Ras超家族

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Hras surface colored by conservation.png
H-RasPDB121p上的结构,颜色代表了Pfam宗系上的氨基酸保守性数据,金色:最保守;深青色:最不保守
鉴定
标志 Ras
Pfam(蛋白家族查询站) PF00071
InterPro(蛋白数据整合站) IPR013753
PROSITE(蛋白数据站) PDOC00017
SCOP(蛋白结构分类数据站) 5p21
OPM蛋白(膜蛋白方向) 1uad
CDD(保守域数据站) cd00882

Ras超家族英语:Ras superfamily)是一个小GTP酶英语small GTPase蛋白质超家族英语protein superfamily,名称来自其中的Ras亚家族(在人类中为KRASNRASHRAS)。

Ras超家族中有超过100种蛋白质[1] ,根据其序列、结构和功能,可分为9个主要的家族,各自还可再分亚家族。这9个蛋白质家族为:RasRadRabRapRanRhoRhebRitArfMiro最近也被列入这个超家族中。

每个亚家族都有共同的G结构域核心,提供GTP酶与GTP/GDP交换活性。

The surrounding sequence helps determine the functional specificity of the small GTPase, for example the 'Insert Loop', common to the Rho subfamily, specifically contributes to binding to effector proteins such as IQGAP and WASP.

In general, the Ras family is responsible for cell proliferation: Rho for cell morphology, Ran for nuclear transport, and Rab and Arf for vesicle transport.[2]

亚家族与其成员[编辑]

以下列表列出了人类蛋白质中Ras超家族的成员[1]

亚家族 功能 成员
Ras 细胞增殖英语cell proliferation [2] DIRAS1; DIRAS2; DIRAS3; ERAS; GEM; HRAS; KRAS; MRAS; NKIRAS1; NKIRAS2; NRAS; RALA; RALB; RAP1A; RAP1B; RAP2A; RAP2B; RAP2C; RASD1; RASD2; RASL10A; RASL10B; RASL11A; RASL11B; RASL12; REM1; REM2; RERG; RERGL; RRAD; RRAS; RRAS2
Rho 细胞骨架的动力与形态[2] RHOA; RHOB; RHOBTB1; RHOBTB2; RHOBTB3; RHOC; RHOD; RHOF; RHOG; RHOH; RHOJ; RHOQ; RHOU; RHOV; RND1; RND2; RND3; RAC1; RAC2; RAC3; CDC42
Rab 膜转运 RAB1A; RAB1B; RAB2; RAB3A; RAB3B; RAB3C; RAB3D; RAB4A; RAB4B; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB6C; RAB7A; RAB7B; RAB7L1; RAB8A; RAB8B; RAB9; RAB9B; RABL2A; RABL2B; RABL4; RAB10; RAB11A; RAB11B; RAB12; RAB13; RAB14; RAB15; RAB17; RAB18; RAB19; RAB20; RAB21; RAB22A; RAB23; RAB24; RAB25; RAB26; RAB27A; RAB27B; RAB28; RAB2B; RAB30; RAB31; RAB32; RAB33A; RAB33B; RAB34; RAB35; RAB36; RAB37; RAB38; RAB39; RAB39B; RAB40A; RAB40AL; RAB40B; RAB40C; RAB41; RAB42; RAB43
Rap 细胞粘附英语cell adhesion RAP1A; RAP1B; RAP2A; RAP2B; RAP2C
Arf 囊泡转运英语Vesicular transport protein[2] ARF1; ARF3; ARF4; ARF5; ARF6; ARL1; ARL2; ARL3; ARL4; ARL5; ARL5C; ARL6; ARL7; ARL8; ARL9; ARL10A; ARL10B; ARL10C; ARL11; ARL13A; ARL13B; ARL14; ARL15; ARL16; ARL17; TRIM23, ARL4D; ARFRP1; ARL13B
Ran 核運輸 RAN
Rheb mTOR途径 RHEB; RHEBL1
RGK RRAD; GEM; REM; REM2
Rit RIT1; RIT2
Miro 线粒体转运 RHOT1; RHOT2

未分类:

参考文献[编辑]

  1. ^ 1.0 1.1 Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J. Cell. Sci. March 2005, 118 (Pt 5): 843–6. PMID 15731001. doi:10.1242/jcs.01660. 
  2. ^ 2.0 2.1 2.2 2.3 Munemitsu S, Innis M, Clark R, McCormick F, Ullrich A, Polakis P. Molecular cloning and experssion of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990, 10 (11): 5977–82. ISSN 0270-7306. PMC 361395. PMID 2122236.