18-羥基-11-脫氧皮質酮

18-羥基-11-脫氧皮質酮
	IUPAC名; (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
別名	18,21-dihydroxy-4-pregnene-3,20-dione
識別
CAS號	379-68-0
PubChem	64970
ChemSpider	58495
SMILES	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO;
MeSH	18-hydroxydeoxycorticosterone
性質
化學式	C21H30O4
摩爾質量	346.5 g·mol⁻¹
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

18-羥基-11-脫氧皮質酮（英語：18-Hydroxy-11-deoxycorticosterone，縮寫18-OH-DOC）是CYP450 酶 CYP11B3催化11-脫氧皮質酮發生羥基化的產物，CYP11B3主要在大鼠新生兒的腎上腺表達^[1]^[2]。

參考文獻[編輯]

^ Fujii S, Momoi K, Okamoto M, Yamano T, Okada T, Terasawa T. 18,19-Dihydroxydeoxycorticosterone, a new metabolite produced from 18-hydroxydeoxycorticosterone by cytochrome P-450(11) beta. Chemical synthesis and structural analysis by 1H NMR. Biochemistry. June 1984, 23 (12): 2558–64. PMID 6466598. doi:10.1021/bi00307a004.
^ Zhou MY, Gomez-Sanchez EP, Foecking MF, Gomez-Sanchez CE. Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC. Molecular and Cellular Endocrinology. October 1995, 114 (1–2): 137–45. PMID 8674838. doi:10.1016/0303-7207(95)03653-o.