [[irradiation|irradiated]] the testicles of [[Oregon]] and [[Washington (U.S. state)|Washington]] prisoners. In return for their participation, he gave them $5 a month, and $100 when they had to receive a [[vasectomy]] upon conclusion of the trial. The surgeon who sterilized the men said that it was necessary to "keep from contaminating the general population with radiation-induced [[mutant]]s". One of the researchers who had worked with Heller on the experiments, Dr. Joseph Hamilton, said that the experiments "had a little of the [[Buchenwald]] touch".<ref name="whiteout-157-159">{{Cite book|last=Cockburn|first=Alexander|coauthors=Jeffrey St. Clair|title=Whiteout: The CIA, Drugs and the Press|publisher=Verso|location=New York|year=1998|pages=157–159|isbn=1859842585|url=http://books.google.com/?id=s5qIj_h_PtkC&pg=PA157&dq=heller+oregon+testicles&cd=9#v=onepage&q=heller%20oregon%20testicles}}</ref>

In 1963, [[University of Washington]] researchers [[irradiation|irradiated]] the [[testes]] of 232 prisoners to determine the effects of radiation on testicular function. When these inmates later left prison and had children, at least four of them had offspring born with [[birth defects]]. The exact number is unknown because researchers never followed up on the status of the subjects.<ref name="goliszek">Goliszek, 2003: Ch. 4</ref>

==Chemical experiments==
From 1942 to 1944, the U.S. [[Chemical Warfare Service]] conducted experiments which exposed thousands of U.S. military personnel to [[mustard gas]], in order to test the effectiveness of gas masks and protective clothing.<ref>Moreno, 2001: [http://books.google.com/books?id=ZhMiN64D96cC&pg=PA40 pp. 40-43]</ref><ref>{{Cite journal|author=Freeman, Karen|title=The Unfought Chemical War|work=Bulletin of the Atomic Scientists|date=December 1991|pages=30–39|url=http://books.google.com/books?id=rQwAAAAAMBAJ&pg=PA30}}</ref><ref>{{cite book|editors=Pechura, Constance M. & Rall, David P.|title=Veterans at Risk: the health effects of mustard gas and Lewisite|year=1993|publisher=National Academies Press|isbn=9780309048323|page=31|url=http://books.google.com/books?id=UMJw_6sx1jIC&pg=PA31}}</ref><ref>Cina & Perper, 2010: [http://books.google.com/books?id=eHhtsODHWf0C&pg=PA96 p. 96]</ref>

From 1950 through 1953, the US Army sprayed toxic chemicals over six cities in the United States and Canada, in order to test dispersal patterns of chemical weapons. Army records stated that the chemicals which were sprayed on the city of [[Winnipeg, Canada]], included [[zinc cadmium sulfide]].<ref>{{Cite book|title=Plague wars: a true story of biological warfare|last1=Mangold|first1=Tom|last2=Goldberg|first2=Jeff|publisher=Macmillan|year=2000|isbn=9780312203535|page=37|url=http://books.google.com/books?id=y69nhn-9FqcC&pg=PA37}}</ref>

To test whether or not [[sulfuric acid]], which is used in making [[molasses]], was harmful as a food additive, the Louisiana State Board of Health commissioned a study to feed "Negro prisoners" nothing but molasses for five weeks. One report stated that prisoners didn't "object to submitting themselves to the test, because it would not do any good if they did".<ref name="acres-skin-76-77">Hornblum, 1998: [http://books.google.com/?id=HyFbdu7KKswC&pg=PA76 pp. 76-77]</ref>

A 1953 article in the medical/scientific journal ''Clinical Science''<ref>B.M. Ansell, F. Antonini, L.E. Glynn: "Cantharides blisters in children with rheumatic fever". ''Clinical Science'', November 1953, 12 (4): 367-373.</ref> described a medical experiment in which researchers intentionally blistered the skin on the [[abdomens]] of 41 children, who ranged in age from 8 to 14, using [[cantharide]]. The study was performed to determine how severely the substance injures/irritates the skin of children. After the studies, the children's blistered skin was removed with scissors and swabbed with peroxide.<ref name="goliszek-223-225" />

[[File:Chloracne-in-herbicide-worker.gif|thumb|right|180px|[[Chloracne]] resulting from exposure to [[Polychlorinated dibenzodioxins|dioxins]], such as those that Albert Kligman injected into prisoners at the [[Holmesburg Prison]]]]
From approximately 1951 to 1974, the [[Holmesburg Prison|Holmesburg State Prison]] in [[Pennsylvania]] was the site of extensive [[dermatological]] research operations, using prisoners as subjects. Led by Dr. Albert M. Kligman of the [[University of Pennsylvania]], the studies were performed on behalf of [[Dow Chemical Company]], the U.S. Army, and [[Johnson & Johnson]].<ref>Hornblum, 1998: [http://books.google.com/books?id=NGCLMQF85SkC&pg=PA216 p. 216]</ref><ref>Cina & Perper, 2010: [http://books.google.com/books?id=WWJUGMh2OhcC&pg=PA92 pp. 92-93]</ref><ref>Washington, 2008: [http://books.google.com/books?id=apGhwRt6A7QC&pg=PA249 pp. 249-262]</ref> In one of the studies, for which Dow Chemical paid Kligman $10,000, Kligman injected [[Polychlorinated dibenzodioxins|dioxin]]—a highly toxic, [[carcinogenic]] component of [[Agent Orange]], which Dow was manufacturing for use in Vietnam at the time—into 70 prisoners (most of them black). The prisoners developed severe lesions which went untreated for seven months.<ref name="germ-war" /> Dow Chemical wanted to study the health effects of dioxin and other [[herbicides]], and how they affect human skin, because workers at their chemical plants were developing [[chloracne]]. In the study, Kligman applied roughly the amount of dioxin Dow employees were being exposed to. In 1980 and 1981, some of the people who were used in this study sued Professor Kligman for a variety of health problems, including [[Systemic lupus erythematosus|lupus]] and psychological damage.<ref name="kaye-wrinkled">Kaye, Jonathan. "Retin-A's Wrinkled Past", ''Pennsylvania History Review'', Spring 1997.</ref>

Kligman later continued his dioxin studies, increasing the dosage of dioxin he applied to 10 prisoners' skin to 7,500 micrograms of dioxin, which is 468 times the dosage that the Dow Chemical official Gerald K. Rowe had authorized him to administer. As a result, the prisoners developed inflammatory [[pustules]] and [[papules]].<ref name="kaye-wrinkled" />

The Holmesburg program also paid hundreds of inmates a nominal stipend to test a wide range of cosmetic products and chemical compounds, whose health effects were unknown at the time.<ref name="acres-320">Hornblum, 1998: [http://books.google.com/?id=HyFbdu7KKswC&pg=PA320 p. 320]</ref><ref>{{Cite news|title = Ex-Inmates Sue Penn and Kligman over Research |newspaper = The Pennsylvania Gazette|publisher = [[The University of Pennsylvania]] |date = Jan/Feb 2001| url = http://www.upenn.edu/gazette/0101/0101gaz3.html |accessdate = 9 November 2009}}</ref> Upon his arrival at Holmesberg, Kligman is claimed to have said "All I saw before me were acres of skin ... It was like a farmer seeing a fertile field for the first time".<ref>Hornblum, 2007: p. 52</ref> It was reported in a 1964 issue of ''Medical News'' that 9 out of 10 prisoners at Holmesburg Prison were medical test subjects.<ref name="goliszek-226">Goliszek, 2003: p. 226</ref>

In 1967, the U.S. Army paid Kligman to apply skin-blistering chemicals to the faces and backs of inmates at Holmesburg to, in Kligman's words, "learn how the skin protects itself against chronic assault from toxic chemicals, the so-called hardening process."<ref name="kaye-wrinkled" />

==Psychological and torture experiments==
===U.S. government research===
The United States government funded and performed numerous psychological experiments, especially during the [[Cold War]] era. Many of these experiments were performed to help develop more effective [[torture]] and [[interrogation]] techniques for the U.S. military and intelligence agencies, and to develop techniques for resisting torture at the hands of enemy nations and organizations.

In studies running from 1947 to 1953, which were known as [[Project Chatter]], the U.S. Navy began identifying and testing [[truth serums]], which they hoped could be used during interrogations of Soviet spies. Some of the chemicals tested on human subjects included [[mescaline]] and the [[anticholinergic]] drug [[scopolamine]].<ref name="goliszek-152-154">Goliszek, 2003: pp. 152-154</ref>

Shortly thereafter, in 1950, the CIA initiated [[Project Bluebird]], later renamed [[Project Artichoke]], whose stated purpose was to develop "the means to control individuals through special interrogation techniques", "way<nowiki>[s]</nowiki> to prevent the extraction of information from CIA agents", and "offensive uses of unconventional techniques, such as hypnosis and drugs".<ref name="goliszek-152-154" /><ref>[http://www.gwu.edu/~nsarchiv/NSAEBB/NSAEBB54/ Science, Technology and the CIA]</ref><ref>''Church Committee''; [http://www.aarclibrary.org/publib/church/reports/book1/html/ChurchB1_0199b.htm p. 390] "MKULTRA was approved by the DCI <nowiki>[</nowiki>Director of Central Intelligence] on April 13, 1953"</ref> The purpose of the project was outlined in a memo dated January 1952 that stated, "Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature, such as self preservation?" The project studied the use of [[hypnosis]], forced [[morphine]] [[Substance dependence|addiction]] and subsequent forced [[heroin withdrawal|withdrawal]], and the use of other chemicals, among other methods, to produce amnesia and other vulnerable states in subjects.<ref>Estabrooks, G.H. Hypnosis comes of age. Science Digest, 44-50, April 1971</ref><ref>Gillmor, D. ''I Swear By Apollo: Dr. Ewen Cameron and the CIA-Brainwashing Experiments''. Montreal: Eden press, 1987.</ref><ref>Scheflin, A.W., & Opton, E.M. ''The Mind manipulators''. New York: Paddington Press, 1978.</ref><ref>Thomas, G. ''Journey into Madness: The Secret Story of Secret CIA Mind Control and Medical Abuse''. New York: Bantam, 1989 (paperback 1990).</ref><ref>Weinstein, H. ''Psychiatry and the CIA: Victims of Mind Control''. Washington, DC: American Psychiatric Press, 1990.</ref> In order to "perfect techniques for the abstraction of information from individuals, whether willing or not", Project Bluebird researchers experimented with a wide variety of psychoactive substances, including [[LSD]], [[heroin]], [[marijuana]], [[cocaine]], [[phencyclidine|PCP]], [[mescaline]], and [[ether]].<ref name="american-torture-23">Otterman, 2007: [http://books.google.com/?id=wiVqrgS68NoC&pg=PA23 p. 23]</ref> Project Bluebird researchers dosed over 7,000 U.S. military personnel with [[LSD]], without their knowledge or consent, at the [[Edgewood Arsenal]] in [[Maryland]]. More than 1,000 of these soldiers suffered from several psychiatric illnesses, including [[major depressive disorder|depression]] and [[epilepsy]], as a result of the tests. Many of them tried to commit [[suicide]].<ref name="american-torture-21-22">Otterman, 2007: [http://books.google.com/?id=wiVqrgS68NoC&pg=PA21 pp. 21-22]</ref>

In 1952, professional tennis player [[Harold Blauer]] died when injected with a fatal dose of a mescaline derivative at the New York State Psychiatric Institute of [[Columbia University]], by Dr. James Cattell. The [[United States Department of Defense]], which sponsored the injection, worked in collusion with the Department of Justice, and the New York State Attorney General to conceal evidence of its involvement for 23 years. Cattell claimed that he did not know what the army had given him to inject into Blauer, saying: "''We didn't know whether it was dog piss or what we were giving him.''"<ref>{{Cite book|title=The secret histories: hidden truths that challenged the past and changed the world|isbn=9780312425173|publisher=Macmillan|year=2005|editor=John S. Friedman|url=http://books.google.com/?id=wERx-0P2HPsC&pg=PA146&dq=Henry+blauer+mescaline&cd=1#v=onepage&q=Henry%20blauer%20mescaline|page=146}}</ref><ref>Cole, 1996: [http://books.google.com/?id=TL0mhQwi7gYC&pg=PA31 pp. 31-32]</ref>

In 1953, the CIA placed several of its interrogation and mind-control programs under the direction of a single program, known by the code name [[MKULTRA]], after CIA director [[Allen Dulles]] complained about not having enough "human guinea pigs to try these extraordinary techniques".<ref name="question-torture-28-30">McCoy, 2006: [http://books.google.com/?id=-sa-nUI3HGMC&pg=PA28 pp. 28-30]</ref> The MKULTRA project was under the direct command of [[Dr. Sidney Gottlieb]] of the [[Technical Services Division]].<ref name="question-torture-28-30" /> The project received over $25 million, and involved hundreds of experiments on human subjects at eighty different institutions.

In a memo describing the purpose of one MKULTRA program subprogram, Richard Helms said:
{{blockquote|We intend to investigate the development of a chemical material which causes a reversible, nontoxic aberrant mental state, the specific nature of which can be reasonably well predicted for each individual. This material could potentially aid in discrediting individuals, eliciting information, and implanting suggestions and other forms of mental control.|Richard Helms, internal CIA memo<ref name="goliszek-155">Goliszek, 2003: [http://books.google.com/books?id=jzbcSdD9RG4C&pg=155 p. 155]</ref>}}

In 1954, the CIA's Project QKHILLTOP was created to study Chinese [[brainwashing]] techniques, and to develop effective methods of interrogation. Most of the early studies are believed to have been performed by the [[Cornell University]] Medical School's human ecology study programs, under the direction of Dr. Harold Wolff.<ref name="goliszek-152-154" /><ref>[http://www.druglibrary.org/schaffer/history/e1950/mkultra/AppendixC.htm APPENDIX C: Documents Referring To Subprojects] – ''1977 Senate MKULTRA Hearing'' (accessed: 02/18/2010)</ref><ref name="american-torture-24-25">Otterman, 2007: [http://books.google.com/?id=wiVqrgS68NoC&pg=PA24 pp. 24-25]</ref> Wolff requested that the CIA provide him any information they could find regarding "threats, coercion, imprisonment, deprivation, humiliation, torture, 'brainwashing', 'black psychiatry', and hypnosis, or any combination of these, with or without chemical agents". According to Wolff, the research team would then:
{{blockquote|...assemble, collate, analyze and assimilate this information and will then undertake experimental investigations designed to develop new techniques of offensive/defensive intelligence use ... Potentially useful secret drugs (and various [[brain damage|brain damaging]] procedures) will be similarly tested in order to ascertain the fundamental effect upon human brain function and upon the subject's mood ... Where any of the studies involve potential harm of the subject, we expect the Agency to make available suitable subjects and a proper place for the performance of the necessary experiments.|Dr. Harold Wolff, Cornell University Medical School<ref name="american-torture-24-25" />}}

