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视黄酸受体α

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RARA
Protein RARA PDB 1dkf.png
已知的结构
PDBOrtholog search: PDBe RCSB
识别号
别名RARA;NR1B1、​RAR、​retinoic acid receptor alpha
外部IDMGI97856 HomoloGene20262 GeneCardsRARA
为以下药物的标靶
阿达帕林、​alitretinoin、​tamibarotene、​tazarotene、​维A酸[1]
RNA表达模式
PBB GE RARA 203750 s at fs.png

PBB GE RARA 211605 s at fs.png

PBB GE RARA 203749 s at fs.png
更多参考(基因)表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

XM_011525096、NM_000964、NM_001024809、NM_001033603、NM_001145301、NM_001145302、XM_005257552、XM_005257553、XM_005257554、XM_011525095、XM_017024920

NM_001176528、NM_001177302、NM_001177303、NM_009024、XM_006532592、XM_006532593、XM_006532596、XM_006532597、XM_017314353、NM_001361954

蛋白序列

NP_000955、NP_001019980、NP_001138773、NP_001138774、XP_005257609、XP_005257610、XP_005257611、XP_011523397、XP_011523398、XP_016880409
NP_000955.1、NP_001138773.1、XP_005257610.1、XP_005257611.1、XP_011523397.1

NP_001169999、NP_001170773、NP_001170774、NP_033050、XP_006532655、XP_006532656、XP_006532659、XP_006532660、XP_017169842、NP_001348883

基因位置​(UCSC)Chr 17: 40.31 – 40.36 Mbn/a
PubMed​查找[2][3]
维基数据
检视/编辑 人类检视/编辑 小鼠

视黄酸受体α英语:Retinoic acid receptor alphaRAR-α),也称为NR1B1(核受体第一亚族B组成员1,nuclear receptor subfamily 1, group B, member 1)是一个核受体,在人类基因组中由 RARA 基因编码。[4][5]

相互作用[编辑]

视黄酸受体α可以与下列蛋白质发生进行交互作用

参考文献[编辑]

  1. ^ 对Retinoic acid receptor alpha起作用的药物;在维基数据上查看/编辑参考. 
  2. ^ Human PubMed Reference:. 
  3. ^ Mouse PubMed Reference:. 
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  7. ^ 7.0 7.1 McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell. June 2001, 105 (7): 877–89. PMID 11439184. doi:10.1016/S0092-8674(01)00401-9. 
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  17. ^ Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN. Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity. Biochemistry. February 2003, 42 (4): 971–9. PMID 12549917. doi:10.1021/bi020497k. 
  18. ^ L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG. RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol. Cell. Biol. November 1996, 16 (11): 6029–36. PMC 231605. PMID 8887632. 
  19. ^ Seol W, Choi HS, Moore DD. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. May 1996, 272 (5266): 1336–9. PMID 8650544. doi:10.1126/science.272.5266.1336. 
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