CD6

CD6
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	5A2E
識別號
别名	CD6；, TP120, CD6 molecule
外部ID	OMIM：186720 MGI：103566 HomoloGene：4893 GeneCards：CD6
相關疾病
	多发性硬化症
基因位置（人类）
染色体	11號染色體
终止	61,020,377 bp
基因位置（小鼠）
染色体	小鼠19号染色体
终止	10,807,422 bp
基因本體
分子功能	• lipopolysaccharide binding; • lipoteichoic acid binding; • scavenger receptor activity; • 血浆蛋白结合; • 相同蛋白质结合;
細胞組分	• integral component of membrane; • 膜; • intrinsic component of plasma membrane; • 细胞膜; • integral component of plasma membrane; • T cell receptor complex; • 細胞外區域; • 免疫突触; • external side of plasma membrane;
生物學過程	• positive regulation of cytokine production involved in inflammatory response; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • adaptive immune response; • immune system process; • acute inflammatory response to antigenic stimulus; • 受体介导的内吞作用; • response to lipopolysaccharide; • 細胞粘附; • positive regulation of T cell proliferation; • 先天免疫系統; • immunological synapse formation; • lipopolysaccharide-mediated signaling pathway; • vesicle-mediated transport; • 內吞作用;
	Sources:Amigo / QuickGO
直系同源
	923
	12511
	ENSG00000013725
	ENSMUSG00000024670
	P30203
	Q61003
	NM_001254750; NM_001254751; NM_006725
	NM_001037801; NM_009852
	NP_001241679; NP_001241680; NP_006716
	NP_001032890; NP_033982
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CD6（cluster of differentiation 6，分化簇6）是一种细胞表面蛋白质，由人类基因 CD6 编码^[6]，主要在T淋巴细胞等免疫细胞上表达^[7]。

参考文献[编辑]

^ 與CD6相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: CD6 CD6 molecule.
^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 1995, 181 (6): 2213–20. PMC 2192054 . PMID 7760007. doi:10.1084/jem.181.6.2213.

外部链接[编辑]

醫學主題詞表（MeSH）：CD6+protein,+human
Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
PDB中UniProt可用的所有結構信息之概述：P30203 (Human T-cell differentiation antigen CD6) 在PDBe-KB（英语：PDBe-KB）。

CD6引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[1] 與CD6相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-6] Entrez Gene: CD6 CD6 molecule.

[pmid7760007-7] Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 1995, 181 (6): 2213–20. PMC 2192054 . PMID 7760007. doi:10.1084/jem.181.6.2213.

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