{{Quote box|quote='''''... it was fun, fun, fun. Where else could a red-blooded American boy lie, kill, cheat, steal, rape and pillage with the sanction and bidding of the All-highest?'''''|source=George Hunter White, who oversaw drug experiments for the CIA as part of [[Operation Midnight Climax]]<ref name="whiteout-206-209" />|width=25%}}
Another of the MKULTRA subprojects, [[Operation Midnight Climax]], consisted of a web of CIA-run safehouses in San Francisco, Marin, and New York which were established in order to study the effects of LSD on unconsenting individuals. Prostitutes on the CIA payroll were instructed to lure clients back to the safehouses, where they were surreptitiously plied with a wide range of substances, including LSD, and monitored behind one-way glass. Several significant operational techniques were developed in this theater, including extensive research into sexual blackmail, surveillance technology, and the possible use of mind-altering drugs in field operations.<ref name="whiteout-206-209">{{Cite book|last=Cockburn|first=Alexander|coauthors=Jeffrey St. Clair|title=Whiteout: The CIA, Drugs and the Press|publisher=Verso|location=New York|year=1998|pages=206–209|isbn=1859842585}}</ref>

In 1957, with funding from a CIA front organization, [[Dr. Ewan Cameron]] of the [[Allan Memorial Institute]] in [[Montreal, Canada]] began MKULTRA Subproject 68.<ref name="american-torture-45-47">Otterman, 2007: [http://books.google.com/?id=wiVqrgS68NoC&pg=PA45 pp. 45-47]</ref> His experiments were designed to first "depattern" individuals, erasing their minds and memories—reducing them to the mental level of an infant—and then to "rebuild" their personality in a manner of his choosing.<ref name="shock-doc-ch1" /> To achieve this, Cameron placed patients under his "care" into drug-induced comas for up to 88 days, and applied numerous high voltage electric shocks to them over the course of weeks or months, often administering up to 360 shocks per person. He would then perform what he called "psychic driving" experiments on the subjects, where he would repetitively play recorded statements, such as "You are a good wife and mother and people enjoy your company", through speakers he had implanted into blacked-out football helmets that he bound to the heads of the test subjects (for [[sensory deprivation]] purposes). The patients could do nothing but listen to these messages, played for 16–20 hours a day, for weeks at a time. In one case, Cameron forced a person to listen to a message non-stop for 101 days.<ref name="shock-doc-ch1" /> Using CIA funding, Cameron converted the horse [[stables]] behind Allen Memorial into an elaborate isolation and sensory deprivation chamber which he kept patients locked in for weeks at a time.<ref name="shock-doc-ch1" /> Cameron also induced [[insulin]] comas in his subjects by giving them large injections of insulin, twice a day for up to two months at a time.<ref name="goliszek-152-154"/> Several of the children who Cameron experimented on were sexually abused, in at least one case by several men. One of the children was filmed numerous times performing sexual acts with high-ranking federal government officials, in a scheme set up by Cameron and other MKULTRA researchers, to blackmail the officials to ensure further funding for the experiments.<ref name="goliszek-170-171">Goliszek, 2003: pp. 170-171</ref>

{{Quote box|quote='''''The frequent screams of the patients that echoed through the hospital did not deter Cameron or most of his associates in their attempts to depattern their subjects completely'''''|source=John D. Marks, ''The Search for the Manchurian Candidate'', [http://www.druglibrary.org/schaffer/LSD/marks8.htm Chapter 8]<ref name="manchurian-ch8">Marks, John D., [http://www.druglibrary.org/schaffer/LSD/marks8.htm Chapter 8], ''The Search for the Manchurian Candidate''</ref>|width=25%}}

The CIA leadership had serious concerns about their unethical and illegal behavior, as evidenced in a 1957 [[CIA Inspector General|Inspector General]] Report, which stated:
{{blockquote|Precautions must be taken not only to protect operations from exposure to enemy forces but also to conceal these activities from the American public in general. The knowledge that the agency is engaging in unethical and illicit activities would have serious repurcussions in political and diplomatic circles ...|1957 CIA [[CIA Inspector General|Inspector General]] Report<ref name="american-torture-27">Otterman, 2007: [http://books.google.com/?id=wiVqrgS68NoC&pg=PA27 p. 27]</ref>}}

In 1957, Dr. Robert Heath of [[Tulane University]] performed experiments on [[schizophrenic]] patients, which were funded by the U.S. Army. In the studies, he dosed them with high levels of LSD, and then implanted "deep electrodes" in their brains to take EEG readings.<ref name="tulane-123">{{Cite book|last=Mohr|first=Clarence L.|coauthors=Joseph E. Gordon|title=Tulane: the emergence of a modern university, 1945-1980|publisher=LSU Press|year=2001|page=123|isbn=9780807125533|url=http://books.google.com/?id=xof4BkbI1DQC&pg=PA123&lpg=PA123&dq=tulane+army+lsd+electrodes+heath&q=tulane%20army%20lsd%20electrodes%20heath}}</ref>

MKULTRA activities continued until 1973 when CIA director [[Richard Helms]], fearing that they would be exposed to the public, ordered the project terminated, and all of the files destroyed.<ref name="question-torture-28-30" /> However, a clerical error had sent many of the documents to the wrong office, so when CIA workers were destroying the files, some of them remained, and were later released under a [[Freedom of Information Act]] request by [[investigative journalist]] John Marks. Many people in the American public were outraged when they learned of the experiments, and several congressional investigations took place including the [[Church Committee]] and the [[United States President's Commission on CIA activities within the United States|Rockefeller Commission]].

On 26 April 1976, the [[Church Committee]] of the United States Senate issued a report, "Final Report of the Select Committee to Study Governmental Operation with Respect to Intelligence Activities",<ref>http://www.archive.org/stream/finalreportofsel01unit#page/390/mode/2up</ref> In Book I, Chapter XVII, p 389 this report states:

:LSD was one the materials tested in the MKULTRA program. The final phase of LSD testing involved surreptitious administration to unwitting non-volunteer subjects in normal life settings by undercover officers of the Bureau of Narcotics acting for the CIA.

: A special procedure, designated MKDELTA, was established to govern the use of [[Project MKULTRA|MKULTRA]] materials abroad. Such materials were used on a number of occasions. Because MKULTRA records were destroyed, it is impossible to reconstruct the operational use of MKULTRA materials by the CIA overseas; it has been determined that the use of these materials abroad began in 1953, and possibly as early as 1950.<ref name="Estabrooks1971"> Estabrooks, G.H. Hypnosis comes of age. Science Digest, 44-50, April 1971 </ref><ref name="Gillmor1987">Gillmor, D. I Swear By Apollo. Dr. Ewen Cameron and the CIA-Brainwashing Experiments. Montreal: Eden press, 1987.</ref><ref name="Scheflin1978"> Scheflin, A.W., & Opton, E.M. The Mind manipulators. New York: Paddington Press, 1978.</ref><ref name="Thomas1989"> Thomas, G. Journey into Madness. The Secret Story of Secret CIA Mind Control and Medical Abuse. New York: Bantam, 1989 (paperback 1990).</ref><ref name="Weinstein1990">Weinstein, H. Psychiatry and the CIA: Victims of Mind Control. Washington, DC: American Psychiatric Press, 1990.</ref>

: Drugs were used primarily as an aid to interrogations, but MKULTRA/MKDELTA materials were also used for harassment, discrediting, or disabling purposes.<ref name="Estabrooks1971"/><ref name="Gillmor1987"/><ref name="Scheflin1978"/><ref name="Thomas1989"/><ref name="Weinstein1990"/>

In 1963, CIA had synthesized many of the findings from its psychological research into what became known as the [[KUBARK Counterintelligence Interrogation]] handbook,<ref name="question-torture-50-53">McCoy, 2006: [http://books.google.com/?id=-sa-nUI3HGMC&pg=PA50 pp. 50-53]</ref> which cited the MKULTRA studies, and other secret research programs as the scientific basis for their interrogation methods<ref name="shock-doc-ch1">{{Cite book|author=[[Naomi Klein]]|url=http://books.google.com/?id=Pse7S3Q8YYQC&lpg=PA25&dq=ewen%20cameron&pg=PA25#v=onepage&q=ewen%20cameron|title=The Shock Doctrine: The Rise of Disaster Capitalism|publisher=Metropolitan Books|location=New York|year=2007|chapter=1|isbn=0805079831}}</ref> Cameron regularly traveled around the U.S. teaching military personnel about his techniques (hooding of prisoners for sensory deprivation, prolonged isolation, humiliation, etc.), and how they could be used in interrogations. Latin American paramilitary groups working for the CIA and U.S. military received training in these psychological techniques at places like the [[School of the Americas]], and even today, many of the torture techniques developed in the [[MKULTRA]] studies and other programs are being used at U.S. military and CIA prisons such as [[Guantanamo Bay]] and [[Abu Ghraib]].<ref name="shock-doc-ch1" /><ref name="us-hist-torture">[http://www.zcommunications.org/u-s-has-a-history-of-using-torture-by-alfred-w-mccoy U.S. Has a History of Using Torture] – Alfred W. McCoy, ''Z Magazine''.</ref> In the aftermath of the Congressional hearings, major news media mainly focused on sensationalistic stories related to LSD, "mind-control", and "brainwashing", and rarely used the word "torture". This put off the image that CIA researchers were, as one author put it "a bunch of bumbling sci-fi buffoons", rather than a rational group of men who had run torture laboratories and medical experiments in major U.S. universities, and who had tortured, raped, and psychologically abused young children, driving many of them permanently insane.<ref name="shock-doc-ch1" />

From 1964 to 1968, the U.S. Army paid $386,486 to professors Albert Kligman and Herbert W. Copelan to perform experiments with mind-altering drugs on 320 inmates of [[Holmesburg Prison]]. The goal of the study was to determine the minimum effective dose of each drug needed to disable 50 percent of any given population. Kligman and Copelan initially claimed that they were unaware of any long-term health effects the drugs could have on prisoners, however, documents later revealed that this was not the case.<ref name="kaye-wrinkled" />

Medical professionals gathered and collected data on the CIA’s use of [[torture]] techniques on detainees, in order to refine those techniques, and to "to provide legal cover for torture, as well as to help justify and shape future procedures and policies", according to a report by [[Physicians for Human Rights]]. The report stated that: “Research and medical experimentation on detainees was used to measure the effects of large-volume waterboarding and adjust the procedure according to the results.” As a result of the waterboarding experiments, doctors recommended adding [[saline]] to the water “to prevent putting detainees in a coma or killing them through over-ingestion of large amounts of plain water.” Sleep deprivation tests were performed on over a dozen prisoners, in 48-, 96- and 180-hour increments. Doctors also collected data intended to help them judge the emotional and physical impact of the techniques so as to “calibrate the level of pain experienced by detainees during interrogation" and to determine if using certain types of techniques would increase a subject's "susceptibility to severe pain.". The CIA denied the allegations, claiming they never performed any experiments, and saying "The report is just wrong"; however, the U.S. government never investigated the claims.<ref>{{Cite news|author=Sheldon Richman|title=Did the CIA Conduct Medical Experiments on Detainees?|work=Counterpunch|date=June 23, 2010|url=http://www.counterpunch.org/richman06232010.html}}</ref><ref>[http://phrtorturepapers.org/?dl_id=9 Experiments in Torture: Human Subject Research and Experimentation in the “Enhanced” Interrogation Program], ''Physicians for Human Rights'', June 2010<br />See also:<br />*[http://phrtorturepapers.org/?page_id=614 Related Publications]<br />*[http://phrtorturepapers.org/?page_id=569 Outside Academic Experts Respond to Experiments in Torture]<br />*[http://phrtorturepapers.org/?p=430 Complaint to Office of Human Research Protections Regarding Evidence of CIA Violations of Common Rule]<br />*[http://www.youtube.com/watch?v=v5rNQOAEM6U Experiments in Torture (video)]</ref><ref>[http://www.democracynow.org/2010/6/8/experiments_in_torture_medical_group_accuses Experiments in Torture: Medical Group Accuses CIA of Carrying Out Illegal Human Experimentation], ''Democracy Now!'', June 08, 2010</ref><ref>[http://www.youtube.com/watch?v=O2aYvLfLIos Accounting for Torture: Being Faithful to our Values], (video) ''National Religious Campaign Against Torture'' (cited by PHR)</ref><ref>{{Cite news|work=New York Times|date=6 June 2010|url=http://www.nytimes.com/2010/06/07/world/07doctors.html|title=Medical Ethics Lapses Cited in Interrogations | first=James | last=Risen}}</ref><ref>[http://www.nybooks.com/media/doc/2010/04/22/icrc-report.pdf ICRC Report on the Treatment of Fourteen “High Value Detainees” in CIA Custody], ''International Committee of the Red Cross'', 14 February 2007</ref>

In August 2010, the U.S. weapons manufacturer [[Raytheon]] announced that it had partnered with a jail in [[Castaic, California]] in order to use prisoners as test subjects for a new non-lethal weapon system that "fires an invisible heat beam capable of causing unbearable pain."<ref>{{Cite news|title=California Jail to Test Ray Gun on Prisoners|work=[[Democracy Now!]]|date=August 23, 2010|url=http://www.democracynow.org/2010/8/23/headlines/california_jail_to_test_ray_gun_on_prisoners}}</ref>

===Academic research===
In 1939, at the Iowa Soldiers' Orphans' Home in [[Davenport, Iowa]], twenty-two children were the subjects of the so-called [[The Monster Study|"monster" experiment]]. This experiment attempted to use psychological abuse to induce children who spoke normally to stutter. The experiment was designed by Dr. Wendell Johnson, one of the nation's most prominent speech pathologists, for the purpose of testing one of his theories on the cause of stuttering.<ref name="mercnews-stutter">[http://www.ahrp.org/infomail/0601/11.php Theory improved treatment and understanding of stuttering: Ethics concerns led researchers to conceal the experiment Decades later, the experiment's victims struggle to make sense of their past], Jim Dyer, ''[[San Jose Mercury News]]'', Monday, June 11, 2001 (accessed: 02/17/2010)</ref>

In 1961, in response to the [[Nuremberg Trials]], the [[Yale University|Yale]] [[psychologist]] [[Stanley Milgram]] performed his study "Obedience to Authority Study", also known as the [[Milgram Experiment]], in order to determine if it was possible that the Nazi genocide could have resulted from millions of people who were "just following orders". The Milgram Experiment raised questions about the [[ethics]] of scientific experimentation because of the extreme emotional stress suffered by the participants, who were told, as part of the experiment, to apply electric shocks to test subjects (who were actually actors not really receiving [[electroshock|electric shocks]]).

