VCAM-1
VCAM-1（Vascular cell adhesion protein 1（I型血管细胞黏附蛋白）），又称CD106，是一种细胞黏附蛋白，在人体内由VCAM-1基因编码，属于一种唾液酸糖蛋白[5]。
结构
[编辑]VCAM-1含有6个或7个免疫球蛋白结构域，属于免疫球蛋白蛋白超家族（IgSF）。于人体内存在两个由可变剪接产生的转录本[6]。
功能与分布
[编辑]VCAM-1参与淋巴细胞—内皮细胞间黏附过程和细胞间信号识别过程，能在免疫应答中促进淋巴细胞向炎症区迁移[7]。淋巴细胞、软骨细胞等细胞中都含有VCAM-1，血管内皮细胞在受到细胞因子刺激后也会表达VCAM-1蛋白[6][8]。一些间充质干细胞亚群细胞表面表达CD106（VCAM-1）[9]。
参考
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000162692 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000027962 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T. The human VCAM1 gene is assigned to chromosome 1p31-p32. Cytogenet. Cell Genet. 1991, 58: 1852. doi:10.1159/000133735.
- ^ 6.0 6.1 Entrez Gene: VCAM1 vascular cell adhesion molecule 1.
- ^ VCAM1. Uniprot. [2018-01-10]. （原始内容存档于2017-10-03）.
- ^ Kienzle G.; von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum. 1998 Jul;41(7):1296-305.
- ^ ZX Yang; et al. CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties. PLoS One. 2013;8(3):e59354.