白细胞介素

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白细胞介素介白素(interleukin)是一组细胞因子(分泌的信号分子)。最早发现在白细胞中表达作为细胞间信号传递的手段。实际上,白细胞介素可以由多种细胞产生。免疫系统的功能,在很大程度上依赖于白细胞介素。一些罕见的白细胞介素缺陷不足都常出现自身免疫性疾病免疫缺陷

列表[编辑]

白細胞介素(interleukins)列表:

名稱 來源 [1] 目標受體[1][2] 目標細胞[1] 功能[1]
IL-1 巨噬細胞B細胞單核球[3]樹狀細胞[3] CD121a/IL1R1英语Interleukin 1 receptor, type ICD121b/IL1R2英语Interleukin 1 receptor, type II 輔助T細胞 共同刺激 [3]
B細胞 成熟和增生 [3]
自然殺手細胞英语Natural killer cell 活化[3]
巨噬細胞內皮細胞英语endothilium,和其他細胞 發炎英语inflammation[3]少量急性期反應英语acute phase protein,大量將導致發燒
IL-2 輔助型T細胞(TH1-cells) CD25/IL2RACD122/IL2RBCD132/IL2RG 活化的[3]T細胞B細胞自然殺手細胞英语Natural killer cell巨噬細胞oligodendrocyte英语s 刺激T細胞生長和分化。可以用在免疫療法英语immunotherapy治療癌症,或移植器官必須降低免疫反應的病人。