==Pharmacological research==
At Harvard University, in the late 1940s, researchers began performing experiments where they tested [[diethylstilbestrol]], a synthetic [[estrogen]], on pregnant women at the Lying-In Hospital of the University of Chicago. The women experienced an abnormally high number of miscarriages and babies with low birth weight. None of the women were told that they were being experimented on.<ref name="textbook-research-ethics-30">Loue, 2000: [http://books.google.com/?id=Hizb9k7W57MC&pg=PA30 p. 30]</ref>

Researchers at the Laurel Children's Center in Maryland tested experimental [[acne]] medications on children, and continued their tests even after half of the children developed severe [[liver]] damage from the medications.<ref name="goliszek-223-225">Goliszek, 2003: pp. 223-225</ref>

From 1988 to 2008, the number of overseas clinical trials for drugs intended for American consumption increased by 2,000%, to approximately 6,500 trials. These trials are often conducted in areas with large numbers of poor and illiterate people who grant their consent by signing an "X" or making a thumb print on a form. These tests are rarely monitored by the FDA, and have in some cases proved deadly, such as a case where 49 babies died in [[New Delhi|New Delhi, India]] during a 30-month trial. The cost of testing in countries without safety regulations is much lower; and, due to lax or nonexistent oversight, pharmaceutical corporations (or research companies they've contracted out to) are able to more easily suppress research that demonstrates harmful effects and only report positive results.<ref>[http://www.democracynow.org/2010/12/17/deadly_medicine_fda_fails_to_regulate Deadly Medicine: FDA Fails to Regulate Rapidly Growing Industry of Overseas Drug Testing], ''Democracy Now!'', December 17, 2010</ref><ref>{{cite news|title=Deadly Medicine|author=Barlett, Donald L. & Steele, James B.|work=Vanity Fair|date=January 2011|url=http://www.vanityfair.com/politics/features/2011/01/deadly-medicine-201101?printable=true&currentPage=3#ixzz18NY8yGh9}}</ref>

==Other experiments==
The 1846 journals of Dr. Walter F. Jones of Petersburg, Virginia describe how he poured boiling water onto the backs of naked slaves afflicted with [[typhoid]] [[pneumonia]], at four-hour intervals, because he thought that this might "cure" the disease by "stimulating the capillaries".<ref name="med-apartheid-60-63">Washington, 2008: [http://books.google.com/?id=apGhwRt6A7QC&pg=PA60 pp. 60-63]</ref><ref>{{cite book|author=Savitt, Todd Lee|title=Medicine and slavery: the diseases and health care of Blacks in antebellum Virginia|year=2002|publisher=University of Illinois Press|isbn=9780252008740|page=299|url=http://books.google.com/books?id=ru_tDLLB0wMC&pg=PA299}}</ref><ref>Shamoo & Resnick, 2009: [http://books.google.com/books?id=dP7oKntCUUUC&pg=PA239 p. 239]</ref>

From early 1940 until 1953, Dr. [[Lauretta Bender]], a highly respected pediatric neuropsychiatrist who practiced at Bellevue Hospital in New York City, performed electroshock experiments on at least 100 children. The children's ages ranged from 3–12 years. Some reports indicate that she may have performed such experiments on more than 200. Electroconvulsive treatment was used on more than 500 children at Bellevue Hospital from 1942 to 1956, including Bender's experiments, and then at Creedmoor State Hospital Children's Service from 1956 to 1969. Publicly, Bender claimed that the results of the "therapy" were positive, but in private memos, she expressed frustration over mental health issues caused by the treatments.<ref>Albarelli Jr., H.P.; Kaye, Jeffrey S.; [http://www.truth-out.org/the-hidden-tragedy-cias-experiments-children62208 "The Hidden Tragedy of the CIA's Experiments on Children"], ''Truthout'', Wednesday 11 August 2010</ref> Bender would sometimes shock schizophrenic children (some less than 3 years old) twice per day, for 20 consecutive days. Several of the children became violent and suicidal as a result of the treatments.<ref>{{cite book|author=Whitaker, Robert|title=Mad in America: Bad Science, Bad Medicine, and the Enduring Mistreatment of the Mentally Ill|year=2010|publisher=Basic Books|isbn=9780465020140|page=315|url=http://books.google.com/books?id=mDqxay6-51oC&pg=PA315}}</ref>

At Willowbrook State School for the mentally retarded in Staten Island, NY, a hightly controversial medical study was carried out there between 1963 and 1966 by medical researchers Saul Krugman and Robert W. McCollum. Healthy children who were mentally retarded, were secretly intentionally inoculated, orally and by injection, with a virus that causes the hepatitis, then monitored to gauge the effects of gamma globulin in combating the resultant disease.[3] A public outcry forced the study to be discontinued after it was exposed and condemnend by Senator Robert F. Kennedy. <ref>http://www.npr.org/templates/story/story.php?storyId=87975196</ref> New York Senator Robert Kennedy and a television crew visit Willowbrook State school in Staten Island NY. "He likens the conditions at Willowbrook to that of a “snake pit,” and states that the residents of these institutions were “denied access to education and are deprived of their civil liberties.” Later that same year, he addressed a joint session of the NYS Legislature on the “dehumanizing conditions” of the State’s institutions.<ref>http://www.museumofdisability.org/newyork_timeline_1960s.asp</ref>

In 1942, the [[Harvard University]] [[biochemist]] Edward Cohn injected 64 [[Massachusetts]] prisoners with cow blood, as part of an experiment sponsored by the [[U.S. Navy]].<ref>Cina & Perper, 2010: [http://books.google.com/books?id=eHhtsODHWf0C&pg=PA92 p. 92]</ref><ref>Hornblum, 1999: p. 80</ref><ref name="cheaper-than-chimps">Dober, Gregory [http://www.prisonlegalnews.org/includes/_public/_issues/pln_2008/03pln08.pdf "Cheaper than Chimpanzees: Expanding the Use of Prisoners in Medical Experiments"], ''Prison Legal News'', VOL. 19 No. 3, March 2008</ref>

In 1950, researchers at the Cleveland City Hospital ran experiments to study changes in [[cerebrum|cerebral]] blood flow where they injected people with spinal [[anesthesia]], and inserted needles into their jugular veins and brachial arteries to extract large quantities of blood, and after massive blood loss which caused [[paralysis]] and [[fainting]], measured their [[blood pressure]]. The experiment was often performed multiple times on the same subject.<ref name="goliszek-223-225" />

In a series of studies which were published in the medical journal ''Pediatrics'', researchers from the [[University of California]] Department of Pediatrics performed experiments on 113 newborns ranging in age from 1 hour to 3 days, where they studied changes in blood pressure and blood flow. In one of the studies, researchers forced a [[catheter]] through the babies' [[umbilical arteries]] and into their [[aortas]], and then submerged their feet in ice water. In another of the studies, they strapped 50 newborn babies to a [[circumcision]] board, and then turned them upside down so that all of their blood rushed into their heads.<ref name="goliszek-223-225" />

From 1963 to 1969 as part of [[Project Shipboard Hazard and Defense]] (SHAD), the U.S. Army performed tests which involved spraying several U.S. ships with various biological and chemical warfare agents, while thousands of U.S. military personnel were aboard the ships. The personnel were not notified of the tests, and were not given any protective clothing. Chemicals tested on the U.S. military personnel included the nerve gases [[VX (nerve agent)|VX]] and [[Sarin]], toxic chemicals such as [[zinc cadmium sulfide]] and [[sulfur dioxide]], and a variety of biological agents.<ref name="rogue-state-152-154">{{Cite book|last=Blum|first=William|title=Rogue state: a guide to the world's only superpower|publisher=Zed Books|year=2006|pages=152–154|isbn=9781842778272|url=http://books.google.com/?id=oBM8UiDYz1MC&pg=PA150&lpg=PA150&dq=%22whooping+cough%22+CIA+tampa+1955&q=%22whooping%20cough%22%20CIA%20tampa%201955}}</ref>

The San Antonio Contraceptive Study was a clinical research study about the side effects of oral contraceptives published in 1971. Women came to a clinic in San Antonio for preventing pregnancies and were not told they were participating in a research study or receiving placebos. 10 of the women became pregnant while on placebos.<ref>Goldzieher JW, Moses LE, Averkin E, Scheel C, Taber BZ. A placebo-controlled double-blind crossover investigation of the side effects attributed to oral contraceptives. Fertil Steril. 1971 Sep;22(9):609-23. [http://www.ncbi.nlm.nih.gov/pubmed/4105854 “PMID4105854”]</ref><ref>Levine, Robert J. [http://books.google.com/books?id=NmkWW05RBOcC&pg=PA71 “Ethics and regulation of clinical research, 2nd ed”]. Yale University Press, 1986, p.71-72. ISBN [[Special:BookSources/0806711124]]</ref><ref>Veatch RM. [http://www.jstor.org/stable/3561863 “Experimental pregnancy: the ethical complexities of experimentation with oral contraceptives”]. Hastings Cent Rep. 1971 Jun; (1):2-3. [http://www.ncbi.nlm.nih.gov/pubmed/4137658 “PMID4137658”]</ref>

In the 2000s, artificial blood was transfused into research subjects across the United States without their consent by Northfield Labs.<ref>{{Cite news|title=Test of Controversial Artificial Blood Product a Failure|author=Brian Ross|date=May 23, 2007|work=ABC News, "The Blotter"|url=http://blogs.abcnews.com/theblotter/2007/05/test_of_controv.html}}</ref> Later studies showed the artificial blood caused a significant increase in the risk of heart attacks and death.<ref>{{Cite news|title=Experimental Blood Substitutes Unsafe, Study Finds|author=Ed Edelson|work=ABC News|date=April 28 2008{{When|date=September 2010}}|url=http://abcnews.go.com/Health/Healthday/Story?id=4741269&page=1}}</ref>

==Legal, academic and professional policy==
{{Main|Human subject research legislation in the United States}}

During the [[Nuremberg trials]], several of the Nazi doctors and scientists who were being tried for their human experiments claimed that the inspiration for their studies had come from studies that they had seen performed in the United States.<ref name="germ-war" /><ref name="textbook-research-ethics-26-29" /> In 1945, as part of [[Operation Paperclip]], the United States government recruited 1,600 Nazi scientists, many of whom had performed horrific human experimentation in Nazi concentration camps. The scientists were offered immunity from any [[war crimes]] they had committed during the course of their work for the Nazi government, in return for doing research for the United States government. Many of the Nazi scientists continued their human experimentation when they arrived in the United States.<ref name="goliszek-paperclip">Goliszek, 2003: pp. 108-109</ref><!--See other citations in [[Operation Paperclip]]-- no need to clutter article with more of them here -->

A secret AEC document dated April 17, 1947, titled ''Medical Experiments in Humans'' stated: "''It is desired that no document be released which refers to experiments with humans that might have an adverse reaction on [[public opinion]] or result in legal suits. Documents covering such fieldwork should be classified Secret.''"<ref name="goliszek-132-134"/>

At the same time, the Public Health Service was instructed to tell citizens downwind from bomb tests that the increases in cancers were due to [[neurosis]], and that women with radiation sickness, hair loss, and burned skin were suffering from "housewife syndrome".<ref name="goliszek-132-134"/>

In 1964, the [[World Medical Association]] passed the [[Declaration of Helsinki]], a set of ethical principles for the medical community regarding human experimentation.

In 1966, the [[National Institutes of Health]] (NIH) Office for Protection of Research Subjects (OPRR) was created, and issued its ''Policies for the Protection of Human Subjects'' which recommended establishing independent review bodies, which were later called [[institutional review boards]].

In 1969, [[Kentucky Court of Appeals]] Judge [[Samuel Steinfeld]] dissented in ''Strunk v. Strunk, 445 S.W.2d 145'', and made the first judicial suggestion that the [[Nuremberg Code]] should be applied to American [[jurisprudence]].

In 1974 the [[National Research Act]] established the National Commission for the Protection of Human Subjects, and mandated that the [[Public Health Service]] to come up with regulations that would protect the rights of human research subjects.

Project [[MK-ULTRA]] was first brought to wide public attention in 1975 by the [[Congress of the United States|U.S. Congress]], through investigations by the [[Church Committee]], and by a presidential commission known as the [[United States President's Commission on CIA activities within the United States|Rockefeller Commission]].<ref name="sci-tech-cia">[http://www.gwu.edu/~nsarchiv/NSAEBB/NSAEBB54/ Science, Technology, and the CIA], ''National Security Archive Electronic Briefing Book'', Jeffrey T. Richelson, Editor, September 10, 2001 (accessed: 02/18/2010)</ref><ref>[http://www.druglibrary.org/schaffer/history/e1950/mkultra/index.htm "U.S. Senate: Joint Hearing before The Select Committee on Intelligence and The Subcommittee on Health and Scientific Research of the Committee on Human Resources"], 95th Cong., 1st Sess. August 3, 1977.</ref>

In 1975, the Department of Health, Education and Welfare (DHEW) created regulation which included the recommendations laid out in the NIH's 1966 ''Policies for the Protection of Human Subjects''. Title 45 of the [[Code of Federal Regulations]], known as "The Common Rule," requires the appointment and utilization of institutional review boards (IRBs) in experiments using human subjects.

On April 18, 1979, prompted by an investigative journalist's public disclosure of the [[Tuskegee syphilis experiments]], the [[United States Department of Health, Education, and Welfare]] (later renamed to [[Health and Human Services]]) released a report entitled "''Ethical Principles and Guidelines for the Protection of Human Subjects of Research''," authored by Dan Harms, which laid out many modern guidelines for ethical medical research.

In 1987 the [[United States Supreme Court]] ruled in [[United States v. Stanley]], 483 U.S. 669, that a U.S. serviceman who was given [[LSD]] without his consent, as part of military experiments, could not sue the U.S. Army for damages.

