4-羥基雌酮
外觀
4-羥基雌酮 | |
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IUPAC名 (8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one | |
別名 | 4-OHE1; Estra-1,3,5(10)-triene-3,4-diol-17-one; 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one |
識別 | |
CAS號 | 3131-23-5 ![]() |
PubChem | 9971251 |
ChemSpider | 8146843 |
SMILES |
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ChEBI | 87602 |
性質 | |
化學式 | C18H22O3 |
摩爾質量 | 286.37 g·mol−1 |
熔點 | 260—265 °C(533—538 K)[1] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
4-羥基雌酮(英語:4-Hydroxyestrone,縮寫4-OHE1,或稱為「雌甾-1,3,5(10)-三烯-3,4-二醇-17-酮」,estra-1,3,5(10)-trien-3,4-diol-17-one)是一種天然內源性的兒茶酚雌激素和雌酮與雌二醇的次要代謝產物[2][3][4]。它具有微量的雌激素活性,與2-羥基雌二醇、16α-羥基雌酮、雌三醇(16α-羥基雌二醇)和4-羥基雌二醇等其它羥基雌二醇類似,但不同於2-羥基雌酮[2][5]。
參考資料
[編輯]- ^ Jack Fishman, Maria Tomasz, Rosemarie Lehman. Catechol Derivatives of Estrogens 1. The Journal of Organic Chemistry. 1960-04, 25 (4): 585–588 [2021-01-27]. ISSN 0022-3263. doi:10.1021/jo01074a026 (英語).
- ^ 2.0 2.1 Oettel M, Schillinger E. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.
- ^ Rakel D. Integrative Medicine. Elsevier Health Sciences. 2012: 338–. ISBN 978-1-4377-1793-8.
- ^ Buchsbaum HJ. The Menopause. Springer Science & Business Media. 6 December 2012: 64–65. ISBN 978-1-4612-5525-3.
- ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.
外部連結
[編輯]
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