表皮生长因子受体：修订间差异

Epidermal growth factor receptor; 表皮生长因子受体
	表皮生长因子受体的胞外结构域与表皮生长因子结合的复合体，引自PDB1nql
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0
标识
代号	EGFR; ERBB; ERBB1; HER1; PIG61; mENA
扩展标识	遗传学：131550 鼠基因：95294 同源基因：74545 ChEMBL: 203 GeneCards: EGFR Gene
EC編號	2.7.10.1
基因本体论描述
分子功能	· double-stranded DNA binding; · MAP kinase kinase kinase activity; · protein tyrosine kinase activity; · transmembrane receptor protein tyrosine kinase activity; · receptor signaling protein tyrosine kinase activity; · transmembrane signaling receptor activity; · epidermal growth factor-activated receptor activity; · protein binding; · ATP binding; · enzyme binding; · protein phosphatase binding; · nitric-oxide synthase regulator activity; · identical protein binding; · protein heterodimerization activity; · actin filament binding;
细胞成分	· Golgi membrane; · extracellular space; · nucleus; · cytoplasm; · endosome; · endoplasmic reticulum membrane; · plasma membrane; · endosome membrane; · membrane; · integral to membrane; · basolateral plasma membrane; · AP-2 adaptor complex; · nuclear membrane; · membrane raft; · perinuclear region of cytoplasm; · Shc-EGFR complex;
生物过程	· MAPK cascade; · activation of MAPKK activity; · ossification; · embryonic placenta development; · hair follicle development; · response to stress; · signal transduction; · cell surface receptor signaling pathway; · epidermal growth factor receptor signaling pathway; · activation of phospholipase C activity; · axon guidance; · salivary gland morphogenesis; · cell proliferation; · positive regulation of cell proliferation; · fibroblast growth factor receptor signaling pathway; · cell-cell adhesion; · cerebral cortex cell migration; · positive regulation of cell migration; · positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S; · positive regulation of catenin import into nucleus; · negative regulation of epidermal growth factor receptor signaling pathway; · negative regulation of protein catabolic process; · positive regulation of phosphorylation; · activation of phospholipase A2 activity by calcium-mediated signaling; · negative regulation of apoptotic process; · positive regulation of MAP kinase activity; · innate immune response; · positive regulation of nitric oxide biosynthetic process; · positive regulation of DNA repair; · positive regulation of DNA replication; · protein autophosphorylation; · neurotrophin TRK receptor signaling pathway; · phosphatidylinositol-mediated signaling; · positive regulation of fibroblast proliferation; · digestive tract morphogenesis; · positive regulation of epithelial cell proliferation; · regulation of peptidyl-tyrosine phosphorylation; · regulation of nitric-oxide synthase activity; · protein insertion into membrane; · positive regulation of protein kinase B signaling cascade; · morphogenesis of an epithelial fold; · response to UV-A;
	Sources: Amigo / QuickGO
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2013年12月11日 (三) 21:28的版本

表皮生长因子受体（英語：epidermal growth factor receptor，简称为EGFR、ErbB-1或HER1）是一类名为表皮生长因子家族（EGF-家族）的细胞外蛋白配体的细胞表面受体^[2] 。

表皮生长因子受体是ErbB受体家族家族的成员之一，ErbB家族是包含四种紧密联系蛋白的亚家族，这四种蛋白分别是受体酪氨酸激酶类：EGFR（ErbB-1）HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影响EGFR表达或活性的突变可能导致癌症^[3]。

表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的，科恩与丽塔·列维-蒙塔尔奇尼因发现生长因子类而共同获得了1986年诺贝尔生理学或医学奖。

参考文献

^ Kathryn M. Ferguson, Mitchell B. Berger, Jeannine M. Mendrola, Hyun Soo Cho, Daniel J. Leahy, Mark A. Lemmon. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 2003-02, 11 (2): 507–517 [2019-05-26]. ISSN 1097-2765. PMID 12620237.
^ Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys. 2004, 59 (2 Suppl): 21–6. PMID 15142631. doi:10.1016/j.ijrobp.2003.11.041.
^ Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. ErbB receptors: from oncogenes to targeted cancer therapies. J. Clin. Invest. 2007, 117 (8): 2051–8. PMC 1934579 . PMID 17671639. doi:10.1172/JCI32278. 已忽略未知参数|month=（建议使用|date=） (帮助)

深入阅读

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外部链接

醫學主題詞表（MeSH）：Epidermal Growth Factor Receptor

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[1] Kathryn M. Ferguson, Mitchell B. Berger, Jeannine M. Mendrola, Hyun Soo Cho, Daniel J. Leahy, Mark A. Lemmon. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 2003-02, 11 (2): 507–517 [2019-05-26]. ISSN 1097-2765. PMID 12620237.

[pmid15142631-2] Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys. 2004, 59 (2 Suppl): 21–6. PMID 15142631. doi:10.1016/j.ijrobp.2003.11.041.

[pmid17671639-3] Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. ErbB receptors: from oncogenes to targeted cancer therapies. J. Clin. Invest. 2007, 117 (8): 2051–8. PMC 1934579 . PMID 17671639. doi:10.1172/JCI32278. 已忽略未知参数|month=（建议使用|date=） (帮助)

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