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副乾酪乳桿菌：修订间差异

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==臨床研究及應用==
==臨床研究及應用==
副乾酪乳桿菌已被鑑定為具有益生菌性質的細菌<ref name="Probiotics 1">{{cite journal |last=Orlando |first=A. |last2=Refolo |first2=M. G. |last3=Messa |first3=C. |last4=Amati |first4=L. |last5=Lavermicocca |first5=P. |last6=Guerra |first6=V. |last7=Russo |first7=F. |title=Antiproliferative and Proapoptotic Effects of Viable or Heat-Killed IMPC2.1 and GG in HGC-27 Gastric and DLD-1 Colon Cell Lines |journal=''[[Nutrition and Cancer]]'' |volume=64 |issue=7 |pages=1103–1111 |date=2012-10 |doi=10.1080/01635581.2012.717676 |language=en }}</ref><ref name=Molin-Goran>{{cite journal |last1=Molin |first1=G.|last2=Jeppsson |first2=B. |last3=Johansson |first3=M.-L. |author4=Ahrné, S. |author5=Nobaek, S. |author6=Ståhl, M. |author7= Bengmark, S. |title=Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines |journal=''[[Journal of Applied Bacteriology]]'' |date=1993-03 |volume=74 |issue=3 |pages=314–323 |doi=10.1111/j.1365-2672.1993.tb03031.x |pmid=8468264 |language=en }}</ref>。
副乾酪乳桿菌已被鑑定為具有益生菌性質的細菌<ref name="Probiotics 1">{{cite journal |last=Orlando |first=A. |last2=Refolo |first2=M. G. |last3=Messa |first3=C. |last4=Amati |first4=L. |last5=Lavermicocca |first5=P. |last6=Guerra |first6=V. |last7=Russo |first7=F. |title=Antiproliferative and Proapoptotic Effects of Viable or Heat-Killed IMPC2.1 and GG in HGC-27 Gastric and DLD-1 Colon Cell Lines |journal=Nutrition and Cancer |volume=64 |issue=7 |pages=1103–1111 |date=2012-10 |doi=10.1080/01635581.2012.717676 |language=en }}</ref><ref name=Molin-Goran>{{cite journal |last1=Molin |first1=G.|last2=Jeppsson |first2=B. |last3=Johansson |first3=M.-L. |author4=Ahrné, S. |author5=Nobaek, S. |author6=Ståhl, M. |author7= Bengmark, S. |title=Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines |journal=Journal of Applied Bacteriology |date=1993-03 |volume=74 |issue=3 |pages=314–323 |doi=10.1111/j.1365-2672.1993.tb03031.x |pmid=8468264 |language=en }}</ref>。