Dissenting the verdict in ''U.S. v. Stanley'', Justice [[Sandra Day O'Connor]] stated:
<blockquote>No judicially crafted rule should insulate from liability the involuntary and unknowing human experimentation alleged to have occurred in this case. Indeed, as Justice Brennan observes, the United States played an instrumental role in the [[criminal justice|criminal prosecution]] of [[Nazism|Nazi]] officials who [[Nazi human experimentation|experimented with human subjects]] during the [[Second World War]], and the standards that the [[Nuremberg Trials|Nuremberg Military Tribunals]] developed to judge the behavior of the defendants stated that the 'voluntary consent of the human subject is absolutely essential ... to satisfy moral, ethical, and legal concepts.' If this principle is violated, the very least that society can do is to see that the victims are compensated, as best they can be, by the perpetrators.</blockquote>

On January 15, 1994, President Bill Clinton formed the [[Advisory Committee on Human Radiation Experiments]] (ACHRE). This committee was created to investigate and report the use of human beings as test subjects in experiments involving the effects of ionizing radiation in federally funded research. The committee attempted to determine the causes of the experiments, and reasons why the proper oversight did not exist, and made several recommendations to help prevent future occurrences of similar events.<ref>[http://www.eh.doe.gov/ohre/roadmap/achre/report.html Final report of ACHRE]</ref>

As of 2007, not a single U.S. government researcher had been prosecuted for human experimentation, and many of the victims of U.S. government experiments have not received compensation, or in many cases, acknowledgment of what was done to them.<ref name="handbook-whitecollar-crime">{{Cite book|title=International handbook of white-collar and corporate crime|url=http://books.google.com/?id=H5PLm3pUHeYC&pg=PA62&dq=single+researcher+%22has+been+prosecuted%22+human+experiments+united+states&q|page=62|editors=Henry N. Pontell, Gilbert Geis|publisher=Springer|year=2007|isbn=9780387341101}}</ref>

==See also==
{{col-begin}}
{{col-break}}
*[[Eugenics in the United States]]
*[[Tuskegee syphilis experiment]]
* Guantanamo Bay Prison
*[[Guatemala syphilis experiment]]
*[[Nazi human experimentation]]
*[[Japanese human experimentation]]
*[[Human subject research]]
*[[Human rights in the United States]]
*[[North Korean human experimentation]]
*[[Operation MKULTRA]]
*[[Operation May Day]]
*[[Stateville Penitentiary Malaria Study]]
*[[Research involving prisoners]]
{{col-break}}
*[[Belmont Report]]
*[[Operation LAC]]
*[[Operation Dew]]
*[[Operation Big Buzz]]
*[[Operation Drop Kick]]
*[[Henry Cotton (doctor)]]
*[[Animal research]]
*[[Operation Crossroads]]
*[[Vivisection]]
{{col-break}}
{{col-end}}

==References==
===Notes===
{{Reflist|colwidth=35em}}

===Bibliography===
<div class="references-small">
* {{Cite book|last1=Annas|first1=George J.|last2=Grodin|first2=Michael A.|authorlink1=George Annas|authorlink2=Michael Grodin|title=The Nazi doctors and the Nuremberg Code: human rights in human experimentation|publisher=Oxford University Press|year=1995|isbn=9780195101065}}
* {{Cite book|author=Brody, Baruch A.|title=The ethics of biomedical research: an international perspective|year=1998|publisher=Oxford University Press|isbn=9780195090079|url=http://books.google.com/books?id=mERfunMVv_oC}}
* {{Cite book|last1=Cina|first1=Stephen J.|last2=Perper|first2=Joshua A.|title=When Doctors Kill|publisher=Springer|year=2010|isbn=9781441913685}}
* {{cite book|last=Cole|first=Leonard A.|title=The Eleventh Plague: The Politics of Biological and Chemical Warfare|publisher=MacMillan|year=1996|isbn=9780805072143}}
* {{Cite book|author=Eckart, Wolfgang Uwe|title=Man, medicine, and the state: the human body as an object of government sponsored medical research in the 20th century|publisher=Franz Steiner Verlag|year=2006|isbn=9783515087940}}
* {{Cite book|last=Goliszek|first=Andrew|title=In The Name of Science|publisher=St. Martin's Press|location=New York|year=2003|isbn=9780312303563}}
* {{Cite book|editors=Grodin, Michael A. & Glantz, Leonard H.|title=Children as research subjects: science, ethics, and law|publisher=Oxford University Press US|year=1994|isbn=9780195071030}}
* {{Cite book|author=Halpern, Sydney A.|title=Lesser Harms: The Morality of Risk in Medical Research|year=2006|publisher=University of Chicago Press|isbn=9780226314525|url=http://books.google.com/books?id=_bMV8GPQW2gC}}
* {{Cite book|last=Hornblum|first=Allen M.|title=Acres of skin: human experiments at Holmesburg Prison : a story of abuse and exploitation in the name of medical science|publisher=Routledge|year=1998|isbn=9780415919906}}
* {{Cite book|last=Hornblum|first=Allen M.|title=Sentenced to Science: One Black Man's Story of Imprisonment in America|publisher=The Pennsylvania State University Press|year=2007|isbn=9780271033365}}
* {{Cite book|last=Lederer|first=Susan E.|title=Subjected to Science: Human Experimentation in America Before the Second World War|publisher=JHU Press |year=1997|isbn=9780801857096}}
* {{Cite book|last=Loue|first=Sana|title=Textbook of research ethics: theory and practice|publisher=Springer|year=2000|isbn=9780306464485}}
* {{Cite book|last=McCoy|first=Alfred W.|title=A question of torture: CIA interrogation, from the Cold War to the War on Terror|publisher=Metropolitan Books|year=2006|location=New York|isbn=978-0-8050-8041-4}}
* {{Cite book|last=Moreno|first=Jonathan D.|title=Undue Risk: Secret State Experiments on Humans|publisher=Routledge|year=2001|isbn=0415928354}}
* {{Cite book|last=Otterman|first=Michael|title=American torture: from the Cold War to Abu Ghraib and beyond|publisher=Melbourne Univ. Publishing|year=2007|isbn=9780522853339}}
* {{Cite book|title=Strangers at the Bedside: A History of How Law and Bioethics Transformed Medical Decision Making |author=David J. Rothman |publisher=Basic Books |year=1992 |isbn=9780465082100}}
* {{Cite book|last1=Shamoo|first1=Adil E.|last2=Resnik|first2=David B.|title=Responsible Conduct of Research|publisher=Oxford University Press US|year=2009|isbn=9780195368246}}
* {{Cite book|author=Washington, Harriet A.|title=Medical Apartheid: The Dark History of Medical Experimentation on Black Americans from Colonial Times to the Present|publisher=Random House|year=2008|isbn=9780767915472}}
</div>

==Further resources==
===General===
*{{cite book|title=The Birth of Bioethics|author=Albert R. Jonsen|publisher=Oxford University Press|year=1998|url=http://www.us.oup.com/us/catalog/general/subject/Medicine/Ethics/?view=usa&ci=9780195171471}}
*{{cite book|title=Ethics in Science and Medicine|author=Mark S. Frankel|volume=2|chapter=The Development of Policy Guidelines Governing Human Experimentation in the United States|year=1975}}
*{{Cite book|title= The abuse of man: an illustrated history of dubious medical experimentation|author=Wolfgang Weyers |publisher=Ardor Scribendi |year= 2003 |isbn=9781893357211}}
*[http://micahbooks.com/humanexperimentation33.html Human Experimentation: Before the Nazi Era and After], [[Roberta Kalechofsky]]

===Biological warfare and disease/pathogen experiments===
*[http://www.mtholyoke.edu/acad/intrel/chemical.htm Bibliography of Chemical and Biological Warfare documents]
*[http://www.raceandhistory.com/selfnews/viewnews.cgi?newsid1038118811,57464,.shtml The History of Bioterrorism in America], Richard Sanders, ''Race and History'', Sunday, November 24, 2002 (accessed: 02/18/2010)
*[http://www.fas.org/nuke/guide/usa/cbw/bw.htm Biological Weapons] – Federation of American Scientists
*Franz, et al., [http://www.bordeninstitute.army.mil/published_volumes/chembio/ch19.pdf The U.S. Biological Warfare and Biological Defense Programs]
*''US Army Activities in the US Biological Warfare Program'', 1977 Congressional report
*Christopher et al., "Biological warfare. A historical perspective", ''Journal of the American Medical Association''. 6 August 1997;278(5):412-7.
*[http://www.apfn.org/APFN/germs.htm Years Ago, The Military Sprayed Germs on U.S. Cities]", ''[[Wall Street Journal]]'', October 22, 2001, via American Patriot Friends Network, accessed November 13, 2008.

===Human radiation experiments===
====Books====
*''[[Harvey Wasserman#Killing Our Own (1982)|Killing Our Own: The disaster of America's experience with atomic radiation]]'', by Harvey Wasserman, Delacorte Press, c1992, ISBN 978-0440045670
*''[[The Plutonium Files|The Plutonium Files: America's Secret Medical Experiments]]'', by [[Eileen Welsome]], The Dial Press, 1999, ISBN 978-0385314022
*''[http://books.google.com/books?id=6kl4ynYiL3MC&printsec=frontcover&source=gbs_navlinks_s#v=onepage&q=&f=false The Treatment: The Story of Those Who Died in the Cincinnati Radiation Tests]'', by Martha Stephens, [[Duke University]] Press, c2002, Durham, N.C., ISBN 0-8223-2811-9
*''Bravo for the Marshallese: Regaining Control in a Post-Nuclear, Post-Colonial World'', by Holly M. Barker, Wadsworth, 2004. ISBN 0-534-61326-8

====Government documents====
*[http://www.gwu.edu/~nsarchiv/radiation/ Advisory Committee on Human Radiation Experiments (ACHRE)] – National Security Archives
*[http://books.google.com/books?id=X_LIVk92QtkC&dq=%22operation+plumbbob%22+OR+nevada+atmospheric+%22thyroid+cancer%22&client=firefox-a&source=gbs_navlinks_s Exposure of the American population to radioactive fallout from nuclear weapons tests: a review of the CDC-NCI draft report on a feasibility study of the health consequences to the American population from nuclear weapons tests conducted by the United States and other nations], ''National Research Council (U.S.). Committee to Review the CDC-NCI Feasibility Study of the Health Consequences from Nuclear Weapons Tests'', National Academies Press, 2003 ISBN 9780309087131

====Journals====
*"'A Little Touch of Buchenwald': America's Secret Radiation Experiments", ''Reviews in American History'' - Volume 28, Number 4, December 2000, pp.&nbsp;601–606
*[http://muse.jhu.edu/journals/kennedy_institute_of_ethics_journal/v006/6.3faden.html, Chair's Perspective on the Work of the Advisory Committee on Human Radiation Experiments] by [[Ruth Faden]]

===Psychological/torture/interrogation experiments===
*[http://ballistichelmet.org/school/kubark11.html Bibliography of U.S. interrogation/torture research]
*''Truth, torture, and the American way'', [[Jennifer Harbury]]
*Biderman, A. ''Social-Psychological Needs and "Involuntary" Behavior as Illustrated by Compliance in Interrogation'', Sociometry, Vol. 23, No. 2 (Jun., 1960), pp.&nbsp;120–147
*[http://www.time.com/time/magazine/article/0,9171,915244-1,00.html The CIA: Mind-Bending Disclosures] – ''Time Magazine'', Monday, Aug. 15, 1977 (accessed: 02/18/2010)
*[http://facstaff.gpc.edu/~shale/humanities/composition/assignments/experiment/lsd.html Resources on Drug Experimentation and Related Mind Control Experiments by the U.S. Government]

===Video===
*[http://www.youtube.com/watch?v=iflBkRlpRy0 MKULTRA Victim Testimony A] – 1977 MKULTRA Congressional Hearings
*[http://www.youtube.com/watch?v=eXDASDDrDkM MKULTRA Victim Testimony B] – 1977 MKULTRA Congressional Hearings
*[http://www.youtube.com/watch?v=F-ES8Bv0_8w MKULTRA Victim Testimony C] – 1977 MKULTRA Congressional Hearings
*[http://vimeo.com/21430782 President Clinton apologizes for Human Radiation Experiments]
*[http://www.hss.energy.gov/HealthSafety/ohre/roadmap/whitehouse/appa.html Complete transcript of Clinton's apology for Human Radiation Experiments]
* [http://www.democracynow.org/2010/6/8/experiments_in_torture_medical_group_accuses Physicians for Human Rights Accuses CIA of Carrying Out Illegal Human Experimentation] - video report by ''[[Democracy Now!]]''
*[http://www.democracynow.org/2010/10/5/the_dark_history_of_medical_experimentation The Dark History of Medical Experimentation from the Nazis to Tuskegee to Puerto Rico] - video report by ''[[Democracy Now!]]''

{{DEFAULTSORT:Human Experimentation In The United States}}
[[Category:Human rights abuses]]
[[Category:Medical research]]
[[Category:Human subject research in the United States| ]]

[[en:Unethical human experimentation in the United States ]]
[[ja:アメリカ合衆国における人体実験]]
[[vi:Thí nghiệm vô nhân đạo trên người tại Hoa Kỳ]]

2012年3月3日 (六) 11:18的版本

火炬木


在美國有不少被認為是不道德的人體實驗被實施,而且通常是在人体试验未被知曉、同意知情同意的情形下被實施。

這些實驗包括:故意讓人感染致命或使人虛弱的疾病、使人在生物化學武器中暴露、人體放射實驗、向人注射毒性放射性物質、外科實驗、酷刑/拷问實驗、涉及精神药品的實驗等等。一些實驗被實施於兒童、病人或精神病人,實驗經常被披上“藥物治療”的外衣。這些人中大部分是貧困少数族裔罪犯

很多實驗由美国政府,尤其是中央情报局美国军事和聯邦或軍隊公司提供資金。人類研究項目通常是高度保密的,直到研究的多年後才公開。

這些實驗的道德性、專業性和合法性問題與美國醫學和科學社群的牽連十分明顯,導致了甚多機構和政策試圖確保在未來的美國人體實驗道德和合法。公眾在發現人體實驗後強烈抗議,導致多次國會調查和聽證,包括Church CommitteeRockefeller CommissionAdvisory Committee on Human Radiation Experiments等。

外科實驗

1840年代間,常被稱作“妇科学之父”的J. Marion Sims, who is often referred to as "the father of 妇科学",在未麻醉的情況下給非洲婦女奴隸做實驗。其中一個的女人African被進行30次手術後死亡。[1]為了測試他一個關於破伤风成因的理論,Sims用鞋匠的锥子穿過女奴隸孩子的頭骨。[2][3]

In 1874, Mary Rafferty, an Irish servant woman, came to Dr. Roberts Bartholow of the Good Samaritan Hospital in Cincinnati for treatment of her cancer. Seeing a research opportunity, he cut open her head, and inserted needle electrodes into her exposed brain matter.[4] He described the experiment as follows:

When the needle entered the brain substance, she complained of acute pain in the neck. In order to develop more decided reactions, the strength of the current was increased ... her countenance exhibited great distress, and she began to cry. Very soon, the left hand was extended as if in the act of taking hold of some object in front of her; the arm presently was agitated with clonic spasm; her eyes became fixed, with pupils widely dilated; lips were blue, and she frothed at the mouth; her breathing became stertorous; she lost consciousness and was violently convulsed on the left side. The convulsion lasted five minutes, and was succeeded by a coma. She returned to consciousness in twenty minutes from the beginning of the attack, and complained of some weakness and vertigo.

