二肽基肽酶-4

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Dipeptidyl-peptidase 4
人类DPP-4的带状结构图
来自PDB 1PFQ.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 DPP4; ADABP; ADCP2; CD26; DPPIV; TP103
扩展标识 遗传学102720 鼠基因94919 同源基因3279 ChEMBL英语ChEMBL: 284 GeneCards: DPP4 Gene
EC編號 3.4.14.5
RNA表达模式
PBB GE DPP4 203717 at tn.png
PBB GE DPP4 203716 s at tn.png
PBB GE DPP4 211478 s at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 1803 13482
Ensembl ENSG00000197635 ENSMUSG00000035000
UniProt P27487 P28843
mRNA序列 NM_001935 NM_001159543
蛋白序列 NP_001926 NP_001153015
基因位置 Chr 2:
161.99 – 162.07 Mb
Chr 2:
62.33 – 62.41 Mb
PubMed查询 [1] [2]

二肽基肽酶-4(英语:Dipeptidyl peptidase-4 (DPP4),是一种人类体内的蛋白质,由DPPP4基因编码。[1] DPP4与ATRNFAPDPP8DPP9有关联。


引用[编辑]

  1. ^ Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. Jul 1993, 261 (5120): 466–9. PMID 8101391. doi:10.1126/science.8101391. 

延伸閱讀[编辑]

  • Ansorge S, Bühling F, Kähne T, Lendeckel U, Reinhold D, Täger M, Wrenger S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in Experimental Medicine and Biology. 1997, 421: 127–40. PMID 9330689. doi:10.1007/978-1-4757-9613-1_17. 
  • Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 2003, 383 (7-8): 1133–8. PMID 12437097. doi:10.1515/BC.2002.123. 
  • Sato K, Dang NH. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). International Journal of Oncology. Mar 2003, 22 (3): 481–97. PMID 12579300. 
  • de Meester I, Lambeir AM, Proost P, Scharpé S. Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 2003, 524: 3–17. ISBN 0-306-47717-3. PMID 12675218. doi:10.1007/0-306-47920-6_1. 
  • Koch S, Anthonsen D, Skovbjerg H, Sjöström H. On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 2003, 524: 181–7. ISBN 0-306-47717-3. PMID 12675238. doi:10.1007/0-306-47920-6_22. 
  • Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer. Histology and Histopathology. Oct 2004, 19 (4): 1345–51. PMID 15375776. 

外部連結[编辑]

Template:Clusters of differentiation by lineage