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冠狀動脈疾病

維基百科,自由的百科全書
冠狀動脈疾病
coronary artery disease
又稱Atherosclerotic heart disease,[1]atherosclerotic vascular disease,[2]coronary heart disease[3]
冠狀動脈粥樣(atherosclerosis)硬化示意圖
症狀胸痛呼吸困難[4]
併發症心臟衰竭心律不整[5]
類型動脈疾病[*]心血管疾病疾病
病因心臟的動脈英語Coronary arteries 粥樣硬化[6]
風險因素高血壓吸菸糖尿病、缺乏運動、肥胖症高膽固醇血症[6]
診斷方法心電圖心臟壓力測試, 冠狀動脈血管電腦斷層掃描英語coronary computed tomographic angiography, 冠狀動脈血管攝影英語Coronary catheterization
預防健康的飲食、規律運動、維持健康的體重、不吸菸[7]
治療經皮冠狀動脈介入治療 (PCI), 冠狀動脈旁路移植 (CABG)[8]
藥物阿司匹林, β受體阻滯劑, 硝酸甘油英語医用硝酸甘油[8]
盛行率1.1 億 (2015)[9]
死亡數
分類和外部資源
醫學專科心臟病學心臟外科
ICD-9-CM410-414.99、​414.0、​414.9、​414.00
OMIM300464、​607339、​608316、​608318、​608320、​610947、​611139、​612030、​614293
MedlinePlus007115
eMedicine349040
[編輯此條目的維基數據]

冠狀動脈疾病coronary artery disease,CAD)簡稱冠脈病[11][12],是冠狀動脈結構和(或)功能異常,引起冠脈狹窄、痙攣、閉塞、動脈瘤英語Coronary artery aneurysm夾層的疾病[13][14][15]。冠脈病最常見由粥樣硬化引起,其他尚有因痙攣、栓塞、炎症,及先天畸形等所致。由於冠脈病使心肌的血流灌注降低,輕可導致胸痛(心絞痛),重則引起心臟病發作(心肌梗死)。

冠狀動脈心臟病coronary heart disease,CHD[16][17])簡稱冠心病,是造成心肌缺血和(或)梗死的一組臨床綜合徵,屬於最常見的心血管疾病[18]

臨床上,冠脈病與冠心病兩者範圍常重疊且混用,但前者不一定具有心肌缺血或梗死,且可為後者的早期病變。簡言之,冠脈病含蓋範圍較廣,冠心病屬於一種冠脈病[19]。冠脈病或冠心病有許多異名近義詞,如:心肌缺血(myocardial ischemia)、缺血性心臟病ischemic heart disease,IHD)[20]冠狀動脈粥樣硬化心臟病coronary atherosclerotic heart disease,CAHD)[21][22]冠狀動脈粥樣硬化心血管疾病[23]等等。

冠脈病型態包含穩定型心絞痛非穩定型心絞痛英語Unstable angina心肌梗塞猝死[24]

症狀

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常見的症狀包括胸痛或不適,有時會轉移到肩膀、手臂、背部、頸部或下顎。有些人可能會有胸口灼熱的感覺。通常症狀在運動或情緒壓力下出現,持續時間不超過數分鐘且休息會緩解。有時會伴隨呼吸困難,有時則是毫無症狀[4]。少數人以心肌梗塞為最初的表現。其他可能的併發症包含心臟衰竭心律不整[5]

成因與診斷

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危險因子包括:高血壓抽菸糖尿病、缺乏運動、肥胖血液中膽固醇含量過高、營養不良和酗[6][25]。其他的危險因子也包括憂鬱症[26]。潛在的病理機制與冠狀動脈血管粥狀硬化有關[6]心電圖心臟壓力測試冠狀動脈血管攝影英語Coronary catheterization(一種血管攝影)是常見有助於診斷的工具[27]

預防與治療

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預防方式包括:健康飲食、規律運動、體重控制以及戒菸[7]。視情況合併使用藥物控制高血糖、高膽固醇或高血壓[7]。只有很有限的證據支持對低風險且沒有症狀的民眾實施篩檢[28]

由於冠狀動脈是主動脈的分支,負責供應足夠氧和營養素予心肌,當冠狀動脈被膽固醇或血凝塊阻塞時,會形成斑塊而引致心臟供血不足。最初治療和預防措施一樣,包括生活方式調整以及三高(高血糖、高膽固醇或高血壓)的控制[8][29]。進一步的藥物治療包括阿斯匹靈乙型交感神經阻斷劑硝酸甘油的醫療用途[8]。在病況較嚴重的情形下,會考慮進行經皮冠狀動脈介入治療或是冠狀動脈繞道手術[8][30]。對於穩定型心絞痛,經皮冠狀動脈介入治療或是冠狀動脈繞道手術,對於提升存活年限或降低未來心臟病發的效果仍不明確[31]

冠狀動脈球囊粵語稱「通波仔」,冠狀動脈球囊成形術是以氣球(球囊)擴張冠狀動脈,使之暢通。若冠狀動脈血液被嚴重阻塞,可引致很嚴重的後果。血液不能供應到心臟會引致劇烈的心絞痛,然後心臟會衰竭,最嚴重的可導致死亡。當冠心病發作時,須立即口含醫師處方的「脷底丸」(粵語舌下丸之義),其可擴張血管,以增加冠狀動脈血流量。冠心病發作可引致嚴重後果,應立即叫救護車求助。

健康的生活方式

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藥物治療

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手術治療

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流行病學

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冠狀動脈疾病在西元2002年是全球第一大死因[38],也是人們住院的主要原因之一[39]。2013年也是全球死因首位,死亡人數自1990年574萬人(12%)攀升至2013年814萬人(16.8%)[18]。而隨著診斷及治療技術進步,經年齡校正後的冠狀動脈疾病死亡率自1980年至2010年則呈現下降趨勢,尤其在已開發國家更為顯著[40]。同時經年齡校正後的冠狀動脈疾病病例數在1990至2010年間亦呈現下降趨勢[41]。根據美國本土於2010年統計,冠狀動脈疾病盛行率於大於65歲族群為20%、45至64歲為7%、18至45歲為1.3%。針對同一年齡層相比,男性的發生率較女性高[42]

參考資料

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外部連結

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