CD1a （C luster of D ifferentiation 1a ）是身上的一种人类蛋白质 ，由基因“CD1A [3]
该蛋白属于CD1蛋白家族 ，为一种穿膜糖蛋白。CD1a与β2-微球蛋白 共同构成的异源二聚体（heterodimers）称为“CD1a复合体”（CD1a complex），在结构上类似MHC I分子 。两者都具有抗原呈现 的能力，但CD1a主要呈现的是糖脂类 ，而MHC分子主要呈现的是多肽类 。人类身上的CD1家族基因共有五个，且都集中排列在1号染色体 上的某个区域[3]
临床意义 [ 编辑 ] 在抽烟的病人身上，“CD1A ”在肺间质的表现会较为显著[4]
参考文献 [ 编辑 ]
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158477 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ 3.0 3.1 Entrez Gene: CD1A CD1a molecule . ^ Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F. Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients . Scientific Reports. September 2019, 9 (1): 13039. Bibcode:2019NatSR...913039P PMC 6736939 PMID 31506599 doi:10.1038/s41598-019-49648-2
外部链接 [ 编辑 ] 延伸阅读 [ 编辑 ]
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CD1A 引用了美国国家医学图书馆 提供的资料，这些资料属于公共领域 。
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. PMID 31506599. doi:10.1038/s41598-019-49648-2.
