卡普韦林

卡普韦林
	IUPAC名; {5-[(3,5-Dichlorophenyl)sulfanyl]-4-(propan-2-yl)-1-[(pyridin-4-yl)methyl]-1H-imidazol-2-yl}methyl carbamate
识别
CAS号	178979-85-6
PubChem	1783
ChemSpider	1717
SMILES	O=C(OCc2nc(c(Sc1cc(Cl)cc(Cl)c1)n2Cc3ccncc3)C(C)C)N;
InChI	1/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27);
InChIKey	YQXCVAGCMNFUMQ-UHFFFAOYAP
性质
化学式	C20H20Cl2N4O2S
摩尔质量	451.37 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

卡普韦林（INN：Capravirine），或译卡拉韦林、卡帕韦林，是一种非核苷逆转录酶抑制剂，在辉瑞公司停止开发前已进入II期试验。^[1]^[2]进行的两项IIb期试验均未能证明卡普韦林治疗比现有的三药HIV疗法具有任何显着优势，并且药理学研究表明卡普韦林可能与其他HIV药物产生相互作用。^[3]^[4]

参考资料[编辑]

^ PubChem. Capravirine. pubchem.ncbi.nlm.nih.gov. [2019-06-02] （英语）.
^ Capravirine - Anti-Retroviral Drug. Drug Development Technology. [2019-06-02] （英国英语）.
^ Capravirine - Anti-Retroviral Drug. Drug Development Technology. [2019-06-02] （英国英语）.
^ A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. 23 June 2005 [2019-06-02] （英语）.

[1] PubChem. Capravirine. pubchem.ncbi.nlm.nih.gov. [2019-06-02] （英语）.

[2] Capravirine - Anti-Retroviral Drug. Drug Development Technology. [2019-06-02] （英国英语）.

[3] Capravirine - Anti-Retroviral Drug. Drug Development Technology. [2019-06-02] （英国英语）.

[4] A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. 23 June 2005 [2019-06-02] （英语）.

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