——Dr. Bartholow's research report[4]

1896年,Dr. Arthur Wentworth在波士顿兒童醫院的29個年輕兒童身上實施了腰椎穿刺,沒有他們父母的知情。[5]

1913年到1951年間,San Quentin 監獄的總外科醫生Dr. Leo Stanley在監獄中數百個名囚犯身上進行了許多實驗。包括不少睾丸植入,在實驗中Stanley把死刑犯的睾丸拿出,移植到活囚犯的身上。他其他實驗中,他嘗試將家山羊野猪的睾丸移植到活囚犯身上。他還實施了多個优生学實驗,將San Quentin 犯人强迫绝育[6] Stanley認為這樣做可以使老人煥發青春、控制犯罪(他認為犯罪有生物原因)以及防止“不合適”的生育。[6][7]

病菌、疾病和生物戰藥劑

1880年代,在夏威夷一家醫院工作的一名加利福尼亞麻风病醫生讓12個12歲以下的年輕女孩感染了梅毒。[5]

1895年,作為實驗的一部分,紐約一位小儿科醫生故意給兩個“傻子”(精神殘疾男孩)—一人4歲,一人16歲—感染了淋病。縱觀十九世紀晚期到二十世紀早期,可以發現40多份在實驗中感染淋病的報告,包括淋病組織被加到生病兒童的眼睛中。[5][8][9]

1900年[查证请求],在菲律宾美国軍隊醫生將5名囚犯感染腺鼠疫,使29名囚犯感染诱发型脚气病;其中4人因此死亡。[10][11]1906年,Professor Richard Strong of Harvard University intentionally infected 24 Filipino prisoners with 霍乱, which had somehow become infected with plague. 他在沒有病人同意,也沒告知他們自己在做什麼的情況下進行實驗。所有對象生病,13人死亡。[11][12]

1908年,三名费城研究人員在St. Vincent's House孤兒院用结核菌素感染了幾十名兒童,導致了一些孩子的永久性失明和許多其他孩子痛苦的機能障礙和炎症。在研究中,他們把兒童說成是“应用材料”(material used)。[13]

1909年,F. C. Knowles發表了一項研究,描述了在孤兒院爆發Molluscum contagiosum後,他是如何故意將兩名為染病的孤兒感染上這種病的。[5]

1911年,洛克菲勒大学的Dr. 野口英世向146名醫院病人(包括兒童)注射了梅毒。之後野口英世被一些兒童患者的家長起訴,家長陳述梅毒是他實驗的結果。[14]

A subject of the Tuskegee syphilis experiment has his blood drawn, circa 1953

塔斯基吉梅毒试验[15]是由U.S. Public Health Service 1932年到1972年在塔斯基吉 (亚拉巴马州)之間做出的临床试验。實驗中,400名患有梅毒的貧困男性黑人被研究人員提供“治療”。病人被告知,他們被在被治療,但實際上沒有—儘管他們有青霉素,當時被知曉可治療致命疾病—研究人員想看到梅毒在人體上的影響。1972年研究結束時,只有74人存活。參與測試的399個人中28人死於梅毒,100人死於并发症,40個人的妻子被傳染,19人的孩子得了先天性梅毒。這項結束在1972年被洩密到媒體時,才因公眾的強烈反對而不得不結束。[16]

1941年,密歇根大学醫生Francis和乔纳斯·索尔克等研究人員故意給一些密歇根精神病院的病人感染流行性感冒病毒,通過向他們的鼻道噴灑該病毒。 virus by spraying the virus into their nasal .[17] Francis Rous, editor of the Journal of Experimental Medicine wrote the following to Francis regarding the experiments:

"It may save you much trouble if you publish your paper ... elsewhere than in the Journal of Experimental Medicine. The Journal is under constant scrutiny by the anti-vivisectionists who would not hesitate to play up the fact that you used for your tests human beings of a state institution. That the tests were wholly justified goes without saying."[18]

1941年, Dr. William C. Black inoculated a twelve month old baby "offered as a volunteer" with herpes. He submitted his research to The Journal of Experimental Medicine and it was rejected on ethical grounds. The editor of the Journal of Experimental Medicine, Francis Payton Rous, called the experiment "an abuse of power, an infringement of the rights of an individual, and not excusable because the illness which followed had implications for science."[19][20][21] It was later published in the Journal of Pediatrics.[22]

The Stateville Penitentiary Malaria Study was the site of a controlled study of the effects of malaria on the prisoners of Stateville Penitentiary near Joliet, Illinois beginning in the 1940s. The study was conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department. At the Nuremberg trials, Nazi doctors cited the malaria experiments as part of their defense.[23][24] The study continued at Stateville Penitentiary for 29 years. In related studies from 1944 to 1946, Dr. Alf Alving, a professor at the University of Chicago Medical School, purposely infected psychiatric patients at the Illinois State Hospital with malaria, so that he could test experimental malaria treatments on them.[25]

In a 1946 to 1948 study in Guatemala, U.S. researchers used prostitutes to infect prison inmates, insane asylum patients, and Guatemalan soldiers with syphilis and other sexually transmitted diseases, in order to test the effectiveness of penicillin in treating sexually transmitted diseases. They later tried infecting people with "direct inoculations made from syphilis bacteria poured into the men's penises and on forearms and faces that were slightly abraded . . . or in a few cases through spinal punctures". Approximately 700 people were infected as part of the study (including orphan children). The study was sponsored by the Public Health Service, the National Institutes of Health and the Pan American Health Sanitary Bureau (now the World Health Organization's Pan American Health Organization) and the Guatemalan government. The team was led by John Charles Cutler, who later participated in the Tuskegee syphilis experiments. Cutler chose to do the study in Guatemala because he would not have been permitted to do it in the United States.[26][27][28][29]

In 1950, in order to conduct a simulation of a biological warfare attack, the US Navy used airplanes to spray large quantities of the bacteria Serratia marcescens - considered harmless at this time - over the city of San Francisco, California, which caused numerous citizens to contract pneumonia-like illnesses, and killed at least one person.[30][31][32][33][34][35] The family of the man who was killed sued for gross negligence, but a federal judge ruled in favor of the government in 1981.[36] Serratia tests were continued until at least 1969.[37]

Also in 1950, Dr. Joseph Stokes of the University of Pennsylvania deliberately infected 200 female prisoners with viral hepatitis.[38]

From the 1950s to 1972, mentally disabled children at the Willowbrook State School in Staten Island, New York were intentionally infected with viral hepatitis, in research whose purpose was to help discover a vaccine.[39] From 1963 to 1966, Saul Krugman of New York University promised the parents of mentally disabled children that their children would be enrolled into Willowbrook in exchange for signing a consent form for procedures that he claimed were "vaccinations." In reality, the procedures involved deliberately infecting children with viral hepatitis by feeding them an extract made from the feces of patients infected with the disease.[40][41]

In 1952, Sloan-Kettering Institute researcher Chester M. Southam injected live cancer cells into prisoners at the Ohio State Prison. Half of the prisoners in this NIH-sponsored study were black - the other half weren't. Also at Sloan-Kettering, 300 healthy women were injected with live cancer cells without being told. The doctors stated that they knew at the time that it might cause cancer.[42]

In 1955, the CIA conducted a biological warfare experiment (despite the Fourth Geneva Convention) where they released whooping cough bacteria from boats outside of Tampa Bay, Florida, causing a whooping cough epidemic in the city, and killing at least 12 people.[43][44][45]

In 1956 and 1957, several U.S. Army biological warfare experiments were conducted on the cities of Savannah, Georgia and Avon Park, Florida. In the experiments, Army bio-warfare researchers released millions of infected mosquitoes on the two towns, in order to see if the insects could potentially spread yellow fever and dengue fever. Hundreds of residents contracted a wide array of illnesses, including fevers, respiratory problems, stillbirths, encephalitis, and typhoid. Army researchers pretended to be public health workers, so that they could photograph and perform medical tests on the victims. Several people died as a result of the experiments.[10][46]

In 1962, twenty-two elderly patients at the Jewish Chronic Disease Hospital in Brooklyn, New York were injected with live cancer cells by Chester M. Southam, who in 1952 had done the same to prisoners at the Ohio State Prison, in order to "discover the secret of how healthy bodies fight the invasion of malignant cells". The administration of the hospital attempted to cover the study up, but the New York State medical licensing board ultimately placed Southam on probation for one year. Two years later, the American Cancer Society elected him as their Vice President.[47]

In 1966, the U.S. Army released the harmless Bacillus globigii into the tunnels of the New York subway system as part of a field study called A Study of the Vulnerability of Subway Passengers in New York City to Covert Attack with Biological Agents.[43][48][49][50][51] The Chicago subway system was also subject to a similar experiment by the Army.[43]

Human radiation experiments

Researchers in the United States have performed thousands of human radiation experiments to determine the effects of atomic radiation and radioactive contamination on the human body, generally on people who were poor, sick, or powerless.[52] Most of these tests were performed, funded, or supervised by the United States military, Atomic Energy Commission, or various other US federal government agencies.

The experiments included a wide array of studies, involving things like feeding radioactive food to mentally disabled children or conscientious objectors, inserting radium rods into the noses of soldiers, deliberately releasing radioactive chemicals over U.S. and Canadian cities, measuring the health effects of radioactive fallout from nuclear bomb tests, injecting pregnant women and babies with radioactive chemicals, and irradiating the testicles of prison inmates, amongst other things.

Ultimately, public outcry over the experiments led to the 1994 Advisory Committee on Human Radiation Experiments.

Radioactive iodine experiments

In 1953, the U.S. Atomic Energy Commission (AEC) ran several studies on the health effects of radioactive iodine in newborns and pregnant women at the University of Iowa. In one study, researchers gave pregnant women from 100 to 200 microcuries of iodine-131, in order to study the women's aborted embryos in an attempt to discover at what stage, and to what extent, radioactive iodine crosses the placental barrier. In another study, they gave 25 newborn babies (who were under 36 hours old and weighed from 5.5 to 8.5 lbs) iodine-131, either by oral administration or through an injection, so that they could measure the amount of iodine in their thyroid glands.[53]

In another AEC study, researchers at the University of Nebraska College of Medicine fed iodine-131 to 28 healthy infants through a gastric tube to test the concentration of iodine in the infants' thyroid glands.[53]

In a 1949 operation called the "Green Run," the AEC released iodine-131 and xenon-133 to the atmosphere which contaminated an 500,000-英畝(2,000-平方公里) area containing three small towns near the Hanford site in Washington.[54]

In 1953, the AEC sponsored a study to discover if radioactive iodine affected premature babies differently from full-term babies. In the experiment, researchers from Harper Hospital in Detroit orally administered iodine-131 to 65 premature and full-term infants who weighed from 2.1 to 5.5磅(2.5公斤).[53]

In 1962, the Hanford site again released I-131, stationing test subjects along its path to record its effect on them. The AEC also recruited Hanford volunteers to ingest milk contaminated with I-131 during this time.[53]

Uranium experiments

Between 1946 and 1947, researchers at the University of Rochester injected uranium-234 and uranium-235 in dosages ranging from 6.4 to 70.7 micrograms per kilogram of body weight into six people to study how much uranium their kidneys could tolerate before becoming damaged.[55]

Between 1953 and 1957, at the Massachusetts General Hospital, Dr. William Sweet injected eleven terminally ill, comatose and semi-comatose patients with uranium in an experiment to determine, among other things, its viability as a chemotherapy treatment against brain tumors, which all but one of the patients had (one being a mis-diagnosis). Dr. Sweet, who died in 2001, maintained that consent had been obtained from the patients and next of kin.[56][57]

Plutonium experiments

In 1945, as part of the Manhattan Project, three patients at Billings Hospital at the University of Chicago were injected with plutonium.[58]

In 1946, six employees of a Chicago metallurgical lab were given water that was contaminated with plutonium-239, so that researchers could study how plutonium is absorbed into the digestive tract.[55]

Experiments involving other radioactive materials

Immediately after World War II, researchers at Vanderbilt University gave 829 pregnant mothers in Tennessee what they were told were "vitamin drinks" that would improve the health of their babies, but were, in fact, mixtures containing radioactive iron, to determine how fast the radioisotope crossed into the placenta. At least three children are known to have died from the experiments, from cancers and leukemias.[59][60] Four of the women's babies died from cancers as a result of the experiments, and the women experienced rashes, bruises, anemia, hair/tooth loss, and cancer.[52]

From 1946 to 1953, at the Walter E. Fernald State School in Massachusetts, in an experiment sponsored by the U.S. Atomic Energy Commission and the Quaker Oats corporation, 73 mentally disabled children were fed oatmeal containing radioactive calcium and other radioisotopes, in order to track "how nutrients were digested". The children were not told that they were being fed radioactive chemicals and were told by hospital staff and researchers that they were joining a "science club".[59][61][62][63]

In the 1950s, researchers at the Medical College of Virginia performed experiments on severe burn victims, most of them poor and black, without their knowledge or consent, with funding from the Army and in collaboration with the AEC. In the experiments, the subjects were exposed to additional burning, experimental antibiotic treatment, and injections of radioactive isotopes. The amount of radioactive phosphorus-32 injected into some of the patients, 500 microcuries, was 50 times the "acceptable" dose for a healthy individual; for people with severe burns, this likely led to significantly increased death rates.[64][65]

Between 1948 and 1954, funded by the federal government, researchers at the Johns Hopkins Hospital inserted radium rods into the noses of 582 Baltimore, Maryland schoolchildren as an alternative to adenoidectomy.[66][67][68] Similar experiments were performed on over 7,000 U.S. Army and Navy personnel during World War II.[66] It went on to become a standard medical treatment and was used in over two and a half million Americans.[66]

In another study at the Walter E. Fernald State School, in 1956, researchers gave mentally disabled children radioactive calcium orally and intravenously. They also injected radioactive chemicals into malnourished babies and then pushed needles through their skulls, into their brains, through their necks, and into their spines to collect cerebrospinal fluid for analysis.[63][69]

An eighteen-year-old woman at an upstate New York hospital, expecting to be treated for a pituitary gland disorder, was injected with plutonium.[70]

In 1961 and 1962, ten Utah State Prison inmates had blood samples taken which were then mixed with radioactive chemicals and reinjected back into their bodies.[71]

In a 1967 study that was published in the Journal of Clinical Investigation, pregnant women were injected with radioactive cortisol to see if it would cross the placental barrier and affect the fetuses.[72]

Fallout research

Cover of the final report of Project 4.1, which examined the effects of radioactive fallout on the natives of the Marshall Islands

In 1954, American scientists conducted fallout exposure research on the citizens of the Marshall Islands after they were inadvertently irradiated[73] by the Castle Bravo nuclear test in Project 4.1. The Bravo test was detonated upwind of Rongelap Atoll and the residents were exposed to serious radiation levels, up to 180 rads. Of the 236 Marshallese exposed, some developed severe radiation sickness and one died, and long term effects included birth defects, "jellyfish" babies, and thyroid problems.[74]

In 1957, atmospheric nuclear explosions in Nevada, which were part of Operation Plumbbob were later determined to have released enough radiation to have caused from 11,000 to 212,000 excess cases of thyroid cancer amongst U.S. citizens who were exposed to fallout from the explosions, leading to between 1,100 and 21,000 deaths.[75]

Early in the Cold War, in studies known as Project GABRIEL and Project SUNSHINE, researchers in the United States, the United Kingdom, and Australia attempted to determine just how much nuclear fallout would be required to make the Earth uninhabitable.[76][77] They realized that atmospheric nuclear testing had provided them an opportunity to investigate this. Such tests had dispersed radioactive contamination worldwide, and examination of human bodies could reveal how readily it was taken up and hence how much damage it caused. Of particular interest was strontium-90 in the bones. Infants were the primary focus, as they would have had a full opportunity to absorb the new contaminants.[78]

As a result of this conclusion, researchers began a program to collect human bodies and bones from all over the world, with a particular focus on infants. The bones were cremated and the ashes analyzed for radioisotopes. This project was kept secret primarily because it would be a public relations disaster; as a result parents and family were not told what was being done with the body parts of their relatives.[79]

Irradiation experiments

Between 1960 and 1971, the Department of Defense funded non-consensual whole body radiation experiments on poor, black cancer patients, who were not told what was being done to them. Patients were told that they were receiving a "treatment" that might cure their cancer, but in reality the Pentagon was attempting to determine the effects of high levels of radiation on the human body. One of the doctors involved in the experiments, Robert Stone, was worried about litigation by the patients, so he only referred to them by their initials on the medical reports. He did this so that, in his words, "there will be no means by which the patients can ever connect themselves up with the report", in order to prevent "either adverse publicity or litigation".[80]

