降鈣素
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| Calcitonin/calcitonin-related polypeptide, alpha | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; MGC126648 | ||||||||||||
| 扩展标识 | 遗传学：114130 鼠基因：2151253 同源基因：1319 GeneCards: CALCA Gene | ||||||||||||
| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 796 | 12310 | |||||||||||
| Ensembl | ENSG00000110680 | ENSMUSG00000030669 | |||||||||||
| UniProt | P01258 | Q99JA0 | |||||||||||
| mRNA序列 | NM_001033952 | NM_001033954 | |||||||||||
| 蛋白序列 | NP_001029124 | NP_001029126 | |||||||||||
| 基因位置 |
Chr 11: 14.94 – 14.95 Mb |
Chr 7: 114.42 – 114.43 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
降鈣素（英语：Calcitonin，又譯为抑鈣激素）是一種含有32個胺基酸的直線型多肽類激素，在人體裡是由甲狀腺的濾泡旁細胞（parafollicular cells，又稱C細胞）製造。在魚類、爬蟲類、鳥類、哺乳類身上都有發現這種激素。主要功能是降低血鈣。但降鈣素對於調節人體血液中鈣離子(Ca2+)的恆定通常並沒有很顯著的重要性。[2]
主要作用[编辑]
降鈣素影響了鈣離子和磷酸鹽的代謝過程，其功能多半是拮抗副甲狀腺素的作用。[3]
降鈣素主要透過下列四種方式降低血鈣濃度：
- 抑制小腸對於鈣離子的吸收。[4]
- 抑制蝕骨細胞（Osteoclast），減少骨骼中的鈣離子流失到血液中。[5]
- 抑制腎小管對磷酸根的再吸收作用。[6]
- 抑制腎小管對鈣離子的再吸收作用，增加鈣離子自尿液流失。[6]
分泌[编辑]
刺激降鈣素分泌的因素：
- 血漿中鈣離子濃度過高[7]
參考資料[编辑]
- ^ PDB 2glhAndreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A. Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix. J. Biol. Chem. August 2006, 281 (34): 24193–203. PMID 16766525. doi:10.1074/jbc.M603528200.
- ^ Costoff A. Sect. 5, Ch. 6: Biological Actions of CT. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-07-05）.
- ^ Boron WF, Boulpaep EL. Endocrine system chapter. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. 2004. ISBN 1-4160-2328-3.
- ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on the Small Intestine. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-10-06）.
- ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on Bone. Medical College of Georgia. [2008-08-07]. （原始内容存档于2008-06-22）.
- ^ 6.0 6.1 Carney SL. Calcitonin and human renal calcium and electrolyte transport. Miner Electrolyte Metab. 1997, 23 (1): 43–7. PMID 9058369.
- ^ Costanzo, Linda S. BRS Physiology. Lippincott, Williams, & Wilkins. 2007: 263. ISBN 978-0781773119.
- ^ Erdogan MF, Gursoy A, Kulaksizoglu M. Long-term effects of elevated gastrin levels on calcitonin secretion. J Endocrinol Invest. October 2006, 29 (9): 771–775. PMID 17114906. （原始内容存档于2016-05-15）.
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