胃腸道基質腫瘤

维基百科,自由的百科全书
跳转至: 导航搜索
胃腸道基質腫瘤
Gastric GIST (1).jpg
部胃腸道基質腫瘤之組織病理影像(以蘇木精伊紅著色顯示)
分类和外部资源
醫學專科 肿瘤学
ICD-10 D37
ICD-O英语International Classification of Diseases for Oncology M8936/0 - M8936/3
OMIM 606764
DiseasesDB 33849
MeSH D046152
GIST內視鏡影像位於的底部,見於後屈(retroflexion)部
同樣的內視鏡前端GIST影像,顯示出腫瘤的高度凝塊


胃腸道基質腫瘤Gastrointestinal stromal tumor,簡稱GISTs),為最常見的消化道間質腫瘤。GIST源自於卡氏間質細胞平滑肌節律細胞[1]。本疾病一般是因為KIT基因英语KIT (gene)突變所致(85%)[1],少數則由PDGFRA英语PDGFRA(10%)[1]、BRAF激酶基因突變引起[1]。95%的GIST在c-Kit(CD117)免疫染色下會呈陽性[1][2]。腫瘤最常見於胃部(66%),但源發於胃部的GIST一般相較於源發於消化道以外的GIST,惡性度會較低[2]。GIST的影響範圍不限定於腸道,而可以遍及食道小腸大腸直腸;而隨着GIST在消化道的不同部位發生,病者亦會出現不同的病徵[3]


參考文獻[编辑]

  1. ^ 1.0 1.1 1.2 1.3 1.4 Demetri, G., chapter author; DeVita, L; Lawrence, TS; Rosenberg, SA., editors. Chapter 87. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology 9th. 2011. ISBN 978-1-4511-0545-2. 
  2. ^ 2.0 2.1 Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006, 130 (10): 1466–78. PMID 17090188. doi:10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2. 
  3. ^ 朱建華,(2007年),〈腸話短說:認識胃腸道基質腫瘤〉,《都市日報》2007年11月23日號,P.34 健康。


外部連結[编辑]

醫學研究連結[编辑]

病患導向之網站[编辑]

  • GIST Support International, An international organization for the support of GIST patients, families, and friends. Includes detailed information from some of the foremost experts on GIST, links to research, treatment options, GIST registry, adult and pediatric listservs, and affiliated GSI-Wiki.
  • Life Raft Group International GIST Advocacy Organization. Provides support to patients & families, through information, education, and innovative research.
  • GIST Info Patient links, includes information on new clinical trials and research
  • American Cancer Society Patient Guide to GIST tumors.
  • GIST 胃腸不可Blog