抑癌蛋白M

OSM
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1EVS
識別號
別名	OSM；, Osm, OncoM, oncostatin M
外部ID	OMIM：165095 MGI：104749 HomoloGene：10741 GeneCards：OSM
基因位置（人類）
染色體	22號染色體
終止	30,266,851 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	4,191,026 bp
基因本體
分子功能	• 細胞因子活性; • oncostatin-M receptor binding; • 生長因子活性;
細胞組分	• 細胞外區域; • 細胞外空間;
生物學過程	• oncostatin-M-mediated signaling pathway; • positive regulation of peptidyl-serine phosphorylation; • multicellular organism development; • 免疫反應; • positive regulation of cell population proliferation; • positive regulation of acute inflammatory response; • regulation of growth; • 細胞增殖; • negative regulation of hormone secretion; • positive regulation of cell division; • positive regulation of MAPK cascade; • negative regulation of cell population proliferation; • positive regulation of transcription by RNA polymerase II; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • positive regulation of peptidyl-tyrosine phosphorylation; • cytokine-mediated signaling pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of inflammatory response; • positive regulation of protein kinase B signaling; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	5008
	18413
	ENSG00000099985
	ENSMUSG00000058755
	P13725
	P53347
	NM_020530; NM_001319108
	NM_001013365
	NP_001306037; NP_065391
	NP_001013383
	維基數據
檢視/編輯人類	檢視/編輯小鼠

抑癌蛋白M（英語：Oncostatin M，縮寫OSM，也譯作制癌蛋白M、抑瘤素M）是由人類基因 OSM 編碼的蛋白質^[5]，由209個氨基酸殘基組成。OSM是一種多效的細胞因子，屬於IL-6家族^[6]，和白血病抑制因子（LIF）在結構和功能上類似^[6]，在肝臟發育、造血作用、炎症反應以及中樞神經系統發育和骨形成中有重要作用^[7]。

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565 . PMID 1717982. doi:10.1073/pnas.88.19.8641.
^ ^6.0 ^6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.
^ Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087 . PMID 20051625. doi:10.1172/JCI40568. （原始內容存檔於2020-05-29）. 簡明摘要 – ScienceDaily.

延伸閱讀

Schieven GL, Kallestad JC, Brown TJ, Ledbetter JA, Linsley PS. Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase. J. Immunol. September 1992, 149 (5): 1676–82. PMID 1324279.
Hermanns HM, Radtke S, Schaper F, Heinrich PC, Behrmann I. Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. December 2000, 275 (52): 40742–8. PMID 11016927. doi:10.1074/jbc.M005408200.

外部連結

醫學主題詞表（MeSH）：Oncostatin+M

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000099985 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000058755 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1717982-5] Rose TM, Bruce AG. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Natl. Acad. Sci. U.S.A. October 1991, 88 (19): 8641–5. PMC 52565 . PMID 1717982. doi:10.1073/pnas.88.19.8641.

[pmid12811586-6] 6.0 ^6.1 Tanaka M, Miyajima A. Oncostatin M, a multifunctional cytokine. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 2003, 149: 39–52. ISBN 978-3-540-20213-4. PMID 12811586. doi:10.1007/s10254-003-0013-1.

[Walker_2010-7] Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest. 2010, 120 (2): 582–92 [2019-12-09]. PMC 2810087 . PMID 20051625. doi:10.1172/JCI40568. （原始內容存檔於2020-05-29）. 簡明摘要 – ScienceDaily.

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