CD29

CD29
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4WK4、3G9W、3T9K、3VI3、3VI4、4DX9、4WJK、4WK0、4WK2
識別號
别名	ITGB1；, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
外部ID	OMIM：135630 MGI：96610 HomoloGene：22999 GeneCards：ITGB1
基因位置（人类）
染色体	10號染色體
终止	33,005,792 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	129,459,681 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• virus receptor activity; • 金屬離子結合; • integrin binding; • 血浆蛋白结合; • laminin binding; • cell adhesion molecule binding; • collagen binding involved in cell-matrix adhesion; • coreceptor activity; • 蛋白酶結合; • fibronectin binding; • actin binding; • C-X3-C chemokine binding; • protein heterodimerization activity; • 大分子复合物结合; • cadherin binding; • signaling receptor activity;
細胞組分	• 細胞質; • 核内体; • 膜; • 黑色素体; • ruffle; • integrin alpha8-beta1 complex; • 突触; • ruffle membrane; • integrin complex; • 细胞质的核周区域; • cell projection; • 树突棘; • cell surface; • 分裂沟; • integrin alpha7-beta1 complex; • 外排體; • 板状伪足; • integral component of membrane; • recycling endosome; • integrin alpha1-beta1 complex; • 肌間盤; • 絲狀偽足; • 神经肌肉接点; • receptor complex; • 细胞膜; • integrin alpha11-beta1 complex; • myelin sheath abaxonal region; • synaptic membrane; • integrin alpha10-beta1 complex; • 细胞连接; • integrin alpha2-beta1 complex; • 肌膜; • external side of plasma membrane; • cytoplasmic vesicle; • integrin alpha3-beta1 complex; • 脂筏模型; • 粘着斑; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of synaptic membrane; • 大分子复合体;
生物學過程	• leukocyte cell-cell adhesion; • cell migration involved in sprouting angiogenesis; • stress fiber assembly; • 病毒进入; • B cell differentiation; • neuron projection development; • transforming growth factor beta receptor signaling pathway; • regulation of collagen catabolic process; • negative regulation of cell differentiation; • cardiac muscle cell differentiation; • cellular response to low-density lipoprotein particle stimulus; • in utero embryonic development; • cell-substrate adhesion; • positive regulation of GTPase activity; • regulation of immune response; • viral process; • dendrite morphogenesis; • cell fate specification; • G1期; • heterotypic cell-cell adhesion; • extracellular matrix organization; • cell-cell adhesion mediated by integrin; • cellular defense response; • 細胞粘附; • formation of radial glial scaffolds; • axon extension; • leukocyte tethering or rolling; • integrin-mediated signaling pathway; • cell-matrix adhesion; • sarcomere organization; • negative regulation of anoikis; • leukocyte migration; • homophilic cell adhesion via plasma membrane adhesion molecules; • visual learning; • calcium-independent cell-matrix adhesion; • cardiac muscle tissue development; • negative regulation of Rho protein signal transduction; • receptor internalization; • regulation of cell cycle; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • mesodermal cell differentiation; • 细胞迁移; • germ cell migration; • cell adhesion mediated by integrin; • basement membrane organization; • positive regulation of protein localization to plasma membrane; • G1/S transition of mitotic cell cycle; • 吞噬作用; • cytokine-mediated signaling pathway; • cell projection organization; • lamellipodium assembly; • positive regulation of angiogenesis; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • positive regulation of signaling receptor activity; • positive regulation of cell migration;
	Sources:Amigo / QuickGO
直系同源
	3688
	16412
	ENSG00000150093
	ENSMUSG00000025809
	P05556
	P09055
NM_002211; NM_033666; NM_033667; NM_033668; NM_033669;
	NM_133376
	NM_010578
	NP_002202; NP_391988; NP_596867
	NP_034708
	維基數據
檢視/編輯人類	檢視/編輯小鼠

整联蛋白β-1（英語：Integrin beta-1），也被称为 CD29 是一个由人类基因 ITGB1 编码的蛋白质^[5]。CD29是整合素极晚期抗原受体的一个亚基。它与α-3亚基形成整合素α3β1，作为神经生长因子1和络丝蛋白的受体。在心肌和骨骼肌种，整联蛋白β-1会选择性表达为β-1D蛋白质异形体。

相互作用[编辑]

CD29已经显示出与下列蛋白質交互作用：

参考文献[编辑]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.
^ Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.
^ Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.
^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.
^ Radford KJ, Thorne RF, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.
^ ^10.0 ^10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.
^ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
^ ^12.0 ^12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.
^ Loo DT, Kanner SB, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.
^ Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.
^ ^15.0 ^15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.
^ Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
^ Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.
^ Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.
^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.
^ Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.
^ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.
^ Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.
^ Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.
^ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.
^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.
^ Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.

外部链接[编辑]

醫學主題詞表（MeSH）：CD29+Antigen
Human ITGB1 genome location and ITGB1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2524991-5] Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991. doi:10.1111/j.1469-1809.1989.tb01118.x.

[6] Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. The Journal of Cell Biology. Aug 1990, 111 (2): 721–9. PMC 2116186 . PMID 2116421. doi:10.1083/jcb.111.2.721.

[7] Otey CA, Vasquez GB, Burridge K, Erickson BW. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. The Journal of Biological Chemistry. Oct 1993, 268 (28): 21193–7. PMID 7691808.

[pmid10741407-8] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. European Journal of Immunology. Mar 2000, 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X.

[pmid8630057-9] Radford KJ, Thorne RF, Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochemical and Biophysical Research Communications. May 1996, 222 (1): 13–8. PMID 8630057. doi:10.1006/bbrc.1996.0690.

[pmid12175627-10] 10.0 ^10.1 Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. Journal of Hepatology. Sep 2002, 37 (3): 322–30. PMID 12175627. doi:10.1016/S0168-8278(02)00175-7.

[pmid10906324-11] Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.

[pmid11807098-12] 12.0 ^12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.

[pmid9722563-13] Loo DT, Kanner SB, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. The Journal of Biological Chemistry. Sep 1998, 273 (36): 23304–12. PMID 9722563. doi:10.1074/jbc.273.36.23304.

[pmid10229664-14] Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. The Biochemical Journal. May 1999, 340 (Pt 1): 103–11. PMC 1220227 . PMID 10229664. doi:10.1042/0264-6021:3400103.

[pmid12435334-15] 15.0 ^15.1 Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society. Nov 2002, 10 (11): 890–7. PMID 12435334. doi:10.1053/joca.2002.0842.

[pmid9442085-16] Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.

[pmid9281591-17] Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.

[pmid11741908-18] Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. Mar 2002, 277 (10): 8140–5. PMID 11741908. doi:10.1074/jbc.M109031200.

[pmid10852818-19] Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.

[pmid11967148-20] Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Current Biology. Apr 2002, 12 (8): 622–31. PMID 11967148. doi:10.1016/S0960-9822(02)00764-9.

[pmid11919189-21] Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.

[pmid12138200-22] Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.

[23] Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.

[24] Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.

[pmid9360996-25] Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.

[pmid11313964-26] Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.

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