===過敏性呼吸道疾病(過敏性鼻炎、結膜炎與氣喘)===
⚫
[[胃腸道]]細胞的[[细胞凋亡|凋亡]]和生長易受已熱滅活和有活力的IMPC2.1菌株的影響<ref name="Probiotics 1" />。
副乾酪乳桿菌已被證明可抑制[[大腸桿菌]]的[[细菌]]活性，而大腸桿菌是引致[[腹瀉]]的常見菌種，因此副乾酪乳桿菌被應用於治療腹瀉<ref name="Livestrong" /><ref>{{cite journal |last=Caridi |first=A. |title=Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei |journal=''[[Journal of Industrial Microbiology & Biotechnology]]'' |issn=1367-5435 |volume=29 |issue=6 |year=2002 |pages=303–308 |doi=10.1038/sj.jim.7000300 |pmid=12483469 |language=en }}</ref>。包含副乾酪乳桿菌的活菌製劑可與常規療法結合使用，以治療[[溃疡性结肠炎]]<ref name=Ghouri2014>{{cite journal| first1=Yezaz A |last1=Ghouri |first2= David M |last2=Richards |first3= Erik F |last3=Rahimi|first4= Joseph T |last4=Krill|first5= Katherine A |last5= Jelinek|first6=Andrew W |last6=DuPont|pmc=4266241|title=Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease|date=9 December 2014 |doi =10.2147/CEG.S27530|journal=Clin Exp Gastroenterol|volume=7|pages= 473–487 |pmid=25525379}}</ref>。一項系統綜述為副乾酪乳桿菌LP-33菌株治療變應性鼻炎提供了有益的臨床和免疫學作用的重要證據。<ref>{{Cite journal|last=Guvenc|first=I. A.|last2=Muluk|first2=N. Bayar|last3=Mutlu|first3=F. S.|last4=Eski|first4=E.|last5=Altintoprak|first5=N.|last6=Oktemer|first6=T.|last7=Cingi|first7=C.|date=2016-07-20|title=Do probiotics have a role in the treatment of allergic rhinitis?: A comprehensive systematic review and meta analysis|journal=American Journal of Rhinology & Allergy|volume=30|issue=5|pages=157–175|doi=10.2500/ajra.2016.30.4354|issn=1945-8932|pmid=27442711}}</ref>
副乾酪乳桿菌LP-33菌株治療[[過敏性]]鼻炎提供了有益的臨床和免疫學作用的重要證據。<ref>{{Cite journal|last=Guvenc|first=I. A.|last2=Muluk|first2=N. Bayar|last3=Mutlu|first3=F. S.|last4=Eski|first4=E.|last5=Altintoprak|first5=N.|last6=Oktemer|first6=T.|last7=Cingi|first7=C.|date=2016-07-20|title=Do probiotics have a role in the treatment of allergic rhinitis?: A comprehensive systematic review and meta analysis|journal=American Journal of Rhinology & Allergy|volume=30|issue=5|pages=157–175|doi=10.2500/ajra.2016.30.4354|issn=1945-8932|pmid=27442711}}</ref><ref>{{Cite journal|last1=Wang|first1=Ming-Fuu|last2=Lin|first2=Hsiao-Chuan|last3=Wang|first3=Ying-Yu|last4=Hsu|first4=Ching-Hsiang|date=2004-03-30|title=Treatment of perennial allergic rhinitis with lactic acid bacteria|journal=Pediatric Allergy and Immunology|volume=15|issue=2|pages=152-8|doi=10.7025/HEJ.200409.0005|pmid=15059192|issn=0905-6157}}</ref>


副乾酪乳桿菌BRAP01菌株 是誘導台灣個體產生γ-干擾素 (IFN-γ)/介白素-10(IL-10) 的主要菌株。
⚫
副乾酪乳桿菌的D3-5菌株經過「[[熱殺]]」（{{lang|en|heat killed}}）後，其細胞壁會析出{{tsl|en|Lipoteichoic acid|脂磷壁酸}}，可改善實驗鼠與衰老相關的腸道滲出、炎症，並改善其身體和認知功能<ref>{{Cite journal |last1=Wang |first1=Shaohua |last2=Ahmadi |first2=Shokouh |last3=Nagpal |first3=Ravinder |last4=Jain |first4=Shalini |last5=Mishra |first5=Sidharth P. |last6=Kavanagh |first6=Kylie |last7=Zhu |first7=Xuewei |last8=Wang |first8=Zhan |last9=McClain |first9=Donald A. |last10=Kritchevsky |first10=Stephen B. |last11=Kitzman |first11=Dalane W. |date=2019-12-08 |title=Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice |journal=''[[GeroScience]]'' |doi=10.1007/s11357-019-00137-4 |issn=2509-2723 |pmc=7031475 |language=en }}</ref>。
<ref>{{Cite journal|last1=Ho|first1=Y-H
|last2=Huang|first2=Y-T|last3=Lu|first3=Y-C|last4=Lee|first4=S-Y|last5=Tsai|first5=M-F|last6=Hung|first6=S-P|last7=Hsu|first7=T-Y|date=2016-10-11|title=Effects of gender and age on immune responses of human peripheral blood mononuclear cells to probiotics: A large scale pilot study|journal=The journal of nutrition, health & aging|volume=21|issue=5|pages=521-526|doi=10.1007/s12603-016-0818-7|pmid=28448082|issn=1279-7707}}</ref>


