黄体生成素β亚基

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Luteinizing hormone beta polypeptide
黄体生成素β多肽
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 LHB; CGB4; LSH-B; hLHB
扩展标识 遗传学152780 鼠基因96782 同源基因81806 GeneCards: LHB Gene
RNA表达模式
PBB GE LHB 214471 x at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 3972 16866
Ensembl ENSG00000104826 ENSMUSG00000038194
UniProt P01229 G3X9G6
mRNA序列 NM_000894 NM_008497
蛋白序列 NP_000885 NP_032523
基因位置 Chr 19:
49.52 – 49.52 Mb
Chr 7:
45.42 – 45.42 Mb
PubMed查询 [1] [2]

黄体生成素β亚基英语Luteinizing hormone subunit beta 或 lutropin subunit beta )是一种由人类基因LHB 编码的蛋白质[1][2]

基因[编辑]

该基因位于19号染色体q13.3,编码黄体生成素的β亚基[2]。而在马科动物中,黄体生成素的β亚基和绒毛膜促性腺激素的β亚基是由一个基因编码的[3]

功能[编辑]

临床意义[编辑]

参考文献[编辑]

  1. ^ Sairam MR, Li CH. Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. Biochim Biophys Acta. Feb 1976, 412 (1): 70–81. PMID 1191677. 
  2. ^ 2.0 2.1 Entrez Gene: LHB luteinizing hormone beta polypeptide. 
  3. ^ Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH. A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin. Mol. Endocrinol. June 1992, 6 (6): 951–9. doi:10.1210/me.6.6.951. PMID 1379674. 


延伸阅读[编辑]

  • Keutmann HT, Hua QX, Weiss MA. Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy. Mol. Endocrinol. 1992, 6 (6): 904–13. doi:10.1210/me.6.6.904. PMID 1495492. 
  • Weiss J, Axelrod L, Whitcomb RW; 等. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N. Engl. J. Med. 1992, 326 (3): 179–83. doi:10.1056/NEJM199201163260306. PMID 1727547. 
  • Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. Eur. J. Biochem. 1991, 195 (1): 257–68. doi:10.1111/j.1432-1033.1991.tb15702.x. PMID 1991473. 
  • Jameson JL, Lindell CM, Habener JF. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA. 1986, 5 (3): 227–34. doi:10.1089/dna.1986.5.227. PMID 2424697. 
  • Keutmann HT, Charlesworth MC, Mason KA; 等. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. doi:10.1073/pnas.84.7.2038. PMC 304579. PMID 3470775. 
  • Shome B, Parlow AF. The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH). J. Clin. Endocrinol. Metab. 1973, 36 (3): 618–21. doi:10.1210/jcem-36-3-618. PMID 4685398. 
  • Closset J, Hennen G, Lequin RM. Human luteinizing hormone. The amino acid sequence of the subunit. FEBS Lett. 1973, 29 (2): 97–100. doi:10.1016/0014-5793(73)80534-4. PMID 4719207. 
  • Talmadge K, Vamvakopoulos NC, Fiddes JC. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. Nature. 1984, 307 (5946): 37–40. doi:10.1038/307037a0. PMID 6690982. 
  • Beitins IZ, Axelrod L, Ostrea T; 等. Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone. J. Clin. Endocrinol. Metab. 1981, 52 (6): 1143–9. doi:10.1210/jcem-52-6-1143. PMID 6785294. 
  • Berger P, Kranewitter W, Madersbacher S; 等. Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. FEBS Lett. 1994, 343 (3): 229–33. doi:10.1016/0014-5793(94)80561-X. PMID 7513655. 
  • Keutmann HT, Rubin DA. A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology. 1993, 132 (3): 1305–12. doi:10.1210/en.132.3.1305. PMID 7679977. 
  • Herrlich A, Kühn B, Grosse R; 等. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J. Biol. Chem. 1996, 271 (28): 16764–72. doi:10.1074/jbc.271.28.16764. PMID 8663226. 
  • Muyan M, Furuhashi M, Sugahara T, Boime I. The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers. Mol. Endocrinol. 1997, 10 (12): 1678–87. doi:10.1210/me.10.12.1678. PMID 8961276. 
  • Roy AC, Liao WX, Chen Y; 等. Identification of seven novel mutations in LH beta-subunit gene by SSCP. Mol. Cell. Biochem. 1997, 165 (2): 151–3. PMID 8979264. 
  • Liao WX, Roy AC, Chan C; 等. A new molecular variant of luteinizing hormone associated with female infertility. Fertil. Steril. 1998, 69 (1): 102–6. doi:10.1016/S0015-0282(97)00445-7. PMID 9457942. 
  • O'Connor JF, Kovalevskaya G, Birken S; 等. The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay. Hum. Reprod. 1998, 13 (4): 826–35. doi:10.1093/humrep/13.4.826. PMID 9619532. 
  • Takahashi K, Kurioka H, Ozaki T; 等. Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Hum. Reprod. 1999, 13 (12): 3338–44. doi:10.1093/humrep/13.12.3338. PMID 9886510. 
  • Elter K, Erel CT, Cine N; 等. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil. Steril. 1999, 71 (3): 425–30. doi:10.1016/S0015-0282(98)00491-9. PMID 10065776. 
  • Jiang M, Pakarinen P, Zhang FP; 等. A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum. Mol. Genet. 1999, 8 (11): 2037–46. doi:10.1093/hmg/8.11.2037. PMID 10484773.