二氢叶酸还原酶 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/14/Dihydrofolate_reductase_1DRF.png/250px-Dihydrofolate_reductase_1DRF.png) |
有效结构 |
PDB |
直系同源检索:PDBe, RCSB
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PDB查询代码列表 |
1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U, 1S3V, 1S3W, 1U71, 1U72, 1YHO, 2C2S, 2C2T, 2DHF, 2W3A, 2W3B, 2W3M, 3EIG, 3F8Y, 3F8Z, 3F91, 3FS6, 3GHC, 3GHV, 3GHW, 3GI2, 3GYF
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代号 |
DHFR; DHFRP1; DYR |
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扩展标识 |
遗传学:126060 鼠基因:94890 同源基因:56470 GeneCards: DHFR Gene |
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EC编号 |
1.5.1.3 |
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物种 |
人类 |
小鼠 |
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Entrez |
1719 |
13361 |
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Ensembl |
ENSG00000228716 |
ENSMUSG00000021707 |
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UniProt |
P00374 |
Q544T5 |
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mRNA序列 |
NM_000791.3 |
NM_010049.3 |
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蛋白序列 |
NP_000782.1 |
NP_034179.1 |
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基因位置 |
Chr 5: 79.92 – 79.95 Mb |
Chr 13: 93.12 – 93.16 Mb |
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PubMed查询 |
[2] |
[3] |
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二氢叶酸还原酶[1](英语:Dihydrofolate reductase,简称为DHFR)是一种将二氢叶酸还原为四氢叶酸的酶,并以NADPH作为电子供体,后者可被转换为多种四氢叶酸辅酶被用于化学上的一碳单位转移。在人体中,二氢叶酸还原酶是由DHFR基因编码的[2][3]。它位于5号染色体的q11→q22区域[4]。
- ^ [1][永久失效链接]
- ^ Chen MJ, Shimada T, Moulton AD, Harrison M, Nienhuis AW. Intronless human dihydrofolate reductase genes are derived from processed RNA molecules. Proc. Natl. Acad. Sci. U.S.A. December 1982, 79 (23): 7435–9. PMC 347354
. PMID 6961421. doi:10.1073/pnas.79.23.7435.
- ^ Chen MJ, Shimada T, Moulton AD, Cline A, Humphries RK, Maizel J, Nienhuis AW. The functional human dihydrofolate reductase gene. J. Biol. Chem. March 1984, 259 (6): 3933–43 [2011-09-20]. PMID 6323448. (原始内容存档于2020-01-25).
- ^ Funanage VL, Myoda TT, Moses PA, Cowell HR. Assignment of the human dihydrofolate reductase gene to the q11----q22 region of chromosome 5. Mol. Cell. Biol. October 1984, 4 (10): 2010–6. PMC 369017
. PMID 6504041.