胰岛素样生长因子1受体：修订间差异

Insulin-like growth factor 1 receptor; 胰岛素样生长因子1受体
	The first three domains of insulin-like growth factor 1 receptor. PDB rendering based on 1igr.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU
标识
代号	IGF1R; CD221; IGFIR; IGFR; JTK13
扩展标识	遗传学：147370 鼠基因：96433 同源基因：30997 IUPHAR: ChEMBL: 1957 GeneCards: IGF1R Gene
EC編號	2.7.10.1
基因本体论描述
分子功能	· G-protein alpha-subunit binding; · protein tyrosine kinase activity; · insulin-like growth factor-activated receptor activity; · insulin receptor binding; · protein binding; · insulin-like growth factor binding; · ATP binding; · insulin-like growth factor I binding; · identical protein binding; · phosphatidylinositol 3-kinase binding; · insulin binding; · insulin receptor substrate binding;
细胞成分	· plasma membrane; · integral component of plasma membrane; · caveola; · membrane; · neuron projection; · intracellular membrane-bounded organelle; · receptor complex;
生物过程	· immune response; · signal transduction; · axonogenesis; · brain development; · positive regulation of cell proliferation; · insulin receptor signaling pathway; · negative regulation of muscle cell apoptotic process; · phosphatidylinositol 3-kinase signaling; · establishment of cell polarity; · male sex determination; · positive regulation of cell migration; · mammary gland development; · exocrine pancreas development; · positive regulation of cytokinesis; · response to vitamin E; · peptidyl-tyrosine autophosphorylation; · negative regulation of apoptotic process; · positive regulation of MAPK cascade; · positive regulation of DNA replication; · regulation of JNK cascade; · protein autophosphorylation; · insulin-like growth factor receptor signaling pathway; · phosphatidylinositol-mediated signaling; · protein tetramerization; · protein heterooligomerization; · inactivation of MAPKK activity; · positive regulation of protein kinase B signaling; · negative regulation of protein kinase B signaling; · prostate gland epithelium morphogenesis; · positive regulation of steroid hormone biosynthetic process;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
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2015年4月12日 (日) 10:39的版本

胰岛素样生长因子1受体（英語：insulin-like growth factor 1，IGF-1R）是人类细胞表面发现的蛋白质，是激素胰岛素样生长因子1（IGF-1）的细胞表面受体，属于酪氨酸激酶受体家族。其配体IGF-1，是一种在分子结构上与多肽类激素胰岛素类似的激素，在生长发育和成人的合成代谢中有重要作用，可引起骨骼肌或其他组织的过度增殖。完全缺失IGF-1受体的小鼠会在生长发育到一定阶段时死亡，并伴随有体重急剧下降，带有单个IGF-1R等位基因缺失的小鼠仍能正常发育，但存在约15%的体重减少，这表明了此受体强烈的生长促进作用。

相互作用

胰岛素样生长因子1受体可与下列蛋白质相互作用：

调控

There is evidence to suggest that IGF1R is negatively regulated by the microRNA miR-7.^[17]

