CCL12

趨化因子（C-C基序）配體12
Chemokine (C-C motif) ligand 12
趨化因子（C-C基序）配體12; Chemokine (C-C motif) ligand 12
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 3IFD
標識
代號	Ccl12; MCP-5; Scya12
擴展標識	遺傳學：158105 同源基因：2245 GeneCards: Ccl12 Gene
基因本體論描述
分子功能	· cytokine activity; · chemokine activity; · CCR2 chemokine receptor binding;
細胞成分	· extracellular region; · extracellular space;
生物過程	· angiogenesis; · monocyte chemotaxis; · chemotaxis; · inflammatory response; · immune response;
	Sources: Amigo / QuickGO
直系同源體
物種	人類
Entrez	20293
Ensembl	ENSMUSG00000035352
UniProt	Q62401
mRNA序列	NM_011331
蛋白序列	NP_035461
基因位置	Chr 11:; 82.1 – 82.1 Mb
PubMed查詢	[1]
	閱; 論; 編;

CCL12（英語：Chemokine (C-C motif) ligand 12）是一個小型的細胞因子，屬於CC趨化因子家族，最早在鼠類中發現。它還被叫做單核細胞趨化蛋白5（英語：monocyte chemotactic protein 5，MCP-5），又由於其和人類趨化因子MCP-1的相似性，有時候也被稱為MCP-1相關趨化因子（英語：MCP-1-related chemokine）。CCL12特異性影響嗜酸性粒細胞、單核細胞和淋巴細胞^[1]。這個趨化因子正常情況下存在於淋巴結和胸腺中，其表達能顯著誘導巨噬細胞^[1]^[2]。編碼CCL12的基因發現於小鼠染色體11上^[2]。

參考文獻

^ ^1.0 ^1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.
^ ^2.0 ^2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.

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[jia-1] 1.0 ^1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.

[sarafi-2] 2.0 ^2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.

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