CDX1
外觀
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Caudal type homeobox 1尾型同源框1 | |||
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標識 | |||
代號 | CDX1; MGC116915 | ||
擴展標識 | 遺傳學:600746 鼠基因:88360 同源基因:1366 GeneCards: CDX1 Gene | ||
RNA表達模式 | |||
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更多表達數據 | |||
直系同源體 | |||
物種 | 人類 | 小鼠 | |
Entrez | 1044 | 12590 | |
Ensembl | ENSG00000113722 | ENSMUSG00000024619 | |
UniProt | P47902 | P18111 | |
mRNA序列 | NM_001804 | NM_009880 | |
蛋白序列 | NP_001795 | NP_034010 | |
基因位置 |
Chr 5: 149.55 – 149.56 Mb |
Chr 18: 61.02 – 61.04 Mb | |
PubMed查詢 | [1] | [2] | |
同源框蛋白CDX-1(Homeobox protein CDX-1)是一種由基因CDX1編碼的蛋白質。[1][2]
該基因是尾型同源框轉錄因子基因家族的一員。其編碼的DNA結合蛋白用以調控腸道特異性基因的表達和腸上皮細胞的分化。已知它能誘導腸道鹼性磷酸酶的表達,並抑制β-連環素和T細胞因子的轉錄活性[2]。
參考文獻
[編輯]- ^ Bonner CA, Loftus SK, Wasmuth JJ. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics. Feb 1996, 28 (2): 206–11. PMID 8530027. doi:10.1006/geno.1995.1132.
- ^ 2.0 2.1 Entrez Gene: CDX1 caudal type homeobox transcription factor 1.
延伸閱讀
[編輯]- Dixon, Jill; Edwards, Sara J.; Gladwin, Amanda J.; Dixon, Michael J.; Loftus, Stacie K.; Bonner, Cynthia A.; Koprivnikar, Kathryn; Wasmuth, John J. Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group. Nat. Genet. 1996, 12 (2): 130–6. PMID 8563749. doi:10.1038/ng0296-130.
- Mallo GV, Rechreche H, Frigerio JM; et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer. 1997, 74 (1): 35–44. PMID 9036867. doi:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1.
- Mizoshita T, Inada K, Tsukamoto T; et al. Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer. 2002, 4 (4): 185–91. PMID 11846061. doi:10.1007/PL00011741.
- Suh ER, Ha CS, Rankin EB; et al. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J. Biol. Chem. 2002, 277 (39): 35795–800. PMID 12124393. doi:10.1074/jbc.M205567200.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Domon-Dell C, Schneider A, Moucadel V; et al. Cdx1 homeobox gene during human colon cancer progression. Oncogene. 2003, 22 (39): 7913–21. PMID 12970739. doi:10.1038/sj.onc.1206756.
- Wong NA, Britton MP, Choi GS; et al. Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (2): 574–9. PMC 327189
. PMID 14704280. doi:10.1073/pnas.0307190101.
- Rankin EB, Xu W, Silberg DG, Suh E. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286 (5): G872–80. PMID 14715525. doi:10.1152/ajpgi.00326.2003.
- Béland M, Pilon N, Houle M; et al. Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex. Mol. Cell. Biol. 2004, 24 (11): 5028–38. PMC 416402
. PMID 15143193. doi:10.1128/MCB.24.11.5028-5038.2004.
- Guo RJ, Huang E, Ezaki T; et al. Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J. Biol. Chem. 2004, 279 (35): 36865–75. PMID 15215241. doi:10.1074/jbc.M405213200.
- Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Alkhoury F, Malo MS, Mozumder M; et al. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289 (2): G285–90. PMID 15774940. doi:10.1152/ajpgi.00037.2005.
- Wong NA, Wilding J, Bartlett S; et al. CDX1 is an important molecular mediator of Barrett's metaplasia. Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (21): 7565–70. PMC 1140438
. PMID 15894614. doi:10.1073/pnas.0502031102.
外部連結
[編輯]CDX1引用了美國國家醫學圖書館提供的資料,這些資料屬於公共領域。
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