多巴胺轉運體

多巴胺轉運體
識別號
別名	SLC6A3；, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
外部ID	OMIM：126455 MGI：94862 HomoloGene：55547 GeneCards：SLC6A3
相關疾病
	infantile parkinsonism-dystonia、物質使用疾患
為以下藥物的標靶
	阿托莫西汀、丁氨苯丙酮、氯米帕明、去甲文拉法辛、右旋安非他命、右旋哌甲酯、gbr-12935、左旋米那普倫、馬吲哚、哌甲酯、(RS)-nomifensine、苯乙肼、西布曲明、曲米帕明、WIN35428、serdexmethylphenidate chloride、右旋哌甲酯、右旋安非他命、苯丙胺、liafensine、甲基苯丙胺、安非拉酮、馬吲哚、methylphenidate hydrochloride、dasotraline、diethylpropion hydrochloride、phenmetrazine hydrochloride
基因位置（人類）
染色體	5號染色體
終止	1,445,440 bp
基因位置（小鼠）
染色體	小鼠13號染色體
終止	73,726,791 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• protein N-terminus binding; • dopamine:sodium symporter activity; • 金屬離子結合; • neurotransmitter:sodium symporter activity; • dopamine binding; • 血漿蛋白結合; • symporter activity; • monoamine transmembrane transporter activity; • 大分子複合物結合; • 蛋白酶結合; • signaling receptor binding; • protein phosphatase 2A binding;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 細胞膜; • integral component of plasma membrane; • cell surface; • 軸突; • flotillin complex; • neuronal cell body; • 脂筏模型; • presynapse; • neuron projection; • dopaminergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
生物學過程	• response to cocaine; • 前脈衝抑制; • response to organic cyclic compound; • locomotory behavior; • dopamine biosynthetic process; • response to nicotine; • 老化; • neurotransmitter biosynthetic process; • monoamine transport; • adenohypophysis development; • regulation of dopamine metabolic process; • response to iron ion; • sensory perception of smell; • dopamine uptake involved in synaptic transmission; • dopamine catabolic process; • dopamine transport; • positive regulation of multicellular organism growth; • response to cAMP; • 哺乳; • response to ethanol; • neurotransmitter transport; • dopamine uptake; • transmembrane transport; • neurotransmitter uptake;
	Sources:Amigo / QuickGO
直系同源
	6531
	13162
	ENSG00000142319; ENSG00000276996
	ENSMUSG00000021609
	Q01959
	Q61327
	NM_001044
	NM_010020
	NP_001035
	NP_034150
	維基數據
檢視/編輯人類	檢視/編輯小鼠

多巴胺轉運體（英語：Dopamine transporter，DAT；溶質載體家族6成員3（英語：solute carrier family 6 member 3，SLC6A3））是負責將神經遞質從突觸間隙運輸回細胞質基質的跨膜蛋白。由多巴胺轉運體進行的再攝取是將多巴胺從突觸間隙清除的主要機制，除了前額葉，在前額葉多巴胺由去甲腎上腺素轉運體回收^[7]。

DAT與一些多巴胺相關的疾病有關, 包含注意力不足過動症、躁鬱症、重性抑鬱障礙、酗酒。編碼 DAT 蛋白的基因位於人類第5號染色體，含有15個外顯子，共64kbp長。

功能[編輯]

DAT從突觸間隙（英語：synaptic cleft）移除多巴胺，運回細胞內而終止神經遞質的信號。它屬於一種integral membrane protein（英語：integral membrane protein）^[8]。

參見[編輯]

單胺轉運體（英語：Monoamine transporter）
去甲腎上腺素轉運體
血清素轉運體
Glutamate transporter（英語：Glutamate transporter）

參考資料[編輯]

^ 與多巴胺轉運體相關的疾病；在維基數據上查看/編輯參考.
^ 對多巴胺轉運體起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carboni E, Tanda GL, Frau R, Di Chiara G. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.
^ Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.

外部連結[編輯]

[1] 與多巴胺轉運體相關的疾病；在維基數據上查看/編輯參考.

[2] 對多巴胺轉運體起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000142319、ENSG00000276996 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000021609 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2117046-7] Carboni E, Tanda GL, Frau R, Di Chiara G. Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals. J. Neurochem. 1990, 55 (3): 1067–70. PMID 2117046. doi:10.1111/j.1471-4159.1990.tb04599.x.

[Schultz-8] Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 1998, 80 (1): 1–27. PMID 9658025.

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