From 1960 to 1971, Dr. Eugene Saenger, funded by the Defense Atomic Support Agency, performed whole body radiation experiments on more than 90 poor, black, terminally ill cancer patients with inoperable tumors at the University of Cincinnati Medical Center. He forged consent forms, and did not inform them of the risks of irradiation. The patients were given 100 or more rads of whole-body radiation, which in many caused intense pain and vomiting. Critics have questioned the medical rationale for this study, and contend that the main purpose of the research was to study the acute effects of radiation exposure.[81][82]

From 1963 to 1973, a leading endocrinologist, Dr. Carl Heller, irradiated the testicles of Oregon and Washington prisoners. In return for their participation, he gave them $5 a month, and $100 when they had to receive a vasectomy upon conclusion of the trial. The surgeon who sterilized the men said that it was necessary to "keep from contaminating the general population with radiation-induced mutants". One of the researchers who had worked with Heller on the experiments, Dr. Joseph Hamilton, said that the experiments "had a little of the Buchenwald touch".[83]

In 1963, University of Washington researchers irradiated the testes of 232 prisoners to determine the effects of radiation on testicular function. When these inmates later left prison and had children, at least four of them had offspring born with birth defects. The exact number is unknown because researchers never followed up on the status of the subjects.[84]

Chemical experiments

From 1942 to 1944, the U.S. Chemical Warfare Service conducted experiments which exposed thousands of U.S. military personnel to mustard gas, in order to test the effectiveness of gas masks and protective clothing.[85][86][87][88]

From 1950 through 1953, the US Army sprayed toxic chemicals over six cities in the United States and Canada, in order to test dispersal patterns of chemical weapons. Army records stated that the chemicals which were sprayed on the city of Winnipeg, Canada, included zinc cadmium sulfide.[89]

To test whether or not sulfuric acid, which is used in making molasses, was harmful as a food additive, the Louisiana State Board of Health commissioned a study to feed "Negro prisoners" nothing but molasses for five weeks. One report stated that prisoners didn't "object to submitting themselves to the test, because it would not do any good if they did".[12]

A 1953 article in the medical/scientific journal Clinical Science[90] described a medical experiment in which researchers intentionally blistered the skin on the abdomens of 41 children, who ranged in age from 8 to 14, using cantharide. The study was performed to determine how severely the substance injures/irritates the skin of children. After the studies, the children's blistered skin was removed with scissors and swabbed with peroxide.[72]

Chloracne resulting from exposure to dioxins, such as those that Albert Kligman injected into prisoners at the Holmesburg Prison

From approximately 1951 to 1974, the Holmesburg State Prison in Pennsylvania was the site of extensive dermatological research operations, using prisoners as subjects. Led by Dr. Albert M. Kligman of the University of Pennsylvania, the studies were performed on behalf of Dow Chemical Company, the U.S. Army, and Johnson & Johnson.[91][92][93] In one of the studies, for which Dow Chemical paid Kligman $10,000, Kligman injected dioxin—a highly toxic, carcinogenic component of Agent Orange, which Dow was manufacturing for use in Vietnam at the time—into 70 prisoners (most of them black). The prisoners developed severe lesions which went untreated for seven months.[10] Dow Chemical wanted to study the health effects of dioxin and other herbicides, and how they affect human skin, because workers at their chemical plants were developing chloracne. In the study, Kligman applied roughly the amount of dioxin Dow employees were being exposed to. In 1980 and 1981, some of the people who were used in this study sued Professor Kligman for a variety of health problems, including lupus and psychological damage.[94]

Kligman later continued his dioxin studies, increasing the dosage of dioxin he applied to 10 prisoners' skin to 7,500 micrograms of dioxin, which is 468 times the dosage that the Dow Chemical official Gerald K. Rowe had authorized him to administer. As a result, the prisoners developed inflammatory pustules and papules.[94]

The Holmesburg program also paid hundreds of inmates a nominal stipend to test a wide range of cosmetic products and chemical compounds, whose health effects were unknown at the time.[95][96] Upon his arrival at Holmesberg, Kligman is claimed to have said "All I saw before me were acres of skin ... It was like a farmer seeing a fertile field for the first time".[97] It was reported in a 1964 issue of Medical News that 9 out of 10 prisoners at Holmesburg Prison were medical test subjects.[98]

In 1967, the U.S. Army paid Kligman to apply skin-blistering chemicals to the faces and backs of inmates at Holmesburg to, in Kligman's words, "learn how the skin protects itself against chronic assault from toxic chemicals, the so-called hardening process."[94]

Psychological and torture experiments

U.S. government research

The United States government funded and performed numerous psychological experiments, especially during the Cold War era. Many of these experiments were performed to help develop more effective torture and interrogation techniques for the U.S. military and intelligence agencies, and to develop techniques for resisting torture at the hands of enemy nations and organizations.

In studies running from 1947 to 1953, which were known as Project Chatter, the U.S. Navy began identifying and testing truth serums, which they hoped could be used during interrogations of Soviet spies. Some of the chemicals tested on human subjects included mescaline and the anticholinergic drug scopolamine.[99]

Shortly thereafter, in 1950, the CIA initiated Project Bluebird, later renamed Project Artichoke, whose stated purpose was to develop "the means to control individuals through special interrogation techniques", "way[s] to prevent the extraction of information from CIA agents", and "offensive uses of unconventional techniques, such as hypnosis and drugs".[99][100][101] The purpose of the project was outlined in a memo dated January 1952 that stated, "Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature, such as self preservation?" The project studied the use of hypnosis, forced morphine addiction and subsequent forced withdrawal, and the use of other chemicals, among other methods, to produce amnesia and other vulnerable states in subjects.[102][103][104][105][106] In order to "perfect techniques for the abstraction of information from individuals, whether willing or not", Project Bluebird researchers experimented with a wide variety of psychoactive substances, including LSD, heroin, marijuana, cocaine, PCP, mescaline, and ether.[107] Project Bluebird researchers dosed over 7,000 U.S. military personnel with LSD, without their knowledge or consent, at the Edgewood Arsenal in Maryland. More than 1,000 of these soldiers suffered from several psychiatric illnesses, including depression and epilepsy, as a result of the tests. Many of them tried to commit suicide.[108]

In 1952, professional tennis player Harold Blauer died when injected with a fatal dose of a mescaline derivative at the New York State Psychiatric Institute of Columbia University, by Dr. James Cattell. The United States Department of Defense, which sponsored the injection, worked in collusion with the Department of Justice, and the New York State Attorney General to conceal evidence of its involvement for 23 years. Cattell claimed that he did not know what the army had given him to inject into Blauer, saying: "We didn't know whether it was dog piss or what we were giving him."[109][110]

In 1953, the CIA placed several of its interrogation and mind-control programs under the direction of a single program, known by the code name MKULTRA, after CIA director Allen Dulles complained about not having enough "human guinea pigs to try these extraordinary techniques".[111] The MKULTRA project was under the direct command of Dr. Sidney Gottlieb of the Technical Services Division.[111] The project received over $25 million, and involved hundreds of experiments on human subjects at eighty different institutions.

In a memo describing the purpose of one MKULTRA program subprogram, Richard Helms said:

We intend to investigate the development of a chemical material which causes a reversible, nontoxic aberrant mental state, the specific nature of which can be reasonably well predicted for each individual. This material could potentially aid in discrediting individuals, eliciting information, and implanting suggestions and other forms of mental control.

——Richard Helms, internal CIA memo[112]

In 1954, the CIA's Project QKHILLTOP was created to study Chinese brainwashing techniques, and to develop effective methods of interrogation. Most of the early studies are believed to have been performed by the Cornell University Medical School's human ecology study programs, under the direction of Dr. Harold Wolff.[99][113][114] Wolff requested that the CIA provide him any information they could find regarding "threats, coercion, imprisonment, deprivation, humiliation, torture, 'brainwashing', 'black psychiatry', and hypnosis, or any combination of these, with or without chemical agents". According to Wolff, the research team would then:

...assemble, collate, analyze and assimilate this information and will then undertake experimental investigations designed to develop new techniques of offensive/defensive intelligence use ... Potentially useful secret drugs (and various brain damaging procedures) will be similarly tested in order to ascertain the fundamental effect upon human brain function and upon the subject's mood ... Where any of the studies involve potential harm of the subject, we expect the Agency to make available suitable subjects and a proper place for the performance of the necessary experiments.

——Dr. Harold Wolff, Cornell University Medical School[114]
... it was fun, fun, fun. Where else could a red-blooded American boy lie, kill, cheat, steal, rape and pillage with the sanction and bidding of the All-highest?
George Hunter White, who oversaw drug experiments for the CIA as part of Operation Midnight Climax[115]

Another of the MKULTRA subprojects, Operation Midnight Climax, consisted of a web of CIA-run safehouses in San Francisco, Marin, and New York which were established in order to study the effects of LSD on unconsenting individuals. Prostitutes on the CIA payroll were instructed to lure clients back to the safehouses, where they were surreptitiously plied with a wide range of substances, including LSD, and monitored behind one-way glass. Several significant operational techniques were developed in this theater, including extensive research into sexual blackmail, surveillance technology, and the possible use of mind-altering drugs in field operations.[115]

In 1957, with funding from a CIA front organization, Dr. Ewan Cameron of the Allan Memorial Institute in Montreal, Canada began MKULTRA Subproject 68.[116] His experiments were designed to first "depattern" individuals, erasing their minds and memories—reducing them to the mental level of an infant—and then to "rebuild" their personality in a manner of his choosing.[117] To achieve this, Cameron placed patients under his "care" into drug-induced comas for up to 88 days, and applied numerous high voltage electric shocks to them over the course of weeks or months, often administering up to 360 shocks per person. He would then perform what he called "psychic driving" experiments on the subjects, where he would repetitively play recorded statements, such as "You are a good wife and mother and people enjoy your company", through speakers he had implanted into blacked-out football helmets that he bound to the heads of the test subjects (for sensory deprivation purposes). The patients could do nothing but listen to these messages, played for 16–20 hours a day, for weeks at a time. In one case, Cameron forced a person to listen to a message non-stop for 101 days.[117] Using CIA funding, Cameron converted the horse stables behind Allen Memorial into an elaborate isolation and sensory deprivation chamber which he kept patients locked in for weeks at a time.[117] Cameron also induced insulin comas in his subjects by giving them large injections of insulin, twice a day for up to two months at a time.[99] Several of the children who Cameron experimented on were sexually abused, in at least one case by several men. One of the children was filmed numerous times performing sexual acts with high-ranking federal government officials, in a scheme set up by Cameron and other MKULTRA researchers, to blackmail the officials to ensure further funding for the experiments.[118]

The frequent screams of the patients that echoed through the hospital did not deter Cameron or most of his associates in their attempts to depattern their subjects completely
John D. Marks, The Search for the Manchurian Candidate, Chapter 8[119]

The CIA leadership had serious concerns about their unethical and illegal behavior, as evidenced in a 1957 Inspector General Report, which stated:

Precautions must be taken not only to protect operations from exposure to enemy forces but also to conceal these activities from the American public in general. The knowledge that the agency is engaging in unethical and illicit activities would have serious repurcussions in political and diplomatic circles ...

——1957 CIA Inspector General Report[120]

In 1957, Dr. Robert Heath of Tulane University performed experiments on schizophrenic patients, which were funded by the U.S. Army. In the studies, he dosed them with high levels of LSD, and then implanted "deep electrodes" in their brains to take EEG readings.[121]

MKULTRA activities continued until 1973 when CIA director Richard Helms, fearing that they would be exposed to the public, ordered the project terminated, and all of the files destroyed.[111] However, a clerical error had sent many of the documents to the wrong office, so when CIA workers were destroying the files, some of them remained, and were later released under a Freedom of Information Act request by investigative journalist John Marks. Many people in the American public were outraged when they learned of the experiments, and several congressional investigations took place including the Church Committee and the Rockefeller Commission.

On 26 April 1976, the Church Committee of the United States Senate issued a report, "Final Report of the Select Committee to Study Governmental Operation with Respect to Intelligence Activities",[122] In Book I, Chapter XVII, p 389 this report states:

LSD was one the materials tested in the MKULTRA program. The final phase of LSD testing involved surreptitious administration to unwitting non-volunteer subjects in normal life settings by undercover officers of the Bureau of Narcotics acting for the CIA.
A special procedure, designated MKDELTA, was established to govern the use of MKULTRA materials abroad. Such materials were used on a number of occasions. Because MKULTRA records were destroyed, it is impossible to reconstruct the operational use of MKULTRA materials by the CIA overseas; it has been determined that the use of these materials abroad began in 1953, and possibly as early as 1950.[123][124][125][126][127]
Drugs were used primarily as an aid to interrogations, but MKULTRA/MKDELTA materials were also used for harassment, discrediting, or disabling purposes.[123][124][125][126][127]

In 1963, CIA had synthesized many of the findings from its psychological research into what became known as the KUBARK Counterintelligence Interrogation handbook,[128] which cited the MKULTRA studies, and other secret research programs as the scientific basis for their interrogation methods[117] Cameron regularly traveled around the U.S. teaching military personnel about his techniques (hooding of prisoners for sensory deprivation, prolonged isolation, humiliation, etc.), and how they could be used in interrogations. Latin American paramilitary groups working for the CIA and U.S. military received training in these psychological techniques at places like the School of the Americas, and even today, many of the torture techniques developed in the MKULTRA studies and other programs are being used at U.S. military and CIA prisons such as Guantanamo Bay and Abu Ghraib.[117][129] In the aftermath of the Congressional hearings, major news media mainly focused on sensationalistic stories related to LSD, "mind-control", and "brainwashing", and rarely used the word "torture". This put off the image that CIA researchers were, as one author put it "a bunch of bumbling sci-fi buffoons", rather than a rational group of men who had run torture laboratories and medical experiments in major U.S. universities, and who had tortured, raped, and psychologically abused young children, driving many of them permanently insane.[117]

From 1964 to 1968, the U.S. Army paid $386,486 to professors Albert Kligman and Herbert W. Copelan to perform experiments with mind-altering drugs on 320 inmates of Holmesburg Prison. The goal of the study was to determine the minimum effective dose of each drug needed to disable 50 percent of any given population. Kligman and Copelan initially claimed that they were unaware of any long-term health effects the drugs could have on prisoners, however, documents later revealed that this was not the case.[94]

Medical professionals gathered and collected data on the CIA’s use of torture techniques on detainees, in order to refine those techniques, and to "to provide legal cover for torture, as well as to help justify and shape future procedures and policies", according to a report by Physicians for Human Rights. The report stated that: “Research and medical experimentation on detainees was used to measure the effects of large-volume waterboarding and adjust the procedure according to the results.” As a result of the waterboarding experiments, doctors recommended adding saline to the water “to prevent putting detainees in a coma or killing them through over-ingestion of large amounts of plain water.” Sleep deprivation tests were performed on over a dozen prisoners, in 48-, 96- and 180-hour increments. Doctors also collected data intended to help them judge the emotional and physical impact of the techniques so as to “calibrate the level of pain experienced by detainees during interrogation" and to determine if using certain types of techniques would increase a subject's "susceptibility to severe pain.". The CIA denied the allegations, claiming they never performed any experiments, and saying "The report is just wrong"; however, the U.S. government never investigated the claims.[130][131][132][133][134][135]

In August 2010, the U.S. weapons manufacturer Raytheon announced that it had partnered with a jail in Castaic, California in order to use prisoners as test subjects for a new non-lethal weapon system that "fires an invisible heat beam capable of causing unbearable pain."[136]

Academic research

In 1939, at the Iowa Soldiers' Orphans' Home in Davenport, Iowa, twenty-two children were the subjects of the so-called "monster" experiment. This experiment attempted to use psychological abuse to induce children who spoke normally to stutter. The experiment was designed by Dr. Wendell Johnson, one of the nation's most prominent speech pathologists, for the purpose of testing one of his theories on the cause of stuttering.[137]

In 1961, in response to the Nuremberg Trials, the Yale psychologist Stanley Milgram performed his study "Obedience to Authority Study", also known as the Milgram Experiment, in order to determine if it was possible that the Nazi genocide could have resulted from millions of people who were "just following orders". The Milgram Experiment raised questions about the ethics of scientific experimentation because of the extreme emotional stress suffered by the participants, who were told, as part of the experiment, to apply electric shocks to test subjects (who were actually actors not really receiving electric shocks).

