非特異性間質性肺炎
非特異性間質性肺炎（Non-specific interstitial pneumonia，簡稱NSIP）屬於一種特發性間質性肺炎。
症狀
[编辑]病因
[编辑]目前認為屬於一種自體免疫有關，可能為未分化型結締組織疾病的併發症[2]。
分類
[编辑]NSIP可依病理切片分為細胞性及纖維性兩種，兩種以預後不同。細胞性的鏡檢會顯示慢性發炎但纖維化較少的情形；纖維性則會顯示間質性纖維化，且發炎狀態不一。在其他種類的特發性肺炎一般有一個明顯的點狀纖維化區域，但在NSIP中沒有這種情形，一般為一整片的纖維化[3]。
預後
[编辑]纖維性NSIP的五年存活率約於 86% 至 92%之間，細胞性則為 100% 。大體來說NSIP的預後較尋常性間質性肺炎（UIP）為佳[4]。
參考文獻
[编辑]- ^ Cottin, Vincent, et al. "Nonspecific interstitial pneumonia: individualization of a clinicopathologic entity in a series of 12 patients." American journal of respiratory and critical care medicine 158.4 (1998): 1286-1293.
- ^ Kinder, Brent W., et al. "Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?." American journal of respiratory and critical care medicine 176.7 (2007): 691-697.
- ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project." American journal of respiratory and critical care medicine 177.12 (2008): 1338-1347.
- ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia." The American journal of surgical pathology 24.1 (2000): 19-33.