副乾酪乳桿菌 HB89菌株 可減輕「細[[懸浮微粒]]( PM 2.5)」刺激的呼吸道過敏。
⚫
除了各種和消化道相關的病變，2011年，副乾酪乳桿菌首次用於預防[[龋齿]]。這是因為副乾酪乳桿菌能夠識別{{tsl|de|Streptococcus mutans|變形鏈球菌}}，使其附著並導致結塊，而變形鏈球菌因此無法再附著在牙齒上，而會被唾液沖洗掉或在刷牙時被除去<ref>{{cite journal |url=http://www.organobalance.de/Berichte/2011%20Dez%20Technology%20Review%20Screen.pdf |format=PDF (77 kB) |author=Anwen Roberts |title=Biotech: mit Bakterien gegen karies |trans-title=生物技術：與細菌對抗齲齒 |journal=''[[Technology Review]]'' |page=12 |date=2011-12 |language=de |access-date=2021-01-05 |archive-date=2021-01-07 |archive-url=https://web.archive.org/web/20210107224559/http://organobalance.de/Berichte/2011%20Dez%20Technology%20Review%20Screen.pdf }}</ref>。
<ref>{{Citejournal|last1=Lin|first1=Ching-Hung|last2=Tseng|first2=Chia-Yi|last3=Chao|first3=Ming-Wei|date=2020-12-07|title=Administration of Lactobacillus paracasei HB89 mitigates PM2.5-induced enhancement of inflammation and allergic airway response in murine asthma model|journal=PLoS One|volume=15|issue=12|pages=e0243062|doi=10.1371/journal.pone.0243062|pmid=33284823|issn=1932-6203|pmc=7721166}}</ref>

對於過敏性鼻炎(AR)，每日口服100億以上菌數(1x10<sup>10</sup>CFU)的副乾酪乳桿菌(食用前均保存於4°C中)並持續食用8週的時間，可改善鼻搔癢(AR的關鍵臨床特徵)並減少促發炎介質 IL-5 分泌。
<ref>{{Cite journal|last1=Perrin |first1=Y|last2=Nutten |first2= S|last3=Audran|first3= R|display-authors=et al.|date=2014-01-06|title=Comparison of two oral probiotic preparations in a randomized crossover trial highlights a potentially beneficial effect of Lactobacillus paracasei NCC2461 in patients with allergic rhinitis|journal=Clinical and Translational Allergy|volume=4|issue=1|pages=1|doi=10.1186/2045-7022-4-1|pmid=24393277}}</ref>

===異位性皮膚炎、蕁麻疹===
口服副乾酪乳桿菌KBL382菌株可顯著減少與 [[異位性皮膚炎]](AD) 相關的皮膚損傷、表皮增厚、免疫球蛋白 E 的血清水平和免疫細胞浸潤。
<ref>{{Cite journal|last1=Kim|first1=WK|last2=Jang|first2= YJ|last3=Han|first3=DH
|display-authors=et al.|date=2020-11-09|title=Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota|journal=Gut Microbes|volume=12|issue=1|pages=1-14|doi=10.1080/19490976.2020.1819156|pmid=33016202|issn=1949-0976|pmc=7553742}}</ref>

===流行性感冒===
口服熱滅活的 副乾酪乳桿菌MoLac-1菌株增加了脾臟中 NK 細胞的比例，並改善了小鼠 [[流行性感冒病毒]](IFV) 感染的症狀。
<ref>{{Cite journal|last1=Iwabuchi |first1=Noriyuki|last2=Yonezawa|first2=Sumiko|last3=Odamaki|first3= Toshitaka|display-authors=et al.|date=November 2012|title=Immunomodulating and anti-infective effects of a novel strain of Lactobacillus paracasei that strongly induces interleukin-12|journal=FEMS Immunology & Medical Microbiology|volume=66|issue=2|pages=230-9|doi=10.1111/j.1574-695X.2012.01003.x|pmid=22775119|issn=0928-8244}}</ref>

===普通感冒===
副乾酪乳桿菌MCC1849菌株 有可能提高易感受試者對[[普通感冒]]感染的抵抗力，並保持理想的情緒狀態，即使在精神壓力條件下也是如此。
<ref>{{Cite journal|last1=Murata|first1=M|last2=Kondo|first2=J|last3= Iwabuchi|first3=N|display-authors=et al.|date=December 2018|title=Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults|journal=Beneficial Microbes|volume=9|issue=6|pages=855-864|doi=10.3920/BM2017.0197|pmid=30099891|issn=1876-2883}}</ref>

===新型冠狀病毒感染===
副乾酪乳桿菌DG 菌株顯著誘導了參與保護性抗病毒免疫的基因表達，並阻止了由 SARS-CoV-2 感染引發的促炎基因的表達。
<ref>{{Cite journal|last1=Salaris |first1=Claudio|last2=Scarpa |first2= Melania|last3=Elli|first3=Marina|display-authors=et al.|date= Jan-Dec 2021|title=Lacticaseibacillus paracasei DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cells|journal=Gut microbes|volume=13|issue=1|pages=19490976|doi=10.1080/19490976.2021.1961970|pmid=34365895|issn=1949-0976|pmc= PMC8354669}}</ref>