Pharmacological research

At Harvard University, in the late 1940s, researchers began performing experiments where they tested diethylstilbestrol, a synthetic estrogen, on pregnant women at the Lying-In Hospital of the University of Chicago. The women experienced an abnormally high number of miscarriages and babies with low birth weight. None of the women were told that they were being experimented on.[138]

Researchers at the Laurel Children's Center in Maryland tested experimental acne medications on children, and continued their tests even after half of the children developed severe liver damage from the medications.[72]

From 1988 to 2008, the number of overseas clinical trials for drugs intended for American consumption increased by 2,000%, to approximately 6,500 trials. These trials are often conducted in areas with large numbers of poor and illiterate people who grant their consent by signing an "X" or making a thumb print on a form. These tests are rarely monitored by the FDA, and have in some cases proved deadly, such as a case where 49 babies died in New Delhi, India during a 30-month trial. The cost of testing in countries without safety regulations is much lower; and, due to lax or nonexistent oversight, pharmaceutical corporations (or research companies they've contracted out to) are able to more easily suppress research that demonstrates harmful effects and only report positive results.[139][140]

Other experiments

The 1846 journals of Dr. Walter F. Jones of Petersburg, Virginia describe how he poured boiling water onto the backs of naked slaves afflicted with typhoid pneumonia, at four-hour intervals, because he thought that this might "cure" the disease by "stimulating the capillaries".[141][142][143]

From early 1940 until 1953, Dr. Lauretta Bender, a highly respected pediatric neuropsychiatrist who practiced at Bellevue Hospital in New York City, performed electroshock experiments on at least 100 children. The children's ages ranged from 3–12 years. Some reports indicate that she may have performed such experiments on more than 200. Electroconvulsive treatment was used on more than 500 children at Bellevue Hospital from 1942 to 1956, including Bender's experiments, and then at Creedmoor State Hospital Children's Service from 1956 to 1969. Publicly, Bender claimed that the results of the "therapy" were positive, but in private memos, she expressed frustration over mental health issues caused by the treatments.[144] Bender would sometimes shock schizophrenic children (some less than 3 years old) twice per day, for 20 consecutive days. Several of the children became violent and suicidal as a result of the treatments.[145]

At Willowbrook State School for the mentally retarded in Staten Island, NY, a hightly controversial medical study was carried out there between 1963 and 1966 by medical researchers Saul Krugman and Robert W. McCollum. Healthy children who were mentally retarded, were secretly intentionally inoculated, orally and by injection, with a virus that causes the hepatitis, then monitored to gauge the effects of gamma globulin in combating the resultant disease.[3] A public outcry forced the study to be discontinued after it was exposed and condemnend by Senator Robert F. Kennedy. [146] New York Senator Robert Kennedy and a television crew visit Willowbrook State school in Staten Island NY. "He likens the conditions at Willowbrook to that of a “snake pit,” and states that the residents of these institutions were “denied access to education and are deprived of their civil liberties.” Later that same year, he addressed a joint session of the NYS Legislature on the “dehumanizing conditions” of the State’s institutions.[147]

In 1942, the Harvard University biochemist Edward Cohn injected 64 Massachusetts prisoners with cow blood, as part of an experiment sponsored by the U.S. Navy.[148][149][150]

In 1950, researchers at the Cleveland City Hospital ran experiments to study changes in cerebral blood flow where they injected people with spinal anesthesia, and inserted needles into their jugular veins and brachial arteries to extract large quantities of blood, and after massive blood loss which caused paralysis and fainting, measured their blood pressure. The experiment was often performed multiple times on the same subject.[72]

In a series of studies which were published in the medical journal Pediatrics, researchers from the University of California Department of Pediatrics performed experiments on 113 newborns ranging in age from 1 hour to 3 days, where they studied changes in blood pressure and blood flow. In one of the studies, researchers forced a catheter through the babies' umbilical arteries and into their aortas, and then submerged their feet in ice water. In another of the studies, they strapped 50 newborn babies to a circumcision board, and then turned them upside down so that all of their blood rushed into their heads.[72]

From 1963 to 1969 as part of Project Shipboard Hazard and Defense (SHAD), the U.S. Army performed tests which involved spraying several U.S. ships with various biological and chemical warfare agents, while thousands of U.S. military personnel were aboard the ships. The personnel were not notified of the tests, and were not given any protective clothing. Chemicals tested on the U.S. military personnel included the nerve gases VX and Sarin, toxic chemicals such as zinc cadmium sulfide and sulfur dioxide, and a variety of biological agents.[151]

The San Antonio Contraceptive Study was a clinical research study about the side effects of oral contraceptives published in 1971. Women came to a clinic in San Antonio for preventing pregnancies and were not told they were participating in a research study or receiving placebos. 10 of the women became pregnant while on placebos.[152][153][154]

In the 2000s, artificial blood was transfused into research subjects across the United States without their consent by Northfield Labs.[155] Later studies showed the artificial blood caused a significant increase in the risk of heart attacks and death.[156]

Legal, academic and professional policy

During the Nuremberg trials, several of the Nazi doctors and scientists who were being tried for their human experiments claimed that the inspiration for their studies had come from studies that they had seen performed in the United States.[10][47] In 1945, as part of Operation Paperclip, the United States government recruited 1,600 Nazi scientists, many of whom had performed horrific human experimentation in Nazi concentration camps. The scientists were offered immunity from any war crimes they had committed during the course of their work for the Nazi government, in return for doing research for the United States government. Many of the Nazi scientists continued their human experimentation when they arrived in the United States.[157]

A secret AEC document dated April 17, 1947, titled Medical Experiments in Humans stated: "It is desired that no document be released which refers to experiments with humans that might have an adverse reaction on public opinion or result in legal suits. Documents covering such fieldwork should be classified Secret."[53]

At the same time, the Public Health Service was instructed to tell citizens downwind from bomb tests that the increases in cancers were due to neurosis, and that women with radiation sickness, hair loss, and burned skin were suffering from "housewife syndrome".[53]

In 1964, the World Medical Association passed the Declaration of Helsinki, a set of ethical principles for the medical community regarding human experimentation.

In 1966, the National Institutes of Health (NIH) Office for Protection of Research Subjects (OPRR) was created, and issued its Policies for the Protection of Human Subjects which recommended establishing independent review bodies, which were later called institutional review boards.

In 1969, Kentucky Court of Appeals Judge Samuel Steinfeld dissented in Strunk v. Strunk, 445 S.W.2d 145, and made the first judicial suggestion that the Nuremberg Code should be applied to American jurisprudence.

In 1974 the National Research Act established the National Commission for the Protection of Human Subjects, and mandated that the Public Health Service to come up with regulations that would protect the rights of human research subjects.

Project MK-ULTRA was first brought to wide public attention in 1975 by the U.S. Congress, through investigations by the Church Committee, and by a presidential commission known as the Rockefeller Commission.[158][159]

In 1975, the Department of Health, Education and Welfare (DHEW) created regulation which included the recommendations laid out in the NIH's 1966 Policies for the Protection of Human Subjects. Title 45 of the Code of Federal Regulations, known as "The Common Rule," requires the appointment and utilization of institutional review boards (IRBs) in experiments using human subjects.

On April 18, 1979, prompted by an investigative journalist's public disclosure of the Tuskegee syphilis experiments, the United States Department of Health, Education, and Welfare (later renamed to Health and Human Services) released a report entitled "Ethical Principles and Guidelines for the Protection of Human Subjects of Research," authored by Dan Harms, which laid out many modern guidelines for ethical medical research.

In 1987 the United States Supreme Court ruled in United States v. Stanley, 483 U.S. 669, that a U.S. serviceman who was given LSD without his consent, as part of military experiments, could not sue the U.S. Army for damages.

Dissenting the verdict in U.S. v. Stanley, Justice Sandra Day O'Connor stated:

No judicially crafted rule should insulate from liability the involuntary and unknowing human experimentation alleged to have occurred in this case. Indeed, as Justice Brennan observes, the United States played an instrumental role in the criminal prosecution of Nazi officials who experimented with human subjects during the Second World War, and the standards that the Nuremberg Military Tribunals developed to judge the behavior of the defendants stated that the 'voluntary consent of the human subject is absolutely essential ... to satisfy moral, ethical, and legal concepts.' If this principle is violated, the very least that society can do is to see that the victims are compensated, as best they can be, by the perpetrators.

On January 15, 1994, President Bill Clinton formed the Advisory Committee on Human Radiation Experiments (ACHRE). This committee was created to investigate and report the use of human beings as test subjects in experiments involving the effects of ionizing radiation in federally funded research. The committee attempted to determine the causes of the experiments, and reasons why the proper oversight did not exist, and made several recommendations to help prevent future occurrences of similar events.[160]

As of 2007, not a single U.S. government researcher had been prosecuted for human experimentation, and many of the victims of U.S. government experiments have not received compensation, or in many cases, acknowledgment of what was done to them.[161]

