二肽基肽酶-4：修订间差异

Dipeptidyl-peptidase 4
	人类DPP-4的带状结构图; 来自PDB 1PFQ.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1J2E, 1N1M, 1NU6, 1NU8, 1PFQ, 1R9M, 1R9N, 1RWQ, 1TK3, 1TKR, 1U8E, 1W1I, 1WCY, 1X70, 2AJL, 2BGN, 2BGR, 2BUB, 2FJP, 2G5P, 2G5T, 2G63, 2HHA, 2I03, 2I78, 2IIT, 2IIV, 2JID, 2OAG, 2OGZ, 2OLE, 2ONC, 2OPH, 2OQI, 2OQV, 2P8S, 2QJR, 2QKY, 2QOE, 2QT9, 2QTB, 2RGU, 2RIP, 3BJM, 3C43, 3C45, 3CCB, 3CCC, 3D4L, 3EIO, 3F8S, 3G0B, 3G0C, 3G0D, 3G0G, 3H0C, 3HAB, 3HAC, 3KWF, 3KWJ, 3NOX, 3O95, 3O9V, 3OC0, 3OPM, 3Q0T, 3Q8W, 3QBJ, 3SWW, 3SX4, 3VJK, 3VJL, 3VJM, 3W2T, 4A5S, 4DSA, 4DSZ, 4DTC, 4G1F, 4J3J, 4JH0, 4KR0, 4L72, 4LKO, 4N8D, 4N8E, 4PNZ, 4PV7, 4QZV
标识
代号	DPP4; ADABP; ADCP2; CD26; DPPIV; TP103
扩展标识	遗传学：102720 鼠基因：94919 同源基因：3279 ChEMBL: 284 GeneCards: DPP4 Gene
EC編號	3.4.14.5
基因本体论描述
分子功能	· virus receptor activity; · protease binding; · serine-type endopeptidase activity; · receptor binding; · protein binding; · serine-type peptidase activity; · dipeptidyl-peptidase activity; · identical protein binding; · protein homodimerization activity;
细胞成分	· lysosomal membrane; · plasma membrane; · focal adhesion; · cell surface; · membrane; · integral component of membrane; · apical plasma membrane; · lamellipodium; · endocytic vesicle; · lamellipodium membrane; · membrane raft; · intercellular canaliculus; · extracellular exosome; · invadopodium membrane;
生物过程	· behavioral fear response; · response to hypoxia; · proteolysis; · positive regulation of cell proliferation; · negative regulation of extracellular matrix disassembly; · T cell costimulation; · regulation of cell-cell adhesion mediated by integrin; · locomotory exploration behavior; · psychomotor behavior; · T cell activation; · endothelial cell migration; · viral entry into host cell;
	Sources: Amigo / QuickGO
RNA表达模式
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直系同源体
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2016年3月4日 (五) 23:31的版本

二肽基肽酶-4（英語：Dipeptidyl peptidase-4） (DPP4)，是一种人类体内的蛋白质，由DPPP4基因编码。^[1] DPP4与ATRN、FAP、DPP8和DPP9有关联。

引用

^ Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. Jul 1993, 261 (5120): 466–9. PMID 8101391. doi:10.1126/science.8101391.

延伸閱讀

Ansorge S, Bühling F, Kähne T, Lendeckel U, Reinhold D, Täger M, Wrenger S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in Experimental Medicine and Biology. 1997, 421: 127–40. PMID 9330689. doi:10.1007/978-1-4757-9613-1_17.
Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 2003, 383 (7-8): 1133–8. PMID 12437097. doi:10.1515/BC.2002.123.
Sato K, Dang NH. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). International Journal of Oncology. Mar 2003, 22 (3): 481–97. PMID 12579300.
de Meester I, Lambeir AM, Proost P, Scharpé S. Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 2003, 524: 3–17. ISBN 0-306-47717-3. PMID 12675218. doi:10.1007/0-306-47920-6_1.
Koch S, Anthonsen D, Skovbjerg H, Sjöström H. On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 2003, 524: 181–7. ISBN 0-306-47717-3. PMID 12675238. doi:10.1007/0-306-47920-6_22.
Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer. Histology and Histopathology. Oct 2004, 19 (4): 1345–51. PMID 15375776.

