VIS1 (英語:viral integration site 1 的縮寫,也稱為HIS-1 )是一個長鏈非編碼RNA 基因 [ 2] [ 3] ,在脊椎動物 中普遍存在[ 4] ,僅在上皮組織 中表達,和白血病 等癌 症的預後 有關[ 5] 。
^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Askew DS, Bartholomew C, Buchberg AM, et al. His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia . Oncogene. November 1991, 6 (11): 2041–2047. PMID 1682866 .
^ Askew DS, Li J, Ihle JN. Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame . Mol. Cell. Biol. March 1994, 14 (3): 1743–1751. PMC 358532 . PMID 8114708 . doi:10.1128/MCB.14.3.1743 .
^ Li J, Rhodes JC, Askew DS. Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene. Gene. January 1997, 184 (2): 169–176. PMID 9031624 . doi:10.1016/S0378-1119(96)00591-4 .
^ Li J, Witte DP, Van Dyke T, Askew DS. Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues . Am. J. Pathol. April 1997, 150 (4): 1297–1305. PMC 1858164 . PMID 9094986 .