香柑內酯

**香柑內酯**
臨床資料
給藥途徑	口服
ATC碼	D05BA03 (WHO) ;
法律規範狀態
法律規範	處方藥（℞-only）;
識別資訊
	IUPAC命名法 5-methoxy-2H-furo[3,2-g]chromen-2-one; ;
CAS號	484-20-8
PubChem CID	2355;
ChemSpider	2265 ;
UNII	4FVK84C92X;
KEGG	D07521 ;
ChEMBL	ChEMBL24171 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID1025560 ;
ECHA InfoCard	100.006.913
化學資訊
化學式	C12H8O4
摩爾質量	216.19 g/mol
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES O=C\1Oc3c(/C=C/1)c(OC)c2ccoc2c3;
	InChI InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3 ; Key:BGEBZHIAGXMEMV-UHFFFAOYSA-N ;

香柑內酯（5-甲氧補骨脂素）是一種存在於香檸檬精油與其他柑橘屬植物精油^[1]，以及葡萄柚汁中的呋喃香豆素（furanocoumarin），屬補骨脂素的衍生物。^[2] 它是香檸檬精油中引起光敏性（光毒性）的活性物質。^[3] 目前市面上的香水採用的是不含香柑內酯的香檸檬精油或人工合成的類似香味物質。

醫學上香柑內酯與長波紫外線（UVA）一同用於銀屑病的長波紫外線光化治療。^[4]^[5]

參考資料[編輯]

^ Calvarano I., Calvarano M., Gionfriddo F., Bovalo F., Postorino E. HPLC profile of citrus essential oils from different species and geographic origin. Essenze Derivati agrumari. 1995, 65: 488–502.
^ Sakamaki N., Nakazato M., Matsumoto H., Hagino K., Hirata K., Ushiyama H. Contents of furanocoumarins in grapefruit juice and health foods. Journal of the Food Hygienic Society of Japan. 2008, 49 (4): 326–331. PMID 18787320. doi:10.3358/shokueishi.49.326.
^ Francesco Gionfriddo, Enrico Postorino and Giuseppe Calabrò. Elimination of Furocoumarins in Bergamot Peel Oil. Perfumer & Flavorist. 2004, 29.
^ HONIGSMANN, HERBERT; JASCHKE, ERNA; GSCHNAIT, FRITZ; BRENNER, WILHELM; FRITSCH, PETER; WOLFF, KLAUS. 5-Methoxypsoralen (Bergapten) in photochemotherapy of psoriasis. British Journal of Dermatology (Wiley-Blackwell). 1979, 101 (4): 369–378. ISSN 0007-0963. doi:10.1111/j.1365-2133.1979.tb00014.x.
^ A. Tanew, B. Ortel, K. Rappersberger, H. Hönigsmann. 5-Methoxypsoralen (Bergapten) for photochemotherapy. Bioavailability, phototoxicity, and clinical efficacy in psoriasis of a new drug preparation. Journal of the American Academy of Dermatology. 1988-2, 18 (2 Pt 1): 333–338 [2019-05-25]. ISSN 0190-9622. PMID 3279089. 請檢查|date=中的日期值 (幫助)

[1] Calvarano I., Calvarano M., Gionfriddo F., Bovalo F., Postorino E. HPLC profile of citrus essential oils from different species and geographic origin. Essenze Derivati agrumari. 1995, 65: 488–502.

[2] Sakamaki N., Nakazato M., Matsumoto H., Hagino K., Hirata K., Ushiyama H. Contents of furanocoumarins in grapefruit juice and health foods. Journal of the Food Hygienic Society of Japan. 2008, 49 (4): 326–331. PMID 18787320. doi:10.3358/shokueishi.49.326.

[3] Francesco Gionfriddo, Enrico Postorino and Giuseppe Calabrò. Elimination of Furocoumarins in Bergamot Peel Oil. Perfumer & Flavorist. 2004, 29.

[4] HONIGSMANN, HERBERT; JASCHKE, ERNA; GSCHNAIT, FRITZ; BRENNER, WILHELM; FRITSCH, PETER; WOLFF, KLAUS. 5-Methoxypsoralen (Bergapten) in photochemotherapy of psoriasis. British Journal of Dermatology (Wiley-Blackwell). 1979, 101 (4): 369–378. ISSN 0007-0963. doi:10.1111/j.1365-2133.1979.tb00014.x.

[5] A. Tanew, B. Ortel, K. Rappersberger, H. Hönigsmann. 5-Methoxypsoralen (Bergapten) for photochemotherapy. Bioavailability, phototoxicity, and clinical efficacy in psoriasis of a new drug preparation. Journal of the American Academy of Dermatology. 1988-2, 18 (2 Pt 1): 333–338 [2019-05-25]. ISSN 0190-9622. PMID 3279089. 請檢查|date=中的日期值 (幫助)

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