===發炎性腸道疾病===
包含副乾酪乳桿菌的活菌製劑可與常規療法結合使用，以治療[[潰瘍性結腸炎]]<ref name=Ghouri2014>{{cite journal| first1=Yezaz A |last1=Ghouri |first2= David M |last2=Richards |first3= Erik F |last3=Rahimi|first4= Joseph T |last4=Krill|first5= Katherine A |last5= Jelinek|first6=Andrew W |last6=DuPont|pmc=4266241|title=Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease|date=9 December 2014 |doi =10.2147/CEG.S27530|journal=Clin Exp Gastroenterol|volume=7|pages= 473–487 |pmid=25525379}}</ref>。
⚫
副乾酪乳桿菌的D3-5菌株經過「熱殺」（{{lang|en|heat killed}}）後，其細胞壁會析出{{tsl|en|Lipoteichoic acid|脂磷壁酸}}，可改善實驗鼠與衰老相關的腸道滲出、炎症，並改善其身體和認知功能<ref>{{Cite journal |last1=Wang |first1=Shaohua |last2=Ahmadi |first2=Shokouh |last3=Nagpal |first3=Ravinder |last4=Jain |first4=Shalini |last5=Mishra |first5=Sidharth P. |last6=Kavanagh |first6=Kylie |last7=Zhu |first7=Xuewei |last8=Wang |first8=Zhan |last9=McClain |first9=Donald A. |last10=Kritchevsky |first10=Stephen B. |last11=Kitzman |first11=Dalane W. |date=2019-12-08 |title=Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice |journal=GeroScience |doi=10.1007/s11357-019-00137-4 |issn=2509-2723 |pmc=7031475 |language=en }}</ref>。

===齲齒===
⚫
除了各種和消化道相關的病變，2011年，副乾酪乳桿菌首次用於預防[[龋齿]]。這是因為副乾酪乳桿菌能夠識別{{tsl|de|Streptococcus mutans|變形鏈球菌}}，使其附著並導致結塊，而變形鏈球菌因此無法再附著在牙齒上，而會被唾液沖洗掉或在刷牙時被除去<ref>{{cite journal |url=http://www.organobalance.de/Berichte/2011%20Dez%20Technology%20Review%20Screen.pdf |format=PDF (77 kB) |author=Anwen Roberts |title=Biotech: mit Bakterien gegen karies |trans-title=生物技術：與細菌對抗齲齒 |journal=Technology Review |page=12 |date=2011-12 |language=de |access-date=2021-01-05 |archive-date=2021-01-07 |archive-url=https://web.archive.org/web/20210107224559/http://organobalance.de/Berichte/2011%20Dez%20Technology%20Review%20Screen.pdf }}</ref>。

===腹瀉===
副乾酪乳桿菌已被證明可抑制[[大腸桿菌]]的[[细菌]]活性，而大腸桿菌是引致[[腹瀉]]的常見菌種，因此副乾酪乳桿菌被應用於治療腹瀉<ref>{{cite journal |last=Caridi |first=A. |title=Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei |journal=Journal of Industrial Microbiology & Biotechnology |issn=1367-5435 |volume=29 |issue=6 |year=2002 |pages=303–308 |doi=10.1038/sj.jim.7000300 |pmid=12483469 |language=en }}</ref>。包含副乾酪乳桿菌的活菌製劑可與常規療法結合使用，以治療[[溃疡性结肠炎]]<ref name=Ghouri2014>{{cite journal| first1=Yezaz A |last1=Ghouri |first2= David M |last2=Richards |first3= Erik F |last3=Rahimi|first4= Joseph T |last4=Krill|first5= Katherine A |last5= Jelinek|first6=Andrew W |last6=DuPont|pmc=4266241|title=Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease|date=9 December 2014 |doi =10.2147/CEG.S27530|journal=Clin Exp Gastroenterol|volume=7|pages= 473–487 |pmid=25525379}}</ref>。一項系統綜述為副乾酪乳桿菌LP-33菌株治療變應性鼻炎提供了有益的臨床和免疫學作用的重要證據。<ref>{{Cite journal|last=Guvenc|first=I. A.|last2=Muluk|first2=N. Bayar|last3=Mutlu|first3=F. S.|last4=Eski|first4=E.|last5=Altintoprak|first5=N.|last6=Oktemer|first6=T.|last7=Cingi|first7=C.|date=2016-07-20|title=Do probiotics have a role in the treatment of allergic rhinitis?: A comprehensive systematic review and meta analysis|journal=American Journal of Rhinology & Allergy|volume=30|issue=5|pages=157–175|doi=10.2500/ajra.2016.30.4354|issn=1945-8932|pmid=27442711}}</ref>

