撲滅寧 - 維基百科，自由的百科全書

撲滅寧

IUPAC名 3-(3,5-dichlorophenyl)-1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione 3-(3,5-二氯苯基)-1,5-二甲基-3-氮雜雙環[3.1.0]己烷-2,4-二酮
識別
CAS號	32809-16-8 ^Y
PubChem	36242
ChemSpider	33326
SMILES	Clc1cc(cc(Cl)c1)N2C(=O)C3(C)CC3(C)C2=O
KEGG	C10986
性質
化學式	C₁₃H₁₁Cl₂NO₂
摩爾質量	284.14 g·mol⁻¹
若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

撲滅寧（英語：Procymidone）是一種農藥。它通常用於殺死不需要的蕨類植物和蕁麻，以及作為殺滅真菌的二甲醯亞胺殺菌劑，例如用作羽扇豆、葡萄、核果、草莓的拌種、收穫前噴灑或收穫後浸漬。^[1]它是一種已知的內分泌干擾物，可干擾雄性大鼠的性別分化。^[2]它被認為是一種毒藥。^[3]

參見[編輯]

參考資料[編輯]

^ Australian Pesticides and Veterinary Medicine Authority. Chemical Review Program/Procymidone. [9 February 2012]. （原始內容存檔於26 January 2012）.
^ Ostby J, Kelce WR, Lambright C, Wolf CJ, Mann P, Gray LE. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Toxicol Ind Health. 1999, 15 (1–2): 80–93. PMID 10188193. doi:10.1191/074823399678846718.
^ Australian Pesticides and Veterinary Medicine Authority, Chemical Review Program. procymidone_poster.pdf (PDF). [9 February 2012]. （原始內容 (PDF)存檔於27 February 2012）.

外部連結[編輯]

撲滅寧 in the Pesticide Properties DataBase (PPDB)

雄激素

受體

AR (A, B)

注意：此處包括了那些只有微弱男性化效應（或抗男性化（如氧雄龍））的蛋白同化甾類（因為它們合成代謝效應也是通過激活雄激素受體而是顯得）。

酶
(抑制劑)

20,22-碳鏈裂解酶	22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Mitotane Trilostane

17α-羥化酶， 17,20-裂合酶	22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone acetate Danazol Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Levonorgestrel Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 TGF-β Tioconazole Troglitazone VN/87-1 YM116

3β-HSD (I, II)	4-MA 阿扎斯丁腈酮達那唑環氧司坦金雀異黃素孕三烯酮左炔諾孕酮美替拉酮羥甲吡格列酮羅格列酮曲洛斯坦曲格列酮

17β-HSD (I-XIV)	Danazol Simvastatin

5α還原酶 (I, II)	22-Oxime Alfatradiol Azelaic acid β-Sitosterol Bexlosteride Dutasteride 表睪酮 Epristeride Finasteride Izonsteride L-39 Lapisteride Polyunsaturated fatty acids (α-linolenic acid, linoleic acid, γ-linolenic acid, oleic acid) Turosteride Vitamin B6 鋅

芳香酶	1,4,6-Androstatriene-3,17-dione 4-Androstene-3,6,17-trione 4-Cyclohexylaniline 4-Hydroxytestosterone 5α-DHNET Abyssinone II Aminoglutethimide Anastrozole 抗壞血酸（維生素C） Atamestane Bifonazole CGP-45,688 CGS-47,645 Clotrimazole 雙氫睪酮 Difeconazole Econazole Exemestane Fadrozole Fenarimol Finrozole Formestane Imazalil Isoconazole Ketoconazole Letrozole Liarozole MEN-11066 Miconazole Minamestane Nimorazole NKS01 ORG-33,201 Penconazole Plomestane Prochloraz Propioconazole Pyridoglutethimide Rogletimide Rotenone Talarozole Testolactone Tioconazole Triadimefon Triadimenol Troglitazone Vorozole YM511 鋅 Note: 21-Hydroxylase inhibitors may also affect androgen levels as they prevent metabolism of androgen steroid precursors.

其他

內源	雄激素: 雙氫睪酮睪酮抗雄激素: 表睪酮前體: 膽固醇 22R-羥膽固醇 20α,22R-羥膽固醇孕烯醇酮 17-羥基孕烯醇酮黃體酮 17-羥孕酮 Cortodoxone/Deoxycortisol 脫氫表雄酮硫酸脫氫表雄酮雄烯二醇雄烯二酮

間接	Estrogens/Antiestrogens (see here) GnRH agonists/antagonists (see here) Gonadotropins/Antigonadotropins (see here) Plasma proteins (SHBG, ABP, Albumin) Progestogens/Antiprogestins (see here) Prolactin

操作	腎上腺切除術垂體切除術卵巢切除術睪丸切除術

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