See also

References

Notes

  1. ^ Some defend 'father of gynecology' by Barron H. Lerner, The Tuscaloosa News, Oct 30, 2003 (accessed: 02/17/2010)
  2. ^ Washington, 2008: pp. 62-63
  3. ^ Cina & Perper, 2010: p. 88
  4. ^ 4.0 4.1 Lederer, 1997: pp. 7-8
  5. ^ 5.0 5.1 5.2 5.3 Grodin & Glantz, 1994: pp. 7-11
  6. ^ 6.0 6.1 The Strange Career of Leo Stanley: Remaking Manhood and Medicine at San Quentin State Penitentiary, 1913–1951, Ethan Blue‌, Pacific Historical Review, May 2009, Vol. 78, No. 2, pp. 210–241, DOI 10.1525/phr.2009.78.2.210
  7. ^ Hornblum, 1998: p. 79
  8. ^ Lederer, 1997: p. 3
  9. ^ Shamoo & Resnick, 2009: pp. 238-239
  10. ^ 10.0 10.1 10.2 10.3 Germ War: The US RecordAlexander Cockburn, Counterpunch
  11. ^ 11.0 11.1 Cina & Perper, 2010: p. 89
  12. ^ 12.0 12.1 Hornblum, 1998: pp. 76-77 引用错误:带有name属性“acres-skin-76-77”的<ref>标签用不同内容定义了多次
  13. ^ Roger Cooter. In the Name of the Child. Routledge. 1992: 104–105. ISBN 9780203412237. 
  14. ^ Reviews and Notes: History of Medicine: Subjected to Science: Human Experimentation in America before the Second World War, Annals of Internal Medicine, American College of Physicians, July 15, 1995 vol. 123 no. 2 159
  15. ^ Tuskegee Study - Timeline. NCHHSTP. CDC. 2008-06-25 [2008-12-04]. 
  16. ^ The Tuskegee Syphilis Experiment Borgna Brunner. Retrieved 2010-03-25
  17. ^ Meiklejohn, Gordon N., M.D. "Commission on Influenza." in Histories' of the Commissions Ed. Theodore E. Woodward, M.D., The Armed Forced Epidemiological Board, 1994
  18. ^ Halpern, 2006: p. 199
  19. ^ Grodin & Glantz, 1994: p. 14
  20. ^ Brody, 1998: p. 120
  21. ^ Cina & Perper, 2010: p. 94
  22. ^ Black WC. The etiology of acute infectious gingivostomatitis (Vincent's stomatitis). The Journal of Pediatrics. 1942, 20 (2): 145–60. doi:10.1016/S0022-3476(42)80125-0.  已忽略未知参数|month=(建议使用|date=) (帮助)
  23. ^ George Annas & Michael Grodin, 1995: p. 267
  24. ^ Hornblum, 1999: p. 76
  25. ^ Rothman, 1992: p.36
  26. ^ U.S. sorry for Guatemala syphilis experiment. CBC News. October 1, 2010. 
  27. ^ Rob Stein. U.S. apologizes for newly revealed syphilis experiments done in Guatemala. Washington Post. October 1, 2010. 
  28. ^ US sorry over deliberate sex infections in Guatemala. BBC News. October 1, 2010. 
  29. ^ Chris McGreal. US says sorry for 'outrageous and abhorrent' Guatemalan syphilis tests. Guardian (London). October 1, 2010. 
  30. ^ Moreno, 2001: pp. 233-234
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  32. ^ "How the U.S. Government Exposed Thousands of Americans to Lethal Bacteria to Test Biological Warfare", Democracy Now!, 7/13/2005
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  35. ^ Anía BJ. Serratia: Overview. eMedicine. WebMD. October 1, 2008.  Retrieved on November 23, 2011.
  36. ^ Cole, 1996: p. 17
  37. ^ Melnick, Alan L. Biological, Chemical, and Radiological Terrorism: Emergency Preparedness and Response for the Primary Care Physician. Springer. 2008: 2. ISBN 9780387472317. 
  38. ^ Hornblum, 1998: p. 91
  39. ^ Frederick Adolf Paola, Robert Walker, Lois Lacivita Nixon (编). Medical Ethics and Humanities. Jones & Bartlett Publishers. 2009: 185–186. ISBN 9780763760632. 
  40. ^ Hammer Breslow, Lauren. "The Best Pharmaceuticals for Children Act of 2002: The Rise of the Voluntary Incentive Structure and Congressional Refusal to Require Pediatric Testing", Harvard Journal of Legislation, Vol. 40
  41. ^ Offit, Paul A. The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis. Yale University Press. 2007: 37. ISBN 9780300126051. 
  42. ^ Goliszek, 2003: p. 228
  43. ^ 43.0 43.1 43.2 Blum, William. Rogue state: a guide to the world's only superpower. Zed Books. 2006: 150–151. ISBN 9781842778272. 
  44. ^ Michael Parenti, The Sword and the Dollar: Imperialism, Revolution, and the Arms Race, St. Martins Press, 1989, pp.74-81, Excerpt available online at:[1] (accessed: 02/18/2010)
  45. ^ Biological Warfare and the National Security State: A Chronology, Tom Burghardt
  46. ^ Cole, 1996: pp. 28-30
  47. ^ 47.0 47.1 Loue, 2000: pp. 26-29
  48. ^ Moreno, 2001: p. 234
  49. ^ Cina & Perper, 2010: p. 95
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  51. ^ How the U.S. Government Exposed Thousands of Americans to Lethal Bacteria to Test Biological Warfare
  52. ^ 52.0 52.1 Loue, 2000: pp. 19–23
  53. ^ 53.0 53.1 53.2 53.3 53.4 53.5 Goliszek, 2003: pp. 132-134
  54. ^ Goliszek, 2003: pp. 130-131
  55. ^ 55.0 55.1 Goliszek, 2003: pp. 136-137
  56. ^ Moreno, 2001: p. 132
  57. ^ LeBaron, Wayne D. America's nuclear legacy. Nova Publishers. 1998: 109–111. ISBN 9781560725565. 
  58. ^ Eileen Welsome. The Plutonium Files: America's Secret Medical Experiments in the Cold War. New York: Dial Press. 1999: 146–148. ISBN 0-385-31402-7. 
  59. ^ 59.0 59.1 LeBaron, Wayne D. America's nuclear legacy. Nova Publishers. 1998: 97–98. ISBN 9781560725565. 
  60. ^ Pacchioli, David, (March 1996) "Subjected to Science", Research/Penn State, Vol. 17, no. 1
  61. ^ Goliszek, 2003: p. 139
  62. ^ America's Deep, Dark Secret. CBS News. April 29, 2004 [February 18, 2010]. 
  63. ^ 63.0 63.1 Abhilash R. Vaishnav. The Tech online edition. The Tech. 1994. 
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  65. ^ Eckart, 2006: p. 263
  66. ^ 66.0 66.1 66.2 Cherbonnier, Alice (October 1, 1997) "Nasal Radium Irradiation of Children Has Health Fallout", Baltimore Chronicle and Sentinel (accessed: 02/19/2010)
  67. ^ Danielle Gordon. The Verdict: No harm, no foul. Bulletin of the Atomic Scientists. January 1996, 52 (1). 
  68. ^ Stewart A. Farber. Nasal Radium Irradiation: Bad Science, Bad Medicine, Bad Ethics. Testimony to U.S. Senate Committee on Governmental Affairs (ACHRE hearings). March 12, 1996. 
  69. ^ Goliszek, 2003: p. 253
  70. ^ "Plutonium Files: How the U.S. Secretly Fed Radioactivity to Thousands of Americans", Democracy Now!, May 5, 2004
  71. ^ LeBaron, Wayne D. America's nuclear legacy. Nova Publishers. 1998: 105. ISBN 9781560725565. 
  72. ^ 72.0 72.1 72.2 72.3 72.4 Goliszek, 2003: pp. 223-225
  73. ^ Operation Castle. Operation Castle. [6/11/2011]. 
  74. ^ Nuclear Issues
  75. ^ Institute of Medicine (U.S.). Committee on Thyroid Screening Related to I-131 Exposure, National Research Council (U.S.). Committee on Exposure of the American People to I-131 from the Nevada Atomic Bomb Tests (编). Exposure of the American people to Iodine-131 from Nevada nuclear-bomb tests: review of the National Cancer Institute report and public health implications. National Academies Press. 1999: 113–114. ISBN 9780309061759.  – deaths taken from 90% survival rate, applied to # of cases
  76. ^ ACHRE Report:New Ethical Questions for Medical Researchers
    "In 1949, the AEC undertook Project Gabriel, a secret effort to study the question of whether the tests could threaten the viability of life on earth. In 1953, Gabriel led to Project Sunshine..."
  77. ^ U.S. Department of Energy, "Report on Project Gabriel", July 1954
  78. ^ Goncalves, Eddie. Britain snatched babies' bodies for nuclear labs. The Guardian (London). June 3, 2001. 
  79. ^ Dundee University Medical School; PDF
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  81. ^ Thomas H. Maugh II, "Eugene Saenger, 90; physician conducted pivotal studies on effects of radiation exposure", Los Angeles Times, October 06, 2007 (accessed: February 18, 2010)
  82. ^ Human Experiments
  83. ^ Cockburn, Alexander; Jeffrey St. Clair. Whiteout: The CIA, Drugs and the Press. New York: Verso. 1998: 157–159. ISBN 1859842585. 
  84. ^ Goliszek, 2003: Ch. 4
  85. ^ Moreno, 2001: pp. 40-43
  86. ^ Freeman, Karen. The Unfought Chemical War. Bulletin of the Atomic Scientists. December 1991: 30–39. 
  87. ^ Pechura, Constance M. & Rall, David P. (编). Veterans at Risk: the health effects of mustard gas and Lewisite. National Academies Press. 1993: 31. ISBN 9780309048323. 
  88. ^ Cina & Perper, 2010: p. 96
  89. ^ Mangold, Tom; Goldberg, Jeff. Plague wars: a true story of biological warfare. Macmillan. 2000: 37. ISBN 9780312203535. 
  90. ^ B.M. Ansell, F. Antonini, L.E. Glynn: "Cantharides blisters in children with rheumatic fever". Clinical Science, November 1953, 12 (4): 367-373.
  91. ^ Hornblum, 1998: p. 216
  92. ^ Cina & Perper, 2010: pp. 92-93
  93. ^ Washington, 2008: pp. 249-262
  94. ^ 94.0 94.1 94.2 94.3 Kaye, Jonathan. "Retin-A's Wrinkled Past", Pennsylvania History Review, Spring 1997.
  95. ^ Hornblum, 1998: p. 320
  96. ^ Ex-Inmates Sue Penn and Kligman over Research. The Pennsylvania Gazette (The University of Pennsylvania). Jan/Feb 2001 [9 November 2009]. 
  97. ^ Hornblum, 2007: p. 52
  98. ^ Goliszek, 2003: p. 226
  99. ^ 99.0 99.1 99.2 99.3 Goliszek, 2003: pp. 152-154
  100. ^ Science, Technology and the CIA
  101. ^ Church Committee; p. 390 "MKULTRA was approved by the DCI [Director of Central Intelligence] on April 13, 1953"
  102. ^ Estabrooks, G.H. Hypnosis comes of age. Science Digest, 44-50, April 1971
  103. ^ Gillmor, D. I Swear By Apollo: Dr. Ewen Cameron and the CIA-Brainwashing Experiments. Montreal: Eden press, 1987.
  104. ^ Scheflin, A.W., & Opton, E.M. The Mind manipulators. New York: Paddington Press, 1978.
  105. ^ Thomas, G. Journey into Madness: The Secret Story of Secret CIA Mind Control and Medical Abuse. New York: Bantam, 1989 (paperback 1990).
  106. ^ Weinstein, H. Psychiatry and the CIA: Victims of Mind Control. Washington, DC: American Psychiatric Press, 1990.
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  108. ^ Otterman, 2007: pp. 21-22
  109. ^ John S. Friedman (编). The secret histories: hidden truths that challenged the past and changed the world. Macmillan. 2005: 146. ISBN 9780312425173. 
  110. ^ Cole, 1996: pp. 31-32
  111. ^ 111.0 111.1 111.2 McCoy, 2006: pp. 28-30
  112. ^ Goliszek, 2003: p. 155
  113. ^ APPENDIX C: Documents Referring To Subprojects1977 Senate MKULTRA Hearing (accessed: 02/18/2010)
  114. ^ 114.0 114.1 Otterman, 2007: pp. 24-25
  115. ^ 115.0 115.1 Cockburn, Alexander; Jeffrey St. Clair. Whiteout: The CIA, Drugs and the Press. New York: Verso. 1998: 206–209. ISBN 1859842585. 
  116. ^ Otterman, 2007: pp. 45-47
  117. ^ 117.0 117.1 117.2 117.3 117.4 117.5 Naomi Klein. 1. The Shock Doctrine: The Rise of Disaster Capitalism. New York: Metropolitan Books. 2007. ISBN 0805079831. 
  118. ^ Goliszek, 2003: pp. 170-171
  119. ^ Marks, John D., Chapter 8, The Search for the Manchurian Candidate
  120. ^ Otterman, 2007: p. 27
  121. ^ Mohr, Clarence L.; Joseph E. Gordon. Tulane: the emergence of a modern university, 1945-1980. LSU Press. 2001: 123. ISBN 9780807125533. 
  122. ^ http://www.archive.org/stream/finalreportofsel01unit#page/390/mode/2up
  123. ^ 123.0 123.1 Estabrooks, G.H. Hypnosis comes of age. Science Digest, 44-50, April 1971
  124. ^ 124.0 124.1 Gillmor, D. I Swear By Apollo. Dr. Ewen Cameron and the CIA-Brainwashing Experiments. Montreal: Eden press, 1987.
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  127. ^ 127.0 127.1 Weinstein, H. Psychiatry and the CIA: Victims of Mind Control. Washington, DC: American Psychiatric Press, 1990.
  128. ^ McCoy, 2006: pp. 50-53
  129. ^ U.S. Has a History of Using Torture – Alfred W. McCoy, Z Magazine.
  130. ^ Sheldon Richman. Did the CIA Conduct Medical Experiments on Detainees?. Counterpunch. June 23, 2010. 
  131. ^ Experiments in Torture: Human Subject Research and Experimentation in the “Enhanced” Interrogation Program, Physicians for Human Rights, June 2010
    See also:
    *Related Publications
    *Outside Academic Experts Respond to Experiments in Torture
    *Complaint to Office of Human Research Protections Regarding Evidence of CIA Violations of Common Rule
    *Experiments in Torture (video)
  132. ^ Experiments in Torture: Medical Group Accuses CIA of Carrying Out Illegal Human Experimentation, Democracy Now!, June 08, 2010
  133. ^ Accounting for Torture: Being Faithful to our Values, (video) National Religious Campaign Against Torture (cited by PHR)
  134. ^ Risen, James. Medical Ethics Lapses Cited in Interrogations. New York Times. 6 June 2010. 
  135. ^ ICRC Report on the Treatment of Fourteen “High Value Detainees” in CIA Custody, International Committee of the Red Cross, 14 February 2007
  136. ^ California Jail to Test Ray Gun on Prisoners. Democracy Now!. August 23, 2010. 
  137. ^ Theory improved treatment and understanding of stuttering: Ethics concerns led researchers to conceal the experiment Decades later, the experiment's victims struggle to make sense of their past, Jim Dyer, San Jose Mercury News, Monday, June 11, 2001 (accessed: 02/17/2010)
  138. ^ Loue, 2000: p. 30
  139. ^ Deadly Medicine: FDA Fails to Regulate Rapidly Growing Industry of Overseas Drug Testing, Democracy Now!, December 17, 2010
  140. ^ Barlett, Donald L. & Steele, James B. Deadly Medicine. Vanity Fair. January 2011. 
  141. ^ Washington, 2008: pp. 60-63
  142. ^ Savitt, Todd Lee. Medicine and slavery: the diseases and health care of Blacks in antebellum Virginia. University of Illinois Press. 2002: 299. ISBN 9780252008740. 
  143. ^ Shamoo & Resnick, 2009: p. 239
  144. ^ Albarelli Jr., H.P.; Kaye, Jeffrey S.; "The Hidden Tragedy of the CIA's Experiments on Children", Truthout, Wednesday 11 August 2010
  145. ^ Whitaker, Robert. Mad in America: Bad Science, Bad Medicine, and the Enduring Mistreatment of the Mentally Ill. Basic Books. 2010: 315. ISBN 9780465020140. 
  146. ^ http://www.npr.org/templates/story/story.php?storyId=87975196
  147. ^ http://www.museumofdisability.org/newyork_timeline_1960s.asp
  148. ^ Cina & Perper, 2010: p. 92
  149. ^ Hornblum, 1999: p. 80
  150. ^ Dober, Gregory "Cheaper than Chimpanzees: Expanding the Use of Prisoners in Medical Experiments", Prison Legal News, VOL. 19 No. 3, March 2008
  151. ^ Blum, William. Rogue state: a guide to the world's only superpower. Zed Books. 2006: 152–154. ISBN 9781842778272. 
  152. ^ Goldzieher JW, Moses LE, Averkin E, Scheel C, Taber BZ. A placebo-controlled double-blind crossover investigation of the side effects attributed to oral contraceptives. Fertil Steril. 1971 Sep;22(9):609-23. “PMID4105854”
  153. ^ Levine, Robert J. “Ethics and regulation of clinical research, 2nd ed”. Yale University Press, 1986, p.71-72. ISBN Special:BookSources/0806711124
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  155. ^ Brian Ross. Test of Controversial Artificial Blood Product a Failure. ABC News, "The Blotter". May 23, 2007. 
  156. ^ Ed Edelson. Experimental Blood Substitutes Unsafe, Study Finds. ABC News. April 28 2008[何时?]. 
  157. ^ Goliszek, 2003: pp. 108-109
  158. ^ Science, Technology, and the CIA, National Security Archive Electronic Briefing Book, Jeffrey T. Richelson, Editor, September 10, 2001 (accessed: 02/18/2010)
  159. ^ "U.S. Senate: Joint Hearing before The Select Committee on Intelligence and The Subcommittee on Health and Scientific Research of the Committee on Human Resources", 95th Cong., 1st Sess. August 3, 1977.
  160. ^ Final report of ACHRE
  161. ^ Henry N. Pontell, Gilbert Geis (编). International handbook of white-collar and corporate crime. Springer. 2007: 62. ISBN 9780387341101. 

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  • Hornblum, Allen M. Acres of skin: human experiments at Holmesburg Prison : a story of abuse and exploitation in the name of medical science. Routledge. 1998. ISBN 9780415919906. 
  • Hornblum, Allen M. Sentenced to Science: One Black Man's Story of Imprisonment in America. The Pennsylvania State University Press. 2007. ISBN 9780271033365. 
  • Lederer, Susan E. Subjected to Science: Human Experimentation in America Before the Second World War. JHU Press. 1997. ISBN 9780801857096. 
  • Loue, Sana. Textbook of research ethics: theory and practice. Springer. 2000. ISBN 9780306464485. 
  • McCoy, Alfred W. A question of torture: CIA interrogation, from the Cold War to the War on Terror. New York: Metropolitan Books. 2006. ISBN 978-0-8050-8041-4. 
  • Moreno, Jonathan D. Undue Risk: Secret State Experiments on Humans. Routledge. 2001. ISBN 0415928354. 
  • Otterman, Michael. American torture: from the Cold War to Abu Ghraib and beyond. Melbourne Univ. Publishing. 2007. ISBN 9780522853339. 
  • David J. Rothman. Strangers at the Bedside: A History of How Law and Bioethics Transformed Medical Decision Making. Basic Books. 1992. ISBN 9780465082100. 
  • Shamoo, Adil E.; Resnik, David B. Responsible Conduct of Research. Oxford University Press US. 2009. ISBN 9780195368246. 
  • Washington, Harriet A. Medical Apartheid: The Dark History of Medical Experimentation on Black Americans from Colonial Times to the Present. Random House. 2008. ISBN 9780767915472. 

Further resources

General

Biological warfare and disease/pathogen experiments

Human radiation experiments

Books

Government documents

Journals

Psychological/torture/interrogation experiments

Video