血管紧张素转化酶2

血管紧张素转化酶2
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3SCL、1R42、1R4L、2AJF、3D0G、3D0H、3D0I、3KBH、3SCI、3SCJ、3SCK
識別號
别名	ACE2；, ACEH, angiotensin I converting enzyme 2, ACE 2
外部ID	OMIM：300335 MGI：1917258 HomoloGene：41448 GeneCards：ACE2
基因位置（人类）
染色体	X染色體
终止	15,602,148 bp
基因位置（小鼠）
染色体	小鼠X染色体
终止	162,971,416 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• peptidyl-dipeptidase activity; • virus receptor activity; • 鋅離子結合; • endopeptidase activity; • 金屬離子結合; • 肽酶活性; • 血浆蛋白结合; • carboxypeptidase activity; • 水解酶活性; • metallopeptidase activity; • metallocarboxypeptidase activity; • exopeptidase activity;
細胞組分	• 細胞質; • integral component of membrane; • 膜; • 细胞膜; • 細胞外區域; • cell surface; • 脂筏模型; • 外排體; • 細胞外空間; • brush border membrane;
生物學過程	• regulation of cardiac conduction; • angiotensin-mediated drinking behavior; • 蛋白酶解; • regulation of cytokine production; • positive regulation of reactive oxygen species metabolic process; • regulation of vasoconstriction; • regulation of cell population proliferation; • positive regulation of cardiac muscle contraction; • regulation of inflammatory response; • positive regulation of gap junction assembly; • 病毒进入; • viral process; • regulation of systemic arterial blood pressure by renin-angiotensin; • tryptophan transport; • blood vessel diameter maintenance; • angiotensin maturation; • receptor-mediated virion attachment to host cell; • positive regulation of amino acid transport;
	Sources:Amigo / QuickGO
直系同源
	59272
	70008
	ENSG00000130234
	ENSMUSG00000015405
	Q9BYF1
	Q8R0I0
	NM_021804; NM_001371415
	NM_001130513; NM_027286
	NP_068576; NP_001358344
	NP_001123985; NP_081562
	維基數據
檢視/編輯人類	檢視/編輯小鼠

血管紧张素转化酶2（英語：Angiotensin-converting enzyme 2，ACE2）是一種附著在肺，動脈，心臟，腎臟和腸道中細胞表面（細胞膜）上的酶。是一种能催化血管紧张素I转化为血管紧张素-（1-9）^[5]或血管紧张素II转化为血管紧张素-（1-7）^[6]的外肽酶。此外，ACE2还是SARS 冠状病毒（SARS-CoV）、嚴重急性呼吸系統綜合症冠狀病毒2型（SARS-CoV-2）和人類冠狀病毒NL63的受体^[7]。 ACE2对ACE抑制剂药物不敏感 ^[8]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000130234 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000015405 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 2000, 87 (5): E1–9. PMID 10969042.
^ Keidar S, Kaplan M, Gamliel-Lazarovich A. ACE2 of the heart: From angiotensin I to angiotensin (1-7). Cardiovasc Res. 2007, 73 (3): 463–9. PMID 17049503.
^ Weiss SR, Navas-Martin S. Angiotensin-converting enzyme 2--a new cardiac regulator. Microbiol Mol Biol Rev. 2005, 69 (4): 635–64. PMID 16339739.
^ Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021.

延伸閲讀

Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021.
Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends in Pharmacological Sciences. Jun 2004, 25 (6): 291–4. PMID 15165741. doi:10.1016/j.tips.2004.04.001.
Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. Experimental Physiology. May 2005, 90 (3): 299–305. PMID 15640278. doi:10.1113/expphysiol.2004.028522.
Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. American Journal of Physiology. Heart and Circulatory Physiology. Dec 2005, 289 (6): H2281–90. PMID 16055515. doi:10.1152/ajpheart.00618.2005.
Jia HP, Look DC, Hickey M, Shi L, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray PB. Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. Advances in Experimental Medicine and Biology. 2006, 581: 479–84. ISBN 978-0-387-26202-4. PMID 17037581. doi:10.1007/978-0-387-33012-9_85.
Lazartigues E, Feng Y, Lavoie JL. The two fACEs of the tissue renin–angiotensin systems: implication in cardiovascular diseases. Current Pharmaceutical Design. 2007, 13 (12): 1231–45. PMID 17504232. doi:10.2174/138161207780618911.
Raizada MK, Ferreira AJ. ACE2: a new target for cardiovascular disease therapeutics. Journal of Cardiovascular Pharmacology. Aug 2007, 50 (2): 112–9. PMID 17703127. doi:10.1097/FJC.0b013e3180986219.
Dean RG, Burrell LM. ACE2 and diabetic complications. Current Pharmaceutical Design. 2007, 13 (26): 2730–5. PMID 17897017. doi:10.2174/138161207781662876.
Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33238–43. PMID 10924499. doi:10.1074/jbc.M002615200.
Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circulation Research. Sep 2000, 87 (5): E1–9. PMID 10969042. doi:10.1161/01.res.87.5.e1.
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. The Journal of Biological Chemistry. Apr 2002, 277 (17): 14838–43. PMID 11815627. doi:10.1074/jbc.M200581200.
Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. Jun 2002, 417 (6891): 822–8. PMID 12075344. doi:10.1038/nature00786.
Harmer D, Gilbert M, Borman R, Clark KL. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Letters. Dec 2002, 532 (1-2): 107–10. PMID 12459472. doi:10.1016/S0014-5793(02)03640-2.
Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. Journal of Molecular and Cellular Cardiology. Sep 2003, 35 (9): 1043–53. PMID 12967627. doi:10.1016/S0022-2828(03)00177-9.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Research. Oct 2003, 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. Nov 2003, 426 (6965): 450–4. PMID 14647384. doi:10.1038/nature02145.
Wong SK, Li W, Moore MJ, Choe H, Farzan M. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. The Journal of Biological Chemistry. Jan 2004, 279 (5): 3197–201. PMID 14670965. doi:10.1074/jbc.C300520200.
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. The Journal of Biological Chemistry. Apr 2004, 279 (17): 17996–8007. PMID 14754895. doi:10.1074/jbc.M311191200.

参见

外部連結

Human ACE2 genome location and ACE2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000130234 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000015405 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10969042-5] Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 2000, 87 (5): E1–9. PMID 10969042.

[pmid17049503-6] Keidar S, Kaplan M, Gamliel-Lazarovich A. ACE2 of the heart: From angiotensin I to angiotensin (1-7). Cardiovasc Res. 2007, 73 (3): 463–9. PMID 17049503.

[pmid16339739-7] Weiss SR, Navas-Martin S. Angiotensin-converting enzyme 2--a new cardiac regulator. Microbiol Mol Biol Rev. 2005, 69 (4): 635–64. PMID 16339739.

[8] Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021.

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