11β-羥孕酮

11β-羥孕酮
	IUPAC名; (8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
別名	11β-OHP; 21-Deoxycorticosterone; 21-Desoxycorticosterone; 11β-Hydroxypregn-4-ene-3,20-dione
識別
CAS號	600-57-7
PubChem	101788
ChemSpider	91968
SMILES	CC(=O)[C@H]1CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C;
InChI	1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1;
InChIKey	BFZHCUBIASXHPK-ATWVFEABSA-N
ChEBI	28247
KEGG	C05498
性質
化學式	C21H30O3
摩爾質量	330.46 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

11β-羥孕酮（英語：11β-Hydroxyprogesterone，縮寫11β-OHP，也稱為21-脫氧皮質酮，21-deoxycorticosterone，或11β-羥基孕-4-烯-3,20-二酮，11β-hydroxypregn-4-ene-3,20-dione）是一種天然內源性甾體激素和孕酮的衍生物，是強效的鹽皮質激素^[1]。11β-OHP主要由類固醇11-β-羥化酶（英語：Steroid 11-beta-hydroxylase）（CYP11B1）羥基化孕酮生成^[2]^[3]，也有少量由醛固酮合酶（英語：Aldosterone synthase）（CYP11B2）合成^[2]。

參考文獻[編輯]

^ Human Metabolome Database: Showing metabocard for 11b-Hydroxyprogesterone (HMDB04031). hmdb.ca. [2016-12-16]. （原始內容存檔於2016-12-21）.
^ ^2.0 ^2.1 Strushkevich N, Gilep AA, Shen L, Arrowsmith CH, Edwards AM, Usanov SA, Park HW. Structural insights into aldosterone synthase substrate specificity and targeted inhibition. Molecular Endocrinology. February 2013, 27 (2): 315–24. PMC 5417327 . PMID 23322723. doi:10.1210/me.2012-1287.
^ van Rooyen D, Gent R, Barnard L, Swart AC. The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway. The Journal of Steroid Biochemistry and Molecular Biology. April 2018, 178: 203–212. PMID 29277707. doi:10.1016/j.jsbmb.2017.12.014.