===幽門螺旋桿菌感染===
副乾酪乳桿菌顯示出對[[幽門螺旋桿菌]]的抑菌和殺菌活性。
<ref>{{Cite journal|last1=Saracino|first1=IM|last2=Pavoni |first2=M|last3=Saccomanno|first3=L|display-authors=et al.|date=2020-05-01|title=Antimicrobial Efficacy of Five Probiotic Strains Against Helicobacter pylori|journal=Antibiotics|volume=9|issue=5|pages=244|doi=10.3390/antibiotics9050244|pmid=32403331|issn=2079-6382|pmc=7277513}}</ref>

===大腸激躁症===
副乾酪乳桿菌可減輕胃腸道症狀的嚴重程度，並改善某些[[大腸激躁症]](IBS) 亞型個體的心理健康。
<ref>{{Cite journal|last1=Lewis|first1=Erin D|last2=Antony |first2= Joseph M|last3=Crowley|first3= David C|display-authors=et al.|date=2020-04-21|title=Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study|journal=Nutrients|volume=12|issue=4|pages=1159|doi=10.3390/nu12041159|pmid= 32326347|issn=2072-6643}}</ref>

===癌症===
⚫
胃癌和結腸癌細胞的[[细胞凋亡|凋亡]]和生長易受已熱滅活和有活力的IMPC2.1菌株的影響<ref name="Probiotics 1" />。


== Health concerns ==
== Health concerns ==

2022年10月19日 (三) 08:59的版本

副乾酪乳桿菌
科学分类 编辑
域： 细菌域 Bacteria
界： 细菌界 Bacteria
门： 厚壁菌门 Firmicutes
纲： 芽孢杆菌纲 Bacilli
目： 乳杆菌目 Lactobacillales
科： 乳杆菌科 Lactobacillaceae
属： 乳杆菌属 Lactobacillus
种：
副乾酪乳桿菌 L. paracasei
二名法
Lactobacillus paracasei
Collins, Phillips & Zanoni, 1989

副乾酪乳桿菌（學名：Lactobacillus paracasei），常以其縮寫稱呼為LP菌，是一種革蘭氏陽性菌，乳桿菌屬中的一菌種。 為常見的益生菌。副乾酪乳桿菌以偏利共生形式運作。常見於與人類相關的棲息地，包括人體內的腸道、口腔，以至人體外的糞渠、青貯飼料及前述的奶製品[1]。正如「乳桿菌」這名字所指，本菌種有著與芽孢桿菌屬相似的桿狀形態，寬約2.0到4.0μm，長約0.8到1.0μm。

1989年，透過DNA-DNA分子交雜法（日语：DNA-DNA分子交雑法）的結果，科學家將NCDO 151（=ATCC 25302）菌株從乾酪乳桿菌分離出來[2]。 現時，科學家從不同的環境中分離出34種不同的菌株，當中有16種是從奶製品分離出來，10種從植物分離出來，8種從人類或其他動物的消化道分離出來[3]。本物種無論是從基因型或從表型都難以從其他諸如乾酪乳桿菌或鼠李糖乳桿菌（英语：Lactobacillus rhamnosus）（Lactobacillus rhamnosus（英语：Lactobacillus rhamnosus））等其他物種分辨過來[4]。然而，科學家還是可以透過這些菌的發酵譜來將之分辨開來[5]。本菌種專門用於生物食品處理程序，以及用於製作營養補充劑，特別是幫助有消化道不適的病患[6]。

儘管益生菌被認為是安全的，但它們可能引起細菌與宿主的相互作用以及對健康的不利影響。在某些情況下，使用益生菌可能會導致菌血症[7][8]。現時尚未確定益生菌療法的益生菌菌株、使用頻率、劑量和持續時間之間的關係[7]。

生理学

副乾酪乳桿菌在生理学屬於革蘭氏陽性菌，兼性異發酵，非芽孢形成的微生物[9]。副乾酪乳桿菌的細胞通常為桿棒狀，大小範圍為寬度2.0μm至4.0μm，長度0.8至1.0μm[4]。這種生物體是不運動的。副乾酪乳桿菌細胞通常具有方形末端，並且可以單一形式或鏈狀存在[4]。