参考文献

^ Taya, S; Inagaki, N; Sengiku, H; Makino, H; Iwamatsu, A; Urakawa, I; et al. Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J. Cell Biol. November 2001, 155 (5): 809–20. PMC 2150867 . PMID 11724822. doi:10.1083/jcb.200106139. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Arbet-Engels, C; Tartare-Deckert, S; Eckhart, W. C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor. J. Biol. Chem. February 1999, 274 (9): 5422–8. PMID 10026153. doi:10.1074/jbc.274.9.5422. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ ^3.0 ^3.1 ^3.2 Sehat, B; Andersson, S; Girnita, L; Larsson, O. Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res. July 2008, 68 (14): 5669–77. PMID 18632619. doi:10.1158/0008-5472.CAN-07-6364. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Rotem-Yehudar, R; Galperin, E; Horowitz, M. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. J. Biol. Chem. August 2001, 276 (35): 33054–60. PMID 11423532. doi:10.1074/jbc.M009913200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ ^5.0 ^5.1 Vecchione, A; Marchese, A; Henry, P; Rotin, D; Morrione, A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol. Cell. Biol. May 2003, 23 (9): 3363–72. PMC 153198 . PMID 12697834. doi:10.1128/mcb.23.9.3363-3372.2003. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^6.0 ^6.1 ^6.2 Dey, BR; Frick, K; Lopaczynski, W; Nissley, SP; Furlanetto, RW. Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10. Mol. Endocrinol. June 1996, 10 (6): 631–41. PMID 8776723. doi:10.1210/mend.10.6.8776723. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ He, W; Rose, DW; Olefsky, JM; Gustafson, TA. Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. J. Biol. Chem. March 1998, 273 (12): 6860–7. PMID 9506989. doi:10.1074/jbc.273.12.6860. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Morrione, A; Valentinis, B; Li, S; Ooi, JY; Margolis, B; Baserga, R. Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res. July 1996, 56 (14): 3165–7. PMID 8764099. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^9.0 ^9.1 Mañes, S; Mira, E; Gómez-Mouton, C; Zhao, ZJ; Lacalle, RA; Martínez-A, C. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. April 1999, 19 (4): 3125–35. PMC 84106 . PMID 10082579. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^10.0 ^10.1 Tartare-Deckert, S; Sawka-Verhelle, D; Murdaca, J; Van Obberghen, E. Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J. Biol. Chem. October 1995, 270 (40): 23456–60. PMID 7559507. doi:10.1074/jbc.270.40.23456. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Mothe, I; Delahaye, L; Filloux, C; Pons, S; White, MF; Van Obberghen, E. Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Mol. Endocrinol. December 1997, 11 (13): 1911–23. PMID 9415396. doi:10.1210/mend.11.13.0029. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^12.0 ^12.1 Seely, BL; Reichart, DR; Staubs, PA; Jhun, BH; Hsu, D; Maegawa, H; et al. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J. Biol. Chem. August 1995, 270 (32): 19151–7. PMID 7642582. doi:10.1074/jbc.270.32.19151. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Santen, RJ; Song, RX; Zhang, Z; Kumar, R; Jeng, MH; Masamura, A; et al. Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity. Endocr. Relat. Cancer. 12. July 2005,. 12 Suppl 1: S61–73. PMID 16113100. doi:10.1677/erc.1.01018. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Dey, BR; Spence, SL; Nissley, P; Furlanetto, RW. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. September 1998, 273 (37): 24095–101. PMID 9727029. doi:10.1074/jbc.273.37.24095. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Dey, BR; Furlanetto, RW; Nissley, P. Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. Biochem. Biophys. Res. Commun. November 2000, 278 (1): 38–43. PMID 11071852. doi:10.1006/bbrc.2000.3762. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Craparo, A; Freund, R; Gustafson, TA. 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J. Biol. Chem. April 1997, 272 (17): 11663–9. PMID 9111084. doi:10.1074/jbc.272.17.11663. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Jiang, L; Liu, X; Chen, Z; Jin, Y; Heidbreder, CE; Kolokythas, A; et al. MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochemical Journal. 2010, 432 (1): 199–205. PMC 3130335 . PMID 20819078. doi:10.1042/BJ20100859. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

延伸阅读

Benito, M; Valverde, AM; Lorenzo, M. IGF-I: a mitogen also involved in differentiation processes in mammalian cells.. Int. J. Biochem. Cell Biol. 1996, 28 (5): 499–510. PMID 8697095. doi:10.1016/1357-2725(95)00168-9. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Butler, AA; Yakar, S; Gewolb, IH; Karas, M; Okubo, Y; LeRoith, D. Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1999, 121 (1): 19–26. PMID 9972281. doi:10.1016/S0305-0491(98)10106-2. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Zhang, X; Yee, D. Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.. Breast Cancer Res. 2001, 2 (3): 170–5. PMC 138771 . PMID 11250706. doi:10.1186/bcr50. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Gross, JM; Yee, D. The type-1 insulin-like growth factor receptor tyrosine kinase and breast cancer: biology and therapeutic relevance.. Cancer Metastasis Rev. 2004, 22 (4): 327–36. PMID 12884909. doi:10.1023/A:1023720928680. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Adams, TE; McKern, NM; Ward, CW. Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor.. Growth Factors. 2005, 22 (2): 89–95. PMID 15253384. doi:10.1080/08977190410001700998. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Surmacz, E; Bartucci, M. Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.. J. Exp. Clin. Cancer Res. 2005, 23 (3): 385–94. PMID 15595626. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Wood, AW; Duan, C; Bern, HA. Insulin-like growth factor signaling in fish. Int. Rev. Cytol. International Review of Cytology. 2005, 243: 215–85. ISBN 9780123646477. PMID 15797461. doi:10.1016/S0074-7696(05)43004-1. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Sarfstein, R; Maor, S; Reizner, N; Abramovitch, S; Werner, H. Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol. Cell. Endocrinol. 2006, 252 (1–2): 241–6. PMID 16647191. doi:10.1016/j.mce.2006.03.018. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