外部鏈接

The MEROPS online database for peptidases and their inhibitors: S09.003
醫學主題詞表（MeSH）：Dipeptidyl-Peptidase+IV
Banting and Best Diabetes Centre at UT dpp4

这是一篇與生物化學相關的小作品。你可以通过编辑或修订扩充其内容。

[pmid8101391-1] Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. Jul 1993, 261 (5120): 466–9. PMID 8101391. doi:10.1126/science.8101391.

[1]

@@ 第2行： / 第2行： @@
 {{refimprove|time=2015-09-18T13:31:32+00:00}}
 {{PBB|geneid=1803}}
 '''二肽基肽酶-4（{{lang-en|Dipeptidyl peptidase-4}}）''' ('''DPP4''')，是一种人类体内的蛋白质，由''DPPP4''[[基因]]编码。<ref name="pmid8101391">{{cite journal | vauthors = Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C | title = Direct association of adenosine deaminase with a T cell activation antigen, CD26 | journal = Science | volume = 261 | issue = 5120 | pages = 466–9 | date = Jul 1993 | pmid = 8101391 | doi = 10.1126/science.8101391 }}</ref> DPP4与[[ATRN]]、[[FAP]]、[[DPP8]]和[[DPP9]]有关联。
@@ 第7行： / 第8行： @@
 ==引用==
 {{reflist}}
+== 延伸閱讀 ==
+{{refbegin | 2}}
+* {{cite journal | vauthors = Ansorge S, Bühling F, Kähne T, Lendeckel U, Reinhold D, Täger M, Wrenger S | title = CD26/dipeptidyl peptidase IV in lymphocyte growth regulation | journal = Advances in Experimental Medicine and Biology | volume = 421 | issue =  | pages = 127–40 | year = 1997 | pmid = 9330689 | doi = 10.1007/978-1-4757-9613-1_17 }}
+* {{cite journal | vauthors = Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S | title = The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity | journal = Biological Chemistry | volume = 383 | issue = 7-8 | pages = 1133–8 | year = 2003 | pmid = 12437097 | doi = 10.1515/BC.2002.123 }}
+* {{cite journal | vauthors = Sato K, Dang NH | title = CD26: a novel treatment target for T-cell lymphoid malignancies? (Review) | journal = International Journal of Oncology | volume = 22 | issue = 3 | pages = 481–97 | date = Mar 2003 | pmid = 12579300 | doi =  }}
+* {{cite journal | vauthors = de Meester I, Lambeir AM, Proost P, Scharpé S | title = Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV | journal = Advances in Experimental Medicine and Biology | volume = 524 | issue =  | pages = 3–17 | year = 2003 | pmid = 12675218 | doi = 10.1007/0-306-47920-6_1 | isbn = 0-306-47717-3 | series = Advances in Experimental Medicine and Biology }}
+* {{cite journal | vauthors = Koch S, Anthonsen D, Skovbjerg H, Sjöström H | title = On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease | journal = Advances in Experimental Medicine and Biology | volume = 524 | issue =  | pages = 181–7 | year = 2003 | pmid = 12675238 | doi = 10.1007/0-306-47920-6_22 | isbn = 0-306-47717-3 | series = Advances in Experimental Medicine and Biology }}
+* {{cite journal | vauthors = Pro B, Dang NH | title = CD26/dipeptidyl peptidase IV and its role in cancer | journal = Histology and Histopathology | volume = 19 | issue = 4 | pages = 1345–51 | date = Oct 2004 | pmid = 15375776 | doi =  }}
+{{refend}}
+== 外部鏈接==
+* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=S09.003 S09.003]
+* {{MeshName|Dipeptidyl-Peptidase+IV}}
+* {{UTGlucagon|dpp4}}
 {{PDB Gallery|geneid=1803}}
 {{Clusters of differentiation}}
 {{Proteases}}
 {{生物化学小作品}}
 [[Category:肽酶]]