p53 p63 p73家族

p53 p63 p73 家族 是一個抑癌基因家族^[1]^[2]

包括：

p53
TP63（也被稱為"p63"）
p73

有時候也簡稱為「p53家族」^[3]。

p53家族的進化關係

p53、p63與p73不但在結構與功能上相似，在進化上也有相關性。整個p53家族都是從無脊椎動物的p63/p73祖先基因中進化而來^[4]。p53最早在軟骨魚基因組的p63/p73基因重複中分化出來^[4]，p63/p73此後在硬骨魚中再分化為p63和p73^[4]。後來它們各自發展出了不同的結構與功能，最終形成了可以區分的三個基因—TP63、p73、p53。

參考文獻

^ Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell. Sci. May 2000, 113 (10): 1661–70. PMID 10769197.
^ Caleb Ellicott Finch. The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. 2007: 350– [23 December 2010]. ISBN 978-0-12-373657-4.
^ Chen S, Moroi Y, Urabe K; et al. Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Clin. Exp. Dermatol. July 2008, 33 (5): 634–40. PMID 18627398. doi:10.1111/j.1365-2230.2008.02851.x.
^ ^4.0 ^4.1 ^4.2 Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter.. The origins and evolution of the p53 family of genes. Cold Spring Harbor Perspectives in Biology. 2010, 2.

[pmid10769197-1] Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell. Sci. May 2000, 113 (10): 1661–70. PMID 10769197.

[Finch2007-2] Caleb Ellicott Finch. The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. 2007: 350– [23 December 2010]. ISBN 978-0-12-373657-4.

[pmid18627398-3] Chen S, Moroi Y, Urabe K; et al. Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Clin. Exp. Dermatol. July 2008, 33 (5): 634–40. PMID 18627398. doi:10.1111/j.1365-2230.2008.02851.x.

[Levine_et_al._2010-4] 4.0 ^4.1 ^4.2 Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter.. The origins and evolution of the p53 family of genes. Cold Spring Harbor Perspectives in Biology. 2010, 2.

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