副乾酪乳桿菌的最佳生長溫度範圍是 在10至37°C[10]。當溫度超過40°C，乳桿菌就不會再生長。然而，即使在最高溫度72°C下，乳桿菌仍然可存活約40秒[4]。由於副乾酪乳桿菌是兼性（英语：facultative）異發酵的：大多數菌株會產生乳酸。

副乾酪乳桿菌是正常人類腸道菌群（英语：microbiota）的一部分[11][12]。副乾酪乳桿菌無論是在人類胃腸道或一般的植物，均為其常見的棲所[9]。天然發酵的蔬菜、牛奶和肉也類可能含有副乾酪乳桿菌[10]。副乾酪乳桿菌8700：2菌株已從健康的人的胃腸道黏膜和糞便中分離出來[11]。8700:2菌株可分解果寡糖和菊粉，而菌株同時可在兩者上快速生長並產生乳酸作為最終產物[12]。

系統發生學

副乾酪乳桿菌屬於細菌界厚壁菌門芽孢桿菌綱乳桿菌目的乳桿菌科（英语：Lactobacillaceae）[4]。關於副乾酪乳桿菌與乾酪乳桿菌的命名（英语：nomenclature）爭論一直都是激烈的辯論議題。 Most of the species profiled as L. casei or L. paracasei have been found to be part of the same species.[3] In 1989, it was proposed that L. paracasei be designated a subspecies (paracasei) to account for the species that it shares DNA 同源 with.[4] It has been shown their names have been used interchangeably in scientific literature.[3] 16S 核糖体RNA sequence 同源 has confirmed the relatedness between these species.[4]

Historically, the difference between Lactobacillus paracasei and other lactobacilli has been based on 生物化学 characteristics. There is an approximately 90% sequence identity between 卡塞伊杰罗拉, paracasei, and rhamnosus.[3] However, there are some differential criteria that are commonly used to differentiate between them. These differential criteria include nutritional requirements and growth environment.[3] L. paracasei has been found to show specific differences with other Lactobacillus spp. in that it is somewhat heat resistant, grows well in ripening cheese, and it has high 蛋白酶解 activity.[11]

L. paracasei has been found to have 34 strains.[3] These strains have been isolated from various countries around the world. Although there is a small correlation between 系统发生学 relatedness and origin of isolation, currently there is not enough evidence to support direct proof of the relationship.[3]

Genomics

L. paracasei's genome contains circular 脱氧核糖核酸 and varies slightly among the different strains isolated. On average, the 基因組 are 2.9 to 3.0 million base pairs (commonly abbreviated Mb). It has a GC含量 between 46.2 and 46.6% and is predicted to encode about 2800 to 3100 proteins. The difference in the genomes of these strains lies in variant cell envelope（英语：cell envelope）s, secretory protein（英语：secretory protein）s, and 多糖. Many of the commonly coded proteins are cell-surface associated cell-wall 水解酶s that protect the cell against 细胞凋亡. These enzymes have been shown to provide cellular protection to human 上皮組織 cells.[3]

Genetic diversity for the different L. paracasei genomes was assessed using 多位点序列分型 (MLST) and amplified fragment length polymorphism（英语：amplified fragment length polymorphism） (AFLP). MLST is a technique used for classifying microbes by the use of DNA fragments from essential genes of the organism.[13] AFLP is a 聚合酶链式反应 (PCR) tool used in 遺傳指紋分析 to amplify a desired 脱氧核糖核酸 fragment with the use of 限制酶 and 配體.[14]

臨床研究及應用

副乾酪乳桿菌已被鑑定為具有益生菌性質的細菌[1][11]。

過敏性呼吸道疾病(過敏性鼻炎、結膜炎與氣喘)

副乾酪乳桿菌LP-33菌株治療過敏性鼻炎提供了有益的臨床和免疫學作用的重要證據。[15][16]

副乾酪乳桿菌BRAP01菌株 是誘導台灣個體產生γ-干擾素 (IFN-γ)/介白素-10(IL-10) 的主要菌株。 [17]

副乾酪乳桿菌 HB89菌株 可減輕「細懸浮微粒( PM 2.5)」刺激的呼吸道過敏。 [18]

