炔诺酮
外观
![]() | 此条目可参照英语维基百科相应条目来扩充。 (2023年2月17日) |
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临床资料 | |
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商品名 | Alone: Aygestin, Camila, Heather, Micronor, Primolut N, others; With EE: Lo Loestrin, Loestrin, Microgestin, Modicon, Norinyl, Ortho-Novum, others; With E2: Activella, Activelle, Estalis, Kliogest, Necon, Novofem, Trisequens, others |
其他名称 | NET; Norethindrone; NSC-9564; LG-202; Ethinylnortestosterone; Norpregneninolone; Anhydrohydroxy-norprogesterone; Ethinylestrenolone; 17α-Ethynyl-19-nortestosterone; 17α-Ethynylestra-4-en-17β-ol-3-one; 17α-Hydroxy-19-norpregn-4-en-20-yn-3-one |
AHFS/Drugs.com | 国际药品名称 |
MedlinePlus | a604034 |
给药途径 | By mouth, intramuscular injection (as NETE) |
药物类别 | Progestin; Progestogen |
ATC码 | |
药物动力学数据 | |
生物利用度 | 47–73% (mean 64%)[1][2] |
血浆蛋白结合率 | 97%: Albumin: 61%; SHBG: 36% |
药物代谢 | Mainly CYP3A4 (liver);[3] also 5α-/5β-reductase, 3α-/3β-HSD, and aromatase |
生物半衰期 | 5.2–12.8 hours (mean 8.0 hours)[1] |
识别信息 | |
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CAS号 | 68-22-4 ![]() |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.619 |
化学信息 | |
化学式 | C20H26O2 |
摩尔质量 | 298.419 g/mol |
3D模型(JSmol) | |
熔点 | 203至204 °C(397至399 °F) |
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炔诺酮(英语:Norethisterone 或 英语:norethindrone)是一种黄体制剂药物,用做口服避孕药和激素替代疗法药物以及治疗一些妇科疾病[4]。
参考文献
[编辑]- ^ 1.0 1.1 Stanczyk, Frank Z. Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818.
- ^ Fotherby K. Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy. Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9.
- ^ Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025.
- ^ Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. Maternity and Women's Health Care - E-Book. Elsevier Health Sciences. 27 December 2013: 135– [2019-06-30]. ISBN 978-0-323-29368-6. (原始内容存档于2020-01-04).