纖溶酶

Plasminogen; 纖溶酶原
	PDB rendering based on 4dur.
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4DCB, 4DUR, 4DUU, 5HPG
標識
代號	PLG; DKFZp779M0222
擴展標識	遺傳學：173350 鼠基因：97620 同源基因：55452 ChEMBL: 1801 GeneCards: PLG Gene
EC編號	3.4.21.7
基因本體論描述
分子功能	· serine-type endopeptidase activity; · protein binding; · serine-type peptidase activity; · protein domain specific binding; · apolipoprotein binding;
細胞成分	· extracellular region; · extracellular space; · plasma membrane; · cell surface; · platelet alpha granule lumen; · extrinsic component of external side of plasma membrane; · extracellular vesicular exosome; · blood microparticle;
生物過程	· platelet degranulation; · blood coagulation; · negative regulation of cell proliferation; · negative regulation of cell-substrate adhesion; · extracellular matrix disassembly; · platelet activation; · extracellular matrix organization; · tissue regeneration; · fibrinolysis; · cellular protein metabolic process; · myoblast differentiation; · muscle cell cellular homeostasis; · tissue remodeling; · proteolysis involved in cellular protein catabolic process; · negative regulation of fibrinolysis; · positive regulation of fibrinolysis; · trophoblast giant cell differentiation; · labyrinthine layer blood vessel development; · mononuclear cell migration; · negative regulation of cell-cell adhesion mediated by cadherin;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
	閱; 論; 編;

纖溶酶（英語：Plasmin，EC 3.4.21.7），或譯為血漿酶、胞漿素。是血漿中的一種重要酶用以降解許多血漿蛋白，包括纖維蛋白凝塊。纖維蛋白的降解被稱為纖溶作用（英語：fibrinolysis）。在人類中，纖溶酶是由PLG 基因轉譯而成^[1]

功能[編輯]

纖溶酶與胰蛋白酶同屬一種絲氨酸蛋白酶，可以降解血栓。除了纖溶作用之外，纖溶酶也可透過多種方式降解其他蛋白質，例如活化膠原蛋白酶（英語：collagenase），或是某些補體調控物質。纖溶酶也能促使濾泡壁弱化，進而促進排卵。纖溶酶能夠降解纖維蛋白、纖連蛋白、thrombospondin（英語：thrombospondin）、層蛋白，以及von Willebrand因子（英語：von Willebrand factor）。

病理學[編輯]

缺乏纖溶酶會造成血栓無法及時溶解，進而導致血栓形成。另外，缺乏纖溶酶原的大鼠也會有肝臟修復障礙^[2]、傷口癒合障礙，及生殖功能異常等問題^{[來源請求]}。

人類有種罕見疾病稱為第一型纖溶酶原缺損症（英語：plasminogen deficiency type I）（OMIM 217090），即是因PLG基因變異，患者常會發生木樣結膜炎（英語：ligneous conjunctivitis）。

交互作用[編輯]

纖溶酶能與Thrombospondin 1（英語：Thrombospondin 1）^[3]^[4]、Alpha 2-antiplasmin（英語：Alpha 2-antiplasmin）^[5]^[6]，和IGFBP3（英語：IGFBP3）^[7]進行交互作用。

參考文獻[編輯]

^ Entrez Gene: plasminogen. （原始內容存檔於2019-09-13）.
^ Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America). December 21, 1999, 96 (26): 15143–8 [2016-03-04]. Bibcode:1999PNAS...9615143B. PMC 24787 . PMID 10611352. doi:10.1073/pnas.96.26.15143. （原始內容存檔於2014-02-28）.
^ Silverstein RL, Leung LL, Harpel PC, Nachman RL. Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J. Clin. Invest. November 1984, 74 (5): 1625–33. PMC 425339 . PMID 6438154. doi:10.1172/JCI111578.
^ DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA. Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen. Blood. March 1989, 73 (4): 976–82. PMID 2522013.
^ Wiman B, Collen D. On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin. J. Biol. Chem. September 1979, 254 (18): 9291–7. PMID 158022.
^ Shieh BH, Travis J. The reactive site of human alpha 2-antiplasmin. J. Biol. Chem. May 1987, 262 (13): 6055–9. PMID 2437112.
^ Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR. Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3. Am. J. Physiol. August 1998, 275 (2 Pt 1): E321–31. PMID 9688635.

延伸閱讀[編輯]

Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA. Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice. Proc. Natl. Acad. Sci. U.S.A. July 2005, 102 (29): 10182–7. Bibcode:2005PNAS..10210182S. PMC 1177369 . PMID 16006527. doi:10.1073/pnas.0501691102.
Anglés-Cano E, Rojas G. Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site. Biol. Chem. 2002, 383 (1): 93–9. PMID 11928826. doi:10.1515/BC.2002.009.
Ranson M, Andronicos NM. Plasminogen binding and cancer: promises and pitfalls. Front. Biosci. 2003, 8: s294–304. PMID 12700073. doi:10.2741/1044.

外部連結[編輯]

The MEROPS online database for peptidases and their inhibitors: S01.233 （頁面存檔備份，存於互聯網檔案館）
醫學主題詞表（MeSH）：Plasmin

纖溶酶引用了美國國家醫學圖書館提供的資料，這些資料屬於公共領域。

Template:Beta globulins Template:Coagulation

[entrez-1] Entrez Gene: plasminogen. （原始內容存檔於2019-09-13）.

[2] Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America). December 21, 1999, 96 (26): 15143–8 [2016-03-04]. Bibcode:1999PNAS...9615143B. PMC 24787 . PMID 10611352. doi:10.1073/pnas.96.26.15143. （原始內容存檔於2014-02-28）.

[pmid6438154-3] Silverstein RL, Leung LL, Harpel PC, Nachman RL. Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J. Clin. Invest. November 1984, 74 (5): 1625–33. PMC 425339 . PMID 6438154. doi:10.1172/JCI111578.

[pmid2522013-4] DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA. Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen. Blood. March 1989, 73 (4): 976–82. PMID 2522013.

[pmid158022-5] Wiman B, Collen D. On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin. J. Biol. Chem. September 1979, 254 (18): 9291–7. PMID 158022.

[pmid2437112-6] Shieh BH, Travis J. The reactive site of human alpha 2-antiplasmin. J. Biol. Chem. May 1987, 262 (13): 6055–9. PMID 2437112.

[pmid9688635-7] Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR. Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3. Am. J. Physiol. August 1998, 275 (2 Pt 1): E321–31. PMID 9688635.

[1]

[2]

[3]

[4]

[5]

[6]

[7]