CCL9

趨化因子（C-C基序）配體9; Chemokine (C-C motif) ligand 9
標識
代號	Ccl9; CCF18; MRP-2; Scya10; Scya9
擴展標識	鼠基因：104533 同源基因：86734 GeneCards: Ccl9 Gene
基因本體論描述
分子功能	· cytokine activity; · chemokine activity;
細胞成分	· extracellular region; · extracellular space;
生物過程	· chemotaxis; · immune response;
	Sources: Amigo / QuickGO
直系同源體
	閱; 論; 編;

CCL9（英語：Chemokine (C-C motif) ligand 9）是一個小型的細胞因子，屬於CC趨化因子家族。它的別名有巨噬細胞炎性蛋白-1γ（英語：macrophage inflammatory protein-1 gamma，MIP-1γ）, 巨噬細胞炎症蛋白相關蛋白-2（英語：macrophage inflammatory protein-related protein-2，MRP-2）以及在齧齒類中使用的CCF18。CCL9還曾經被定名為CCL10，但這個名稱已不再使用。

它由淋巴結相關上皮組織（FAE）分泌（如Peyer氏斑塊（英語：Peyer's patch）周圍），並影響擁有細胞表面分子CD11b與趨化因子受體 CCR1的樹突狀細胞^[1]。 CCL9 通過其受體CCR1（破骨細胞中最豐富的趨化因子受體）激活破骨細胞，表明了CCL9可能在骨質吸收（英語：bone resorption）中的重要作用^[2]。CCL9巨噬細胞和骨髓細胞里也持續表達^[3]^[4]。編碼CCL9的基因位於小鼠的11號染色體上^[4]。

參考文獻[編輯]

^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300.
^ Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319.
^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394.
^ ^4.0 ^4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.

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[1] Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300.

[2] Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319.

[3] Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394.

[hara-4] 4.0 ^4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.

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