對於過敏性鼻炎(AR)，每日口服100億以上菌數(1x1010CFU)的副乾酪乳桿菌(食用前均保存於4°C中)並持續食用8週的時間，可改善鼻搔癢(AR的關鍵臨床特徵)並減少促發炎介質 IL-5 分泌。 [19]

異位性皮膚炎、蕁麻疹

口服副乾酪乳桿菌KBL382菌株可顯著減少與 異位性皮膚炎(AD) 相關的皮膚損傷、表皮增厚、免疫球蛋白 E 的血清水平和免疫細胞浸潤。 [20]

流行性感冒

口服熱滅活的 副乾酪乳桿菌MoLac-1菌株增加了脾臟中 NK 細胞的比例，並改善了小鼠 流行性感冒病毒(IFV) 感染的症狀。 [21]

普通感冒

副乾酪乳桿菌MCC1849菌株 有可能提高易感受試者對普通感冒感染的抵抗力，並保持理想的情緒狀態，即使在精神壓力條件下也是如此。 [22]

新型冠狀病毒感染

副乾酪乳桿菌DG 菌株顯著誘導了參與保護性抗病毒免疫的基因表達，並阻止了由 SARS-CoV-2 感染引發的促炎基因的表達。 [23]

發炎性腸道疾病

包含副乾酪乳桿菌的活菌製劑可與常規療法結合使用，以治療潰瘍性結腸炎[24]。 副乾酪乳桿菌的D3-5菌株經過「熱殺」（heat killed）後，其細胞壁會析出脂磷壁酸，可改善實驗鼠與衰老相關的腸道滲出、炎症，並改善其身體和認知功能[25]。

齲齒

除了各種和消化道相關的病變，2011年，副乾酪乳桿菌首次用於預防龋齿。這是因為副乾酪乳桿菌能夠識別變形鏈球菌（德语：Streptococcus mutans），使其附著並導致結塊，而變形鏈球菌因此無法再附著在牙齒上，而會被唾液沖洗掉或在刷牙時被除去[26]。

腹瀉

副乾酪乳桿菌已被證明可抑制大腸桿菌的细菌活性，而大腸桿菌是引致腹瀉的常見菌種，因此副乾酪乳桿菌被應用於治療腹瀉[27]。包含副乾酪乳桿菌的活菌製劑可與常規療法結合使用，以治療溃疡性结肠炎[24]。一項系統綜述為副乾酪乳桿菌LP-33菌株治療變應性鼻炎提供了有益的臨床和免疫學作用的重要證據。[28]

幽門螺旋桿菌感染

副乾酪乳桿菌顯示出對幽門螺旋桿菌的抑菌和殺菌活性。 [29]

大腸激躁症

副乾酪乳桿菌可減輕胃腸道症狀的嚴重程度，並改善某些大腸激躁症(IBS) 亞型個體的心理健康。 [30]

癌症

胃癌和結腸癌細胞的凋亡和生長易受已熱滅活和有活力的IMPC2.1菌株的影響[1]。

Health concerns

The manipulation of the gut microbiota is complex and may cause bacteria-host interactions. Although probiotics are considered safe, when they are used by oral administration there is a risk of passage of viable bacteria from the gastrointestinal tract to the internal organs (bacterial translocation) and subsequent bacteremia, which can cause adverse health consequences.[7] Some people, such as those with immune compromise, short bowel syndrome, central venous catheters, cardiac valve disease and premature infants, may be at higher risk for adverse events.[8]

Currently, the probiotic strain, frequency, dose and duration of the probiotic therapy are not established.[7] Live bacteria might not be essential because of beneficial effects of probiotics seems to be mediated by their DNA and by secreted soluble factors, and their therapeutic effects may be obtained by systemic administration rather than oral administration.[7][31]

歷史

乳酸菌（Lactic Acid Bacteria；一般縮寫作LAB）是在1900年代初進行分類和分組的。牠們受到注意，主要是由於科學家觀察到這些細菌在不同食品（尤其是乳製品）中的相互作用。1991年，荷蘭微生物學家马丁努斯·威廉·拜耶林克從之前已知的LAB組中分離出了革蘭氏陽性細菌，就是乳酸桿菌[32]。 副乾酪乳桿菌最近已被歸類為乾酪乳桿菌益生菌群組的成員[1]。但是，在生物分类学上，其具體位置並不明確。1996年，Dicks, Duplessis, Dellaglio & Lauer提出副乾酪乳桿菌 並不是一個獨立的物種[4]。

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外部連結

分類單元識別碼
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