凝血酶
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凝血酶（英语：Thrombin，EC 3.4.21.5）是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质，在人体中被F2基因所编码[2][3]。在凝血作用第一级级联反应中，凝血酶原（凝血因子Ⅱ）被蛋白水解性切除以生成凝血酶，级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纤维蛋白原转变为不溶性的纤维蛋白，同时催化其他许多与凝血相关的反应。
另见
[编辑]参考文献
[编辑]- ^ PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v.
- ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211.
- ^ Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033.
深入阅读
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外部链接
[编辑]- The MEROPS online database for peptidases and their inhibitors: S01.217（页面存档备份，存于互联网档案馆）
- GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia（页面存档备份，存于互联网档案馆）
- [3]（页面存档备份，存于互联网档案馆） Anti-coagulation & proteases by The Proteolysis Map-animation
- [4] PMAP: The Proteolysis Map/Thrombin