组织蛋白酶F：修订间差异

组织蛋白酶F
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1M6D
識別號
别名	CTSF；, CATSF, CLN13, cathepsin F
外部ID	OMIM：603539 MGI：1861434 HomoloGene：31194 GeneCards：CTSF
相關疾病
	neuronal ceroid lipofuscinosis 13、adult neuronal ceroid lipofuscinosis
基因位置（人类）
染色体	11號染色體
终止	66,568,879 bp
基因位置（小鼠）
染色体	小鼠19号染色体
终止	4,910,946 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 肽酶活性; • 半胱氨酸型肽酶活性; • 水解酶活性; • cysteine-type endopeptidase activity;
細胞組分	• 細胞外囊泡; • 溶酶体; • lysosomal lumen; • 外排體; • 細胞外空間; • collagen-containing extracellular matrix;
生物學過程	• proteolysis involved in cellular protein catabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • 蛋白酶解;
	Sources:Amigo / QuickGO
直系同源
	8722
	56464
	ENSG00000174080
	ENSMUSG00000083282
	Q9UBX1
	Q9R013
	NM_003793
	NM_019861
	NP_003784
	NP_063914
	維基數據
檢視/編輯人類	檢視/編輯小鼠

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行内

2022年10月26日 (三) 06:19的版本

组织蛋白酶F（学名：Cathepsin F）是一种在人体中由CTSF基因编码的蛋白质。^[6]^[7]^[8]

泰国肝吸虫的免疫诊断

组织蛋白酶F在虾夷盘扇贝中的表达

参考文献

^ 與组织蛋白酶F相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174080 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000083282 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. Dec 1998, 273 (48): 32000–8. PMID 9822672. doi:10.1074/jbc.273.48.32000 .
^ Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. Jun 1999, 274 (20): 13800–9. PMID 10318784. doi:10.1074/jbc.274.20.13800 .
^ Entrez Gene: CTSF cathepsin F.

拓展阅读

Nägler DK, Sulea T, Ménard R. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.. Biochem. Biophys. Res. Commun. 1999, 257 (2): 313–8. PMID 10198209. doi:10.1006/bbrc.1999.0461.
Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
Wex T, Wex H, Brömme D. The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene.. Biol. Chem. 2000, 380 (12): 1439–42. PMID 10661872. S2CID 28469574. doi:10.1515/BC.1999.185.
Shi GP, Bryant RA, Riese R, et al. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.. J. Exp. Med. 2000, 191 (7): 1177–86. PMC 2193169 . PMID 10748235. doi:10.1084/jem.191.7.1177.
Deussing J, Tisljar K, Papazoglou A, Peters C. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene.. Gene. 2000, 251 (2): 165–73. PMID 10876093. doi:10.1016/S0378-1119(00)00196-7.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Oörni K, Sneck M, Brömme D, et al. Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.. J. Biol. Chem. 2004, 279 (33): 34776–84. PMID 15184381. doi:10.1074/jbc.M310814200 .
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, et al. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer.. BMC Cancer. 2006, 5 (1): 68. PMC 1175083 . PMID 15989693. doi:10.1186/1471-2407-5-68.
Kaakinen R, Lindstedt KA, Sneck M, et al. Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.. Atherosclerosis. 2007, 192 (2): 323–7. PMID 16963053. doi:10.1016/j.atherosclerosis.2006.08.001.

外部链接

The MEROPS online database for peptidases and their inhibitors: C01.018

[1] 與组织蛋白酶F相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174080 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000083282 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9822672-6] Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. Dec 1998, 273 (48): 32000–8. PMID 9822672. doi:10.1074/jbc.273.48.32000 .

[pmid10318784-7] Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. Jun 1999, 274 (20): 13800–9. PMID 10318784. doi:10.1074/jbc.274.20.13800 .

[entrez-8] Entrez Gene: CTSF cathepsin F.

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