也可用於臨床試驗(ESPIRIT. Stalwart)以提高HIV陽性患者的CD4數量。

IL-3英语Interleukin 3 活化的輔助型T細胞英语T helper cell[3] 肥大細胞自然殺手細胞內皮細胞英语endothelium嗜酸性球 CD123/IL3RACD131/IL3RB 造血幹細胞英语hematopoietic stem cell 引發myeloid progenitor cells分化和增生[3]紅血球顆粒球英语granulocytes
肥大細胞 增生、釋放組織胺[3]
IL-4 Th2 cells, just activated naive CD4+ cell, memory CD4+ cells, 肥大細胞, 巨噬細胞 CD124/IL4R, CD132/IL2RG 活化B細胞 proliferation and differentiation, IgG1 and IgE synthesis.[3] Important role in allergic response (IgE)
T細胞 增生[3]
內皮細胞
IL-5英语Interleukin 5 Th2 cells, 肥大細胞, 嗜酸性球 CD125/IL5RA, CD131/IL3RB 嗜酸性球 production
B細胞 differentiation, IgA production
IL-6英语Interleukin 6 巨噬細胞Th2 cells、B細胞astrocytes內皮細胞 CD126/IL6RACD130/IR6RB 活化的B細胞 differentiation into plasma cells
漿細胞 抗體分泌
造血幹細胞 分化
T細胞和其他細胞 induces acute phase reaction, hematopoiesis, differentiation, 發炎
IL-7英语Interleukin 7 Bone marrow stromal cells and thymus stromal cells CD127/IL7RACD132/IL2RG pre/pro-B cell, pre/pro-T cell, NK cells differentiation and proliferation of lymphoid progenitor cells, involved in B, T, and NK cell survival, development, and homeostasis, ↑proinflammatory cytokines
IL-8 (CXCL8) macrophages, lymphocytes, epithelial cells, endothelial cells CXCR1/IL8RA, CXCR2/IL8RB/CD128 嗜中性球嗜鹼性球、淋巴球 嗜中性球趋化因子
IL-9英语Interleukin 9 Th2 cells, specifically by CD4+ helper cells CD129/IL9R T細胞B細胞 Potentiates IgM, IgG, IgE, stimulates 肥大細胞
IL-10英语Interleukin 10 單核球Th2 cell细胞毒性T细胞肥大細胞巨噬細胞B細胞 subset CD210/IL10RACDW210B/IL10RB 巨噬細胞 cytokine production[3]
B細胞 活化 [3]
肥大細胞
Th1 cells inhibits Th1 cytokine production (IFN-γ, TNF-β, IL-2)
Th2 cells 刺激
IL-11英语Interleukin 11 bone marrow stroma IL11RA bone marrow stroma acute phase protein production, osteoclast formation
IL-12英语Interleukin 12 樹狀細胞B細胞T細胞巨噬細胞 CD212/IL12RB1, IR12RB2 活化的[3]T細胞 differentiation into Cytotoxic T cells with IL-2,[3]IFN-γ, TNF-α, ↓ IL-10
自然殺手細胞 IFN-γ, TNF-α
IL-13英语Interleukin 13 活化的Th2 cell肥大細胞自然殺手細胞 IL13R TH2-cells, B cells, macrophages Stimulates growth and differentiation of B細胞 (IgE), inhibits TH1-cells and the production of macrophage inflammatory cytokines (e.g. IL-1, IL-6), ↓ IL-8, IL-10, IL-12
IL-14英语Interleukin 14 T cells and certain malignant B cells activated B cells controls the growth and proliferation of B細胞, inhibits Ig secretion
IL-15英语Interleukin 15 mononuclear phagocytes (and some other cells), especially macrophages following infection by virus(es) IL15RA T cells, activated B cells Induces production of Natural killer cells
IL-16英语Interleukin 16 lymphocytes, epithelial cells, eosinophils, CD8+ T cells CD4 CD4+ T cells (Th-cells) CD4+ chemoattractant
IL-17英语Interleukin 17 T helper 17 cells (Th17) CDw217/IL17RA, IL17RB epithelium, endothelium, other osteoclastogenesis, 血管新生, ↑ inflammatory 細胞激素
IL-18英语Interleukin 18 macrophages CDw218a/IL18R1 Th1 cells, NK cells Induces production of IFNγ, ↑ NK cell activity
IL-19英语Interleukin 19 - IL20R -
IL-20英语Interleukin 20 Activated keratinocytes and monocytes IL20R regulates proliferation and differentiation of keratinocytes
IL-21英语Interleukin 21 activated T helper cells, NKT cells IL21R All lymphocytes, dendritic cells costimulates activation and proliferation of CD8+ T cells, augment NK cytotoxicity, augments CD40-driven B cell proliferation, differentiation and isotype switching, promotes differentiation of Th17 cells
IL-22英语Interleukin 22 T helper 17 cells (Th17) IL22R Production of defensins from epithelial cells.[4] Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A, Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines
IL-23英语Interleukin 23 巨噬細胞, 樹狀細胞 IL23R Maintenance of IL-17 producing cells,[4] increases 血管新生 but reduces CD8 T-cell infiltration
IL-24英语Interleukin 24 melanocytes, keratinocytes, 單核球, T cells IL20R Plays important roles in tumor suppression, wound healing and psoriasis by influencing cell survival, inflammatory cytokine expression.
IL-25英语Interleukin 25 T細胞肥大細胞嗜酸性球巨噬細胞、mucosal epithelial cells LY6E Induces the production IL-4, IL-5 and IL-13, which stimulate 嗜酸性球 expansion
IL-26英语Interleukin 26 T細胞單核球 IL20R1 Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells
IL-27英语Interleukin 27 巨噬細胞樹狀細胞 IL27RA Regulates the activity of B lymphocyte and T lymphocytes
IL-28英语Interleukin 28 - IL28R Plays a role in immune defense against viruses
IL-29英语Interleukin 29 - Plays a role in host defenses against microbes
IL-30英语Interleukin 30 - IL-27英语的單鍊
IL-31英语Interleukin 31 Th2 cell英语s IL31RA 引起皮膚發炎
IL-32英语Interleukin 32 - Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2
IL-33英语Interleukin 33 - Induces helper T cells to produce type 2 cytokine
IL-35英语Interleukin 35 regulatory T cell英语s 抑制T細胞活化
IL-36英语Interleukin 36 - 調控樹狀細胞T細胞的反應

參考文獻[编辑]

  1. ^ 1.0 1.1 1.2 1.3 Unless else specified in boxes, then ref is: Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. ISBN 0-7817-9543-5. ISBN 978-0-7817-9543-2. Page 68
  2. ^ Noosheen Alaverdi & David Sehy. Cytokines - Master Regulators of the Immune System. eBioscience. 2007-05-01 [2008-02-28]. 
  3. ^ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 Cytokine tutorial, The University of Arizona
  4. ^ 引用错误:无效<ref>标签;未为name属性为Abbas_2012的引用提供文字

外部链接[编辑]