NEUROD1

NEUROD1
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2QL2
识别号
别名	NEUROD1；, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D
外部ID	OMIM：601724 MGI：1339708 HomoloGene：1871 GeneCards：NEUROD1
基因位置（人类）
染色体	2号染色体
终止	181,680,827 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	79,287,095 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• sequence-specific DNA binding; • 转录共激活因子活性; • DNA结合; • protein dimerization activity; • DNA结合转录因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • chromatin binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • E-box binding; • 血浆蛋白结合; • protein heterodimerization activity; • double-stranded DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
细胞组分	• 细胞质; • 胞内; • 核质; • RNA polymerase II transcription regulator complex; • 细胞核;
生物学过程	• positive regulation of transcription regulatory region DNA binding; • regulation of neuron differentiation; • 神经发生; • 细胞分化; • cell fate commitment; • regulation of transcription, DNA-templated; • pancreatic PP cell fate commitment; • glucose homeostasis; • regulation of insulin secretion; • enteroendocrine cell differentiation; • dentate gyrus development; • signal transduction involved in regulation of gene expression; • neuron development; • insulin secretion; • positive regulation of DNA-binding transcription factor activity; • response to glucose; • transcription by RNA polymerase II; • embryonic organ morphogenesis; • cerebellum development; • transcription, DNA-templated; • 神经系统的发育; • positive regulation of transcription, DNA-templated; • multicellular organism development; • hindbrain development; • nucleocytoplasmic transport; • positive regulation of neuron differentiation; • positive regulation of cell differentiation; • nitric oxide mediated signal transduction; • positive regulation of apoptotic process; • regulation of intestinal epithelial structure maintenance; • 内耳的发生; • camera-type eye development; • pancreatic A cell fate commitment; • amacrine cell differentiation; • negative regulation of type B pancreatic cell apoptotic process; • cellular response to glucose stimulus; • anterior/posterior pattern specification; • endocrine pancreas development; • positive regulation of transcription by RNA polymerase II; • negative regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
直系同源
	4760
	18012
	ENSG00000162992
	ENSMUSG00000034701
	Q13562
	Q60867
	NM_002500
	NM_010894
	NP_002491
	NP_035024
	维基数据
查看/编辑人类	查看/编辑小鼠

NEUROD1，（小鼠的同源蛋白质记为NeuroD1）在人体内是NeuroD蛋白家族下的一个转录因子，由NEUROD1基因编码。NEUROD1在神经系统发育中扮演重要角色，于发育中参与调控多种神经系细胞的分化过程^[5]^[6]。

证据表明NEUROD1与II型糖尿病的发生关系密切^[7]。一项研究表明在小鼠大脑内过表达NEUROD1可使神经胶质细胞转分化为神经元^[8]。

蛋白质相互作用

已知NEUROD1会和周期蛋白D1^[9]、MAFA^[10]、MAP3K10^[11]发生相互作用。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Poulin, G; Turgeon, B; Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology. 1997-11, 17 (11): 6673–6682 [2021-11-10]. ISSN 0270-7306. PMC 232521 . PMID 9343431. doi:10.1128/MCB.17.11.6673. （原始内容存档于2021-11-10）（英语）.
^ NEUROD1. UniProt. [2018-02-25]. （原始内容存档于2018-02-25）.
^ NEUROD1 neuronal differentiation 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
^ Guo, Ziyuan; Zhang, Lei; Wu, Zheng; Chen, Yuchen; Wang, Fan; Chen, Gong. In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell. 2014-02, 14 (2): 188–202 [2021-11-10]. PMC 3967760 . PMID 24360883. doi:10.1016/j.stem.2013.12.001. （原始内容存档于2022-02-17）（英语）.
^ Ratineau, Christelle; Petry, Mary W.; Mutoh, Hiroyuki; Leiter, Andrew B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. The Journal of Biological Chemistry. 2002-03-15, 277 (11): 8847–8853 [2021-11-10]. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200. （原始内容存档于2021-11-10）.
^ Zhao, Li; Guo, Min; Matsuoka, Taka-Aki; Hagman, Derek K.; Parazzoli, Susan D.; Poitout, Vincent; Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 2005-03-25, 280 (12): 11887–11894 [2021-11-10]. ISSN 0021-9258. PMID 15665000. doi:10.1074/jbc.M409475200. （原始内容存档于2022-04-19）.
^ Marcora, E.; Gowan, K.; Lee, J. E. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proceedings of the National Academy of Sciences. 2003-08-05, 100 (16): 9578–9583. ISSN 0027-8424. PMC 170960 . PMID 12881483. doi:10.1073/pnas.1133382100 （英语）.

这是一篇与生物化学相关的小作品。您可以通过编辑或修订扩充其内容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Poulin, G; Turgeon, B; Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Molecular and Cellular Biology. 1997-11, 17 (11): 6673–6682 [2021-11-10]. ISSN 0270-7306. PMC 232521 . PMID 9343431. doi:10.1128/MCB.17.11.6673. （原始内容存档于2021-11-10）（英语）.

[6] NEUROD1. UniProt. [2018-02-25]. （原始内容存档于2018-02-25）.

[entrez-7] NEUROD1 neuronal differentiation 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.

[8] Guo, Ziyuan; Zhang, Lei; Wu, Zheng; Chen, Yuchen; Wang, Fan; Chen, Gong. In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell. 2014-02, 14 (2): 188–202 [2021-11-10]. PMC 3967760 . PMID 24360883. doi:10.1016/j.stem.2013.12.001. （原始内容存档于2022-02-17）（英语）.

[pmid11788592-9] Ratineau, Christelle; Petry, Mary W.; Mutoh, Hiroyuki; Leiter, Andrew B. Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. The Journal of Biological Chemistry. 2002-03-15, 277 (11): 8847–8853 [2021-11-10]. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200. （原始内容存档于2021-11-10）.

[pmid15665000-10] Zhao, Li; Guo, Min; Matsuoka, Taka-Aki; Hagman, Derek K.; Parazzoli, Susan D.; Poitout, Vincent; Stein, Roland. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 2005-03-25, 280 (12): 11887–11894 [2021-11-10]. ISSN 0021-9258. PMID 15665000. doi:10.1074/jbc.M409475200. （原始内容存档于2022-04-19）.

[pmid12881483-11] Marcora, E.; Gowan, K.; Lee, J. E. Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2. Proceedings of the National Academy of Sciences. 2003-08-05, 100 (16): 9578–9583. ISSN 0027-8424. PMC 170960 . PMID 12881483. doi:10.1073/pnas.1133382100 （英语）.

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