Sp8轉錄因子

Sp8轉錄因子
識別號
别名	SP8；, BTD, Sp8 transcription factor
外部ID	OMIM：608306 MGI：2443471 HomoloGene：18548 GeneCards：SP8
基因位置（人类） 染色体 7號染色體 基因座 7p21.1 起始 20,782,279 bp 终止 20,786,886 bp
基因位置（小鼠） 染色体 小鼠12号染色体 基因座 12|12 F2 起始 118,810,064 bp 终止 118,816,311 bp
基因本體 分子功能 • DNA结合 • 金屬離子結合 • nucleic acid binding • DNA-binding transcription factor activity, RNA polymerase II-specific 細胞組分 • 细胞核 生物學過程 • proximal/distal pattern formation • regulation of transcription, DNA-templated • dorsal/ventral pattern formation • embryonic limb morphogenesis • transcription, DNA-templated • regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	221833	320145
Ensembl	ENSG00000164651	ENSMUSG00000048562
UniProt	Q8IXZ3	Q8BMJ8
mRNA​序列	NM_182700 ​NM_198956	NM_177082 ​NM_001379379 ​NM_001379380
蛋白序列	NP_874359 ​NP_945194	NP_796056 ​NP_001366308 ​NP_001366309
基因位置​（UCSC）	Chr 7: 20.78 – 20.79 Mb	Chr 12: 118.81 – 118.82 Mb
PubMed​查找
維基數據
檢視/編輯人類 檢視/編輯小鼠

Sp8轉錄因子又稱為特異性蛋白8（specificity protein 8、SP-8）或Btd轉錄因子是由SP8基因編碼的人類蛋白質，位於人類的7號染色體中。Sp8是Sp/KLF家族的轉錄因子。

功能

Sp8在肢體生長早起扮演了協調的作用。在小鼠實驗中，若小鼠缺失Sp8基因會導致嚴重的腦外畸形。

延伸閱讀

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