外部链接

醫學主題詞表（MeSH）：IGF-1+Receptor

[pmid11724822-1] Taya, S; Inagaki, N; Sengiku, H; Makino, H; Iwamatsu, A; Urakawa, I; et al. Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J. Cell Biol. November 2001, 155 (5): 809–20. PMC 2150867 . PMID 11724822. doi:10.1083/jcb.200106139. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10026153-2] Arbet-Engels, C; Tartare-Deckert, S; Eckhart, W. C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor. J. Biol. Chem. February 1999, 274 (9): 5422–8. PMID 10026153. doi:10.1074/jbc.274.9.5422. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid18632619-3] 3.0 ^3.1 ^3.2 Sehat, B; Andersson, S; Girnita, L; Larsson, O. Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res. July 2008, 68 (14): 5669–77. PMID 18632619. doi:10.1158/0008-5472.CAN-07-6364. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11423532-4] Rotem-Yehudar, R; Galperin, E; Horowitz, M. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. J. Biol. Chem. August 2001, 276 (35): 33054–60. PMID 11423532. doi:10.1074/jbc.M009913200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid12697834-5] 5.0 ^5.1 Vecchione, A; Marchese, A; Henry, P; Rotin, D; Morrione, A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol. Cell. Biol. May 2003, 23 (9): 3363–72. PMC 153198 . PMID 12697834. doi:10.1128/mcb.23.9.3363-3372.2003. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid8776723-6] 6.0 ^6.1 ^6.2 Dey, BR; Frick, K; Lopaczynski, W; Nissley, SP; Furlanetto, RW. Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10. Mol. Endocrinol. June 1996, 10 (6): 631–41. PMID 8776723. doi:10.1210/mend.10.6.8776723. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid9506989-7] He, W; Rose, DW; Olefsky, JM; Gustafson, TA. Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains. J. Biol. Chem. March 1998, 273 (12): 6860–7. PMID 9506989. doi:10.1074/jbc.273.12.6860. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid8764099-8] Morrione, A; Valentinis, B; Li, S; Ooi, JY; Margolis, B; Baserga, R. Grb10: A new substrate of the insulin-like growth factor I receptor. Cancer Res. July 1996, 56 (14): 3165–7. PMID 8764099. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10082579-9] 9.0 ^9.1 Mañes, S; Mira, E; Gómez-Mouton, C; Zhao, ZJ; Lacalle, RA; Martínez-A, C. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. April 1999, 19 (4): 3125–35. PMC 84106 . PMID 10082579. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid7559507-10] 10.0 ^10.1 Tartare-Deckert, S; Sawka-Verhelle, D; Murdaca, J; Van Obberghen, E. Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system. J. Biol. Chem. October 1995, 270 (40): 23456–60. PMID 7559507. doi:10.1074/jbc.270.40.23456. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid9415396-11] Mothe, I; Delahaye, L; Filloux, C; Pons, S; White, MF; Van Obberghen, E. Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. Mol. Endocrinol. December 1997, 11 (13): 1911–23. PMID 9415396. doi:10.1210/mend.11.13.0029. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid7642582-12] 12.0 ^12.1 Seely, BL; Reichart, DR; Staubs, PA; Jhun, BH; Hsu, D; Maegawa, H; et al. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J. Biol. Chem. August 1995, 270 (32): 19151–7. PMID 7642582. doi:10.1074/jbc.270.32.19151. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid16113100-13] Santen, RJ; Song, RX; Zhang, Z; Kumar, R; Jeng, MH; Masamura, A; et al. Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity. Endocr. Relat. Cancer. 12. July 2005,. 12 Suppl 1: S61–73. PMID 16113100. doi:10.1677/erc.1.01018. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid9727029-14] Dey, BR; Spence, SL; Nissley, P; Furlanetto, RW. Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. September 1998, 273 (37): 24095–101. PMID 9727029. doi:10.1074/jbc.273.37.24095. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11071852-15] Dey, BR; Furlanetto, RW; Nissley, P. Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. Biochem. Biophys. Res. Commun. November 2000, 278 (1): 38–43. PMID 11071852. doi:10.1006/bbrc.2000.3762. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid9111084-16] Craparo, A; Freund, R; Gustafson, TA. 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J. Biol. Chem. April 1997, 272 (17): 11663–9. PMID 9111084. doi:10.1074/jbc.272.17.11663. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid20819078-17] Jiang, L; Liu, X; Chen, Z; Jin, Y; Heidbreder, CE; Kolokythas, A; et al. MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochemical Journal. 2010, 432 (1): 199–205. PMC 3130335 . PMID 20819078. doi:10.1042/BJ20100859. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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2015年4月12日 (日) 10:39的版本

相互作用

调控

相关条目

参考文献

延伸阅读

外部链接