CD1a （C luster of D ifferentiation 1a ）是身上的一種人類蛋白质 ，由基因「CD1A [3]
該蛋白屬於CD1蛋白家族 ，為一種穿膜醣蛋白。CD1a與β2-微球蛋白 共同構成的異源二聚體（heterodimers）稱為「CD1a複合體」（CD1a complex），在結構上類似MHC I分子 。兩者都具有抗原呈現 的能力，但CD1a主要呈現的是糖脂類 ，而MHC分子主要呈現的是多肽類 。人類身上的CD1家族基因共有五個，且都集中排列在1號染色體 上的某個區域[3]
臨床意義 [ 编辑 ] 在抽菸的病人身上，「CD1A 」在肺間質的表現會較為顯著[4]
參考文獻 [ 编辑 ]
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158477 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ 3.0 3.1 Entrez Gene: CD1A CD1a molecule . ^ Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F. Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients . Scientific Reports. September 2019, 9 (1): 13039. Bibcode:2019NatSR...913039P PMC 6736939 PMID 31506599 doi:10.1038/s41598-019-49648-2
外部連結 [ 编辑 ] 延伸閱讀 [ 编辑 ]
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CD1A 引用了美国国家医学图书馆 提供的資料，这些資料属于公共领域 。
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. PMID 31506599. doi:10.1038/s41598-019-49648-2.
