傳染性軟疣病毒
外觀
傳染性軟疣病毒![]() | |
---|---|
![]() | |
電子顯微鏡下的傳染性軟疣病毒 | |
病毒分類 ![]() | |
(未分級): | 病毒 Virus |
域: | 多變DNA病毒域 Varidnaviria |
界: | 班福病毒界 Bamfordvirae |
門: | 核質病毒門 Nucleocytoviricota |
綱: | 痘疹病毒綱 Pokkesviricetes |
目: | 克希特恩病毒目 Chitovirales |
科: | 痘病毒科 Poxviridae |
屬: | 軟疣痘病毒屬 Molluscipoxvirus |
種: | 傳染性軟疣病毒 Molluscum contagiosum virus
|
傳染性軟疣病毒(MCV) 是痘病毒科的一種病毒,會使人類患上傳染性軟疣。傳染性軟疣病毒與痘病毒科的其他病毒有着複雜的結構,包括表面的膜,核心,以及側體。病毒可能以包涵體或出芽等形式在宿主細胞膜內部成熟,並在短時間內散發大量病毒。據測量,傳染性軟疣病毒的直徑約為200納米,長度約為320納米,高度則在100納米左右。[1]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Molluscum_contagiosum_high_mag.jpg/220px-Molluscum_contagiosum_high_mag.jpg)
臨床表現可用於診斷傳染性軟疣;傳染性軟疣病毒不能進行常規培養,手術活檢可進一步進行診斷。
傳染性軟疣病毒共有4種,分別是MCV-1型、MCV-2型、MCV-3型和MCV-4型。MCV-1型是人類感染最普遍的;MCV-2型常見於成人主要通過性傳播。[2][3][4] PCR技術可幫助確定並區分引起病變的是哪一種類型的MCV。[5][6][7]
基因組
[編輯]基因組為不分段的單分子線性雙鏈DNA,由180000–200000個核苷酸組成。不同核苷酸之間通過共價鍵連接兩端邊緣以及重複複雜的序列。其中有160個基因已被確定。[8]
動物病毒
[編輯]有一種動物病毒可以使馬和驢患上與傳染性軟疣類似的疾病。[9][10][11] DNA研究表明,該病毒與MCV是密切相關的。[12]
參考
[編輯]- ^ Büchen-Osmond, C. (Ed) (2003). 00.058.1.07.001. Molluscum contagiosum virus. In: ICTVdB - The Universal Virus Database, version 3. Büchen-Osmond, C. (Ed), ICTVdB Management, Columbia University, New York, USA
- ^ Porter CD, Muhlemann MF, Cream JJ, Archard LC. Molluscum contagiosum: characterization of viral DNA and clinical features. Epidemiol. Infect. 1987, 99 (2): 563–7. PMC 2249301
. PMID 2824227. doi:10.1017/S0950268800068072.
- ^ Yamashita H, Uemura T, Kawashima M. Molecular epidemiologic analysis of Japanese patients with molluscum contagiosum. Int. J. Dermatol. 1996, 35 (2): 99–105. PMID 8850036. doi:10.1111/j.1365-4362.1996.tb03270.x.
- ^ Agromayor M, Ortiz P, Lopez-Estebaranz JL, Gonzalez-Nicolas J, Esteban M, Martin-Gallardo A. Molecular epidemiology of molluscum contagiosum virus and analysis of the host-serum antibody response in Spanish HIV-negative patients. J. Med. Virol. 2002, 66 (2): 151–8. PMID 11782922. doi:10.1002/jmv.2124.
- ^ Nu?ez A, Funes JM, Agromayor M, et al. Detection and typing of molluscum contagiosum virus in skin lesions by using a simple lysis method and polymerase chain reaction. J. Med. Virol. 1996, 50 (4): 342–9. PMID 8950692. doi:10.1002/(SICI)1096-9071(199612)50:4<342::AID-JMV10>3.0.CO;2-K.
- ^ Thompson CH. Identification and typing of molluscum contagiosum virus in clinical specimens by polymerase chain reaction. J. Med. Virol. 1997, 53 (3): 205–11. PMID 9365883. doi:10.1002/(SICI)1096-9071(199711)53:3<205::AID-JMV4>3.0.CO;2-C.
- ^ Trama JP, Adelson ME, Mordechai E. Identification and genotyping of molluscum contagiosum virus from genital swab samples by real-time PCR and Pyrosequencing. J Clin Virol. 2007, 40 (4): 325–9. PMID 17997134. doi:10.1016/j.jcv.2007.09.007.
- ^ Thompson CH. Molluscum contagiosum: new perspectives on an old virus. Curr. Opin. Infect. Dis. 1999, 12 (3): 185–9. PMID 17035777. doi:10.1097/00001432-199906000-00005.
- ^ Van Rensburg IB, Collett MG, Ronen N, Gerdes T (1991) Molluscum contagiosum in a horse. J S Afr Vet Assoc 62(2):72-74
- ^ Lange L, Marett S, Maree C, Gerdes T (1991) Molluscum contagiosum in three horses. J S Afr Vet Assoc 62(2):68-71
- ^ Cooley AJ, Reinhard MK, Gross TL, Fadok VA, Levy M (1987) Molluscum contagiosum in a horse with granulomatous enteritis. J Comp Pathol 97(1):29-34
- ^ Thompson CH, Yager JA, Van Rensburg IB (1998) Close relationship between equine and human molluscum contagiosum virus demonstrated by in situ hybridisation. Res Vet Sci 64(2):157-161
外部連結
[編輯]
|
|