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胰岛素样生长因子1

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IGF1
Protein IGF1 PDB 1bqt.png
已知的結構
PDB Ortholog search: PDBe RCSB
識別號
别名 IGF1;IGF-I、​IGF1A、​IGFI、​MGF、​insulin like growth factor 1
外部ID OMIM147440 HomoloGene515 GeneCardsIGF1
RNA表达模式
PBB GE IGF1 209540 at.png

PBB GE IGF1 209541 at.png

PBB GE IGF1 209542 x at.png
更多參考(基因)表达數據
直系同源
物種 人類 小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_000618、NM_001111283、NM_001111284、NM_001111285、XM_017019259、XM_017019260、XM_017019261、XM_017019262、XM_017019263

NM_001082477、NM_001082478、NM_001082479、NM_178866、XM_006241191、XM_006241192、XM_006241193、XM_006241194

蛋白序列

NP_000609、NP_001104753、NP_001104754、NP_001104755、XP_016874748、XP_016874749、XP_016874750、XP_016874751、XP_016874752

NP_001075946、NP_001075947、NP_001075948、NP_849197、XP_006241253、XP_006241254、XP_006241255、XP_006241256

基因位置​(UCSC) Chr 12: 102.4 – 102.48 Mb n/a
PubMed​查找 [1] [2]
維基數據
檢視/編輯 人類 檢視/編輯 小鼠

胰岛素样生长因子1英语:Insulin-like growth factor 1IGF-1)也被称为生长调节素C(somatomedin C),是一个由人类基因 IGF1 编码的蛋白质[3][4]。在1970年代,IGF-1也曾经被称为“酸硫化英语sulfation因子”[5],並認為其作用为“不受抑制的胰岛样活力”(nonsuppressible insulin-like activity,NSILA)。

IGF-1是一个在三级结构上与胰岛素类似的激素,在儿童成长发育中有重要作用,并持续在成人的合成代谢中起作用。一种人工合成的IGF-1类似物,美卡舍明英语mecasermin,用于治疗发育停滞[6]

IGF-1蛋白由一个肽链构成,包括70个氨基酸残基和三个分子内二硫键,分子量为7,649道尔顿[7]

参考文献[编辑]

  1. ^ Human PubMed Reference:. 
  2. ^ Mouse PubMed Reference:. 
  3. ^ Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288. 
  4. ^ Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0. 
  5. ^ Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201. 
  6. ^ Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004. 
  7. ^ Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300. 

延伸阅读[编辑]

  • Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis?. News Physiol. Sci. 2002, 17: 82–5. PMID 11909998. 
  • Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E. Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity. Ann. Endocrinol. (Paris). 2002, 63 (2 Pt 1): 140–4. PMID 11994678. 
  • Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion. Reviews in endocrine & metabolic disorders. 2003, 3 (4): 357–61. PMID 12424437. doi:10.1023/A:1020957809082. 
  • Dantzer B, Swanson EM. Mediation of vertebrate life histories via insulin-like growth factor-1. Biological Reviews. 2012, 87 (2): 414–429. PMID 21981025. doi:10.1111/j.1469-185X.2011.00204.x. 
  • Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J. IGF-I: from diagnostic to triple-helix gene therapy of solid tumors. Acta Biochim. Pol. 2004, 49 (4): 979–90. PMID 12545204. 
  • Winn N, Paul A, Musaró A, Rosenthal N. Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harb. Symp. Quant. Biol. 2003, 67: 507–18. PMID 12858577. doi:10.1101/sqb.2002.67.507. 
  • Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 2005, 24 (3): 435–44. PMID 14604834. doi:10.1161/01.ATV.0000105902.89459.09. 
  • Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I. Role of insulin-like growth factor I signaling in neurodegenerative diseases. J. Mol. Med. 2004, 82 (3): 156–62. PMID 14647921. doi:10.1007/s00109-003-0499-7. 
  • Rabinovsky ED. The multifunctional role of IGF-1 in peripheral nerve regeneration. Neurol. Res. 2004, 26 (2): 204–10. PMID 15072640. doi:10.1179/016164104225013851. 
  • Rincon M, Muzumdar R, Atzmon G, Barzilai N. The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech. Ageing Dev. 2005, 125 (6): 397–403. PMID 15272501. doi:10.1016/j.mad.2004.03.006. 
  • Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F. Insulin-like growth factor-1 as a vascular protective factor. Circulation. 2005, 110 (15): 2260–5. PMID 15477425. doi:10.1161/01.CIR.0000144309.87183.FB. 
  • Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int. Rev. Cytol. International Review of Cytology. 2005, 243: 215–85. ISBN 9780123646477. PMID 15797461. doi:10.1016/S0074-7696(05)43004-1. 
  • Sandhu MS. Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocrine development. Endocrine Development. 2005, 9: 44–54. ISBN 3-8055-7926-8. PMID 15879687. doi:10.1159/000085755. 
  • Ye P, D'Ercole AJ. Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system. J. Neurosci. Res. 2006, 83 (1): 1–6. PMID 16294334. doi:10.1002/jnr.20688. 
  • Gómez JM. The role of insulin-like growth factor I components in the regulation of vitamin D. Current pharmaceutical biotechnology. 2006, 7 (2): 125–32. PMID 16724947. doi:10.2174/138920106776597621. 
  • Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S. Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). J. Endocrinol. Invest. 2006, 29 (8): 732–7. PMID 17033263. doi:10.1007/bf03344184. 
  • Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. Med. Hypotheses. 2007, 69 (2): 302–6. PMID 17289286. doi:10.1016/j.mehy.2006.11.045. 
  • Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience. 2007, 145 (3): 795–811. PMID 17320297. doi:10.1016/j.neuroscience.2007.01.021. 
  • Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. Am J Psychiatry. October 2007, 164 (10): 1557–60. PMID 17898347. doi:10.1176/appi.ajp.2007.07020233. 

外部链接[编辑]