Γ-谷氨酰水解酶

Γ-谷氨酰水解酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1L9X
識別號
别名	GGH；, GH, gamma-glutamyl hydrolase, GATD10
外部ID	OMIM：601509 MGI：1329035 HomoloGene：2881 GeneCards：GGH
基因位置（人类）
染色体	8號染色體
终止	63,039,407 bp
基因位置（小鼠）
染色体	小鼠4号染色体
终止	20,066,750 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• exopeptidase activity; • omega peptidase activity; • 水解酶活性; • gamma-glutamyl-peptidase activity;
細胞組分	• 黑色素体; • 细胞质基质; • 溶酶体; • 外排體; • 细胞核; • 細胞外區域; • 細胞外空間; • azurophil granule lumen; • specific granule lumen; • tertiary granule lumen; • 液胞;
生物學過程	• response to insulin; • response to zinc ion; • response to ethanol; • 蛋白酶解; • neutrophil degranulation; • tetrahydrofolylpolyglutamate metabolic process;
	Sources:Amigo / QuickGO
直系同源
	8836
	14590
	ENSG00000137563
	ENSMUSG00000073987
	Q92820
	Q9Z0L8
	NM_003878
	NM_010281
	NP_003869
	NP_034411
	維基數據
檢視/編輯人類	檢視/編輯小鼠

γ-谷氨酰水解酶
命名
系统命名
缩写
识别码
EC編號	3.4.19.9
CAS号	9074-87-7
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

γ-谷氨酰水解酶（英文：Gamma-glutamyl hydrolase）是一种催化以下化学反应的酶^[5]^[6]^[7]^[8]：

γ-谷氨酰键的水解

这种溶酶体或分泌的硫醇依赖性肽酶，在酸性 pH值下最活跃。

在人类中，γ-谷氨酰水解酶由GGH基因编码。^[7]^[9]^[10]该基因通过去除γ联聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。^[10]

互动通路图

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.
^ Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.
^ ^7.0 ^7.1 Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349 . PMID 8816764. doi:10.1073/pnas.93.19.10134 .
^ Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.
^ ^10.0 ^10.1 Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始内容存档于2022-12-12）.

拓展阅读

Galivan J, Ryan T, Rhee M, et al. Glutamyl hydrolase: properties and pharmacologic impact. Semin. Oncol. 1999, 26 (2 Suppl 6): 33–7. PMID 10598552.
O'Connor BM, Rotundo RF, Nimec Z, et al. Secretion of gamma-glutamyl hydrolase in vitro. Cancer Res. 1991, 51 (15): 3874–81. PMID 1713122.
Chandler CJ, Wang TT, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J. Biol. Chem. 1986, 261 (2): 928–33. PMID 2867095. doi:10.1016/S0021-9258(17)36185-9 .
Wang TT, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J. Biol. Chem. 1986, 261 (29): 13551–5. PMID 3759978. doi:10.1016/S0021-9258(18)67054-1 .
Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .
Rhee MS, Lindau-Shepard B, Chave KJ, et al. Characterization of human cellular gamma-glutamyl hydrolase. Mol. Pharmacol. 1998, 53 (6): 1040–6. PMID 9614206.
Li H, Ryan TJ, Chave KJ, Van Roey P. Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate. J. Biol. Chem. 2002, 277 (27): 24522–9. PMID 11953431. doi:10.1074/jbc.M202020200 .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Basrur V, Yang F, Kushimoto T, et al. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J. Proteome Res. 2003, 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r.
Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
He P, Varticovski L, Bowman ED, et al. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum. Pathol. 2004, 35 (10): 1196–209 [2022-12-12]. PMID 15492986. doi:10.1016/j.humpath.2004.06.014. （原始内容存档于2022-10-15）.
Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209.
Eisele LE, Chave KJ, Lehning AC, Ryan TJ. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim. Biophys. Acta. 2006, 1764 (9): 1479–86. PMID 16945597. doi:10.1016/j.bbapap.2006.06.008.
Chi A, Valencia JC, Hu ZZ, et al. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. 2007, 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.
Hayashi H, Fujimaki C, Inoue K, et al. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull. 2007, 30 (4): 839–41. PMID 17409534. doi:10.1248/bpb.30.839 .

外部链接

醫學主題詞表（MeSH）：Gamma-glutamyl+hydrolase
PDB中UniProt可用的所有結構信息之概述：Q92820 (Gamma-glutamyl hydrolase) 在PDBe-KB（英语：PDBe-KB）。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8343522-5] Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n.

[pmid7565632-6] Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632.

[pmid8816764-7] 7.0 ^7.1 Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349 . PMID 8816764. doi:10.1073/pnas.93.19.10134 .

[pmid8621474-8] Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525 .

[pmid10570974-9] Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5.

[entrez-10] 10.0 ^10.1 Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始内容存档于2022-12-12）.

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查论编酶
活性	活性位点结合位点催化三联体负氧离子洞酶催化混杂（英语：Enzyme promiscuity）催化最适酶（英语：Catalytically perfect enzyme）辅因子辅酶酶促反应
调节	别构调节协同性（英语：Cooperativity）酶抑制剂酶激活剂
分类	EC編號蛋白质超家族蛋白质家族酶列表
动力学	酶动力学伊迪-霍夫斯蒂图（英语：Eadie–Hofstee diagram）哈尼斯-伍尔夫图（英语：Hanes–Woolf plot）双倒数图米氏动力学
类型	EC1 氧化還原酶（列表（英语：List of EC numbers (EC 1)）） EC2 轉移酶（列表（英语：List of EC numbers (EC 2)）） EC3 水解酶（列表（英语：List of EC numbers (EC 3)）） EC4 裂合酶（列表（英语：List of EC numbers (EC 4)）） EC5 異構酶（列表（英语：List of EC numbers (EC 5)）） EC6 連接酶（列表（英语：List of EC numbers (EC 6)）） EC7 移位酶（英语：Translocase）（列表（英语：List of EC numbers (EC 7)））