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STAT1

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维基百科,自由的百科全书
STAT1
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名STAT1;, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部IDOMIM600555 MGI103063 HomoloGene21428 GeneCardsSTAT1
相关疾病
慢性黏膜皮肤念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置(人类
2号染色体
染色体2号染色体[2]
2号染色体
STAT1的基因位置
STAT1的基因位置
基因座2q32.2起始190,908,460 bp[2]
终止191,020,960 bp[2]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_007315
​NM_139266

NM_001205313
​NM_001205314
​NM_009283
​NM_001357627

蛋白序列

NP_009330
​NP_644671

无数据

基因位置​(UCSC)Chr 2: 190.91 – 191.02 MbChr 1: 52.16 – 52.2 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

STAT1转录因子信号转导及转录激活蛋白(STAT蛋白)家族的一员。

STAT1涉及I型II型III型干扰素激活基因的正调控。在干扰素-γ刺激下,STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS(Interferon-Gamma-Activated Sequence,干扰素γ激活序列)启动子上;而在干扰素-α或干扰素-β刺激下,STAT1会与STAT2组成异二聚体结合到ISREInterferon-Stimulated Response Element,干扰素激活反应元件)启动子上[6]。在这两种情况下,STAT二聚体与启动子的结合都会导致ISGInterferon-Stimulated Genes,干扰素激活基因)的表达。

STAT1可由二烯丙基二硫诱导表达[7]

相互作用

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STAT1能与下列蛋白质发生相互作用

参考文献

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  1. ^ 與STAT1相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Michael G. Katze; Yupeng He & Michael Gale; et al. Viruses and interferon: a fight for supremacy. Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 
  7. ^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871. 
  8. ^ Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. (ENGLAND). March 1997, 16 (6): 1291–304. ISSN 0261-4189. PMC 1169727可免费查阅. PMID 9135145. doi:10.1093/emboj/16.6.1291. 
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  22. ^ Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895可免